{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:12:42Z","timestamp":1788372762002,"version":"build-2803163510"},"reference-count":18,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["jcvtr.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Thorac Res"],"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Introduction<\/jats:italic>\n            <\/jats:bold>: Studies found that the inflammation plays a key role in the pathogenesis of paroxysmal atrial fibrillation (PAF). It is well-known that apolipoprotein-A1 (Apo-A1) demonstrates antiinflammatory and anti-oxidant properties in a healthy physiological system. In the present study, we aimed to determine whether there is any difference of Apo-A1 levels in patients with PAF and healthy subjects. <jats:bold><jats:italic>Methods:<\/jats:italic><\/jats:bold>  In this prospective cohort study, we enrolled a total of 35 PAF patients and 34 comparable healthy participants. Apo-A1 levels were measured from each subject using an immunophelometric method. All enrolled subjects were followed-up for one year during the study period. <jats:italic><jats:bold>Results<\/jats:bold><\/jats:italic>: Serum high-sensitivity C-reactive protein (hs-CRP) levels were statistically higher in PAF patients compared to healthy subjects (1.54\u00b11.99 vs. 1.06\u00b12.01, <jats:italic>P<\/jats:italic>= 0.016, respectively). Of note, patients with PAF had lower Apo-A1 levels (1.84\u00b10.74 vs. 2.55\u00b10.44, <jats:italic>P<\/jats:italic>= 0.001, respectively). There was no statistical difference between the groups in terms of apolipoprotein-B levels (1.08\u00b10.36 vs. 0.99\u00b10.38, <jats:italic>P<\/jats:italic>= 0.339, respectively). We did not find any correlation between Apo-A1 levels and PAF attacks in the study. <jats:italic><jats:bold>Conclusion<\/jats:bold><\/jats:italic>: The main finding of this study was that Apo-A1 levels were significantly lower in PAF patients compared to healthy participants. Based on our results, we considered that Apo-A1 may have a key role in the pathogenesis of PAF.<\/jats:p>","DOI":"10.34172\/jcvtr.2020.23","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T08:59:43Z","timestamp":1593680383000},"page":"140-144","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of apolipoprotein-A1 levels between paroxysmal atrial fibrillation patients and healthy subjects"],"prefix":"10.34172","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8188-5020","authenticated-orcid":true,"given":"Tufan","family":"\u00c7\u0131nar","sequence":"first","affiliation":[{"name":"Health Sciences University, Sultan Abd\u00fclhamid Han Training and Research Hospital, Department of Cardiology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veysel Ozan","family":"Tan\u0131k","sequence":"additional","affiliation":[{"name":"Ankara D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t Training and Research Hospital, Department of Cardiology, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"G\u00fcrkan","sequence":"additional","affiliation":[{"name":"Health Sciences University, Siyami Ersek Training and Research Hospital, Department of Cardiology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2020,5,17]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2370"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.06.054"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31817f9398"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1536\/jhj.45.441"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.11.032"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-004-0800-x"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.12.041"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1007\/bf02938394"},{"key":"R9","first-page":"33","article-title":"Lipid-free apolipoprotein A-I exerts an antioxidative role against cell-free hemoglobin","volume":"1","author":"Du R","year":"2012","journal-title":"Am J Clin Exp Immunol"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.054262"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362006"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.59.4.416"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744904"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.07.028"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2011.646"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.941"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2013\/5269.3123"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2017.07.026"}],"container-title":["Journal of Cardiovascular and Thoracic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-12-140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-12-140.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T08:59:45Z","timestamp":1593680385000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/Article\/jcvtr-28708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,17]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.34172\/jcvtr.2020.23","relation":{},"ISSN":["2008-5117","2008-6830"],"issn-type":[{"value":"2008-5117","type":"print"},{"value":"2008-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,17]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"}]}}