{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:46:18Z","timestamp":1740174378761,"version":"3.37.3"},"reference-count":21,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["jcvtr.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Thorac Res"],"published-print":{"date-parts":[[2022,12,31]]},"abstract":"<jats:p>Introduction: Since the coronavirus disease 2019 (COVID-19) pandemic, the use of angiotensin II receptor blockers (ARBs) in hypertensive patients with COVID-19 has been controversial. Following our previous study, after one year, we intended to extend our sample size and results to investigate the effects of ARBs with both in-hospital outcomes and 7-month follow-up results in patients with COVID-19. Methods: Patients with a diagnosis of COVID-19 who were admitted to Sina Hospital, Tehran, Iran, from February to October 2020 participated in this follow-up cohort study. The COVID-19 diagnosis was based on a positive polymerase chain reaction test or chest computed tomography scan according to guidelines. Patients were followed for disease severity, incurring in-hospital mortality, complications, and 7-month all-cause mortality. Results: We evaluated 1413 patients with COVID-19 in this study. After excluding 124 patients, 1289 including 561(43.5%) hypertensive patients, entered the analysis. During the study, 875(67.9%) severe disease, 227(17.6%) in-hospital mortality, and 307(23.8%) 7-month all-cause mortality were observed. After adjusting for possible confounders, ARB was not associated with severity, in-hospital and 7-month all-cause mortality, and in-hospital complications except for acute kidney injury. Discontinuation of ARBs was significantly associated with higher in-hospital mortality and 7-month all-cause mortality (both P values&lt;0.006). We observed a better 7-month outcome in those who continued their ARBs after discharge. Conclusion: The results of this study, along with the previous studies, provide reassurance that taking ARBs is not associated with the risk of mortality, complications, and poorer outcomes in hypertensive COVID-19 patients after adjustment for possible confounders.<\/jats:p>","DOI":"10.34172\/jcvtr.2022.30559","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T18:12:57Z","timestamp":1673201577000},"page":"253-257","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of angiotensin receptor blockers (ARBs) on clinical outcomes of patients with hypertension and COVID-19: A 7-month follow-up cohort study"],"prefix":"10.34172","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7503-8722","authenticated-orcid":true,"given":"Azar","family":"Hadadi","sequence":"first","affiliation":[{"name":"Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2559-0858","authenticated-orcid":true,"given":"Sina","family":"Kazemian","sequence":"additional","affiliation":[{"name":"Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahan","family":"Shafie","sequence":"additional","affiliation":[{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezoo","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Sina Hospital, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Soleimani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6687-995X","authenticated-orcid":true,"given":"Haleh","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30566-3"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1159\/000515714"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05985-9"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpab130"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0279-4"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(20)30116-8"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1282"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa076"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa149"},{"key":"R10","first-page":"e53","article-title":"Rationale and design of a registry in a referral and educational medical center in Tehran, Iran: Sina hospital COVID-19 registry (SHCo-19R)","volume":"4","author":"Talebpour M","year":"2020","journal-title":"Front Emerg Med"},{"key":"R11","unstructured":"World Health Organization (WHO). Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (2019-Ncov)Infection is Suspected: Interim Guidance, 28 January 2020. Geneva: WHO; 2020."},{"key":"R12","unstructured":"Anonymous. COVID-19 Epidemiology Committee. http:\/\/corona.behdasht.gov.ir\/. Accessed August 20, 2021."},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-020-00701-2"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1159\/000517581"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpab111"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa223"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaa168"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012690"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(20)30558-0"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.25864"},{"key":"R21","unstructured":"Anonymous. ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. https:\/\/www.escardio.org\/Education\/COVID-19-and-Cardiology\/ESC-COVID-19-Guidance. Accessed September 8, 2021."}],"container-title":["Journal of Cardiovascular and Thoracic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-14-253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-14-253.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T18:13:05Z","timestamp":1673201585000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/Article\/jcvtr-30559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,26]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,31]]},"published-print":{"date-parts":[[2022,12,31]]}},"URL":"https:\/\/doi.org\/10.34172\/jcvtr.2022.30559","relation":{},"ISSN":["2008-5117","2008-6830"],"issn-type":[{"type":"print","value":"2008-5117"},{"type":"electronic","value":"2008-6830"}],"subject":[],"published":{"date-parts":[[2022,11,26]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2022-04-22","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}