{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:46:20Z","timestamp":1740174380530,"version":"3.37.3"},"reference-count":36,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["jcvtr.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Thorac Res"],"published-print":{"date-parts":[[2023,9,23]]},"abstract":"<jats:p>Introduction: Hemodynamic disturbance is a common problem in patients undergoing thyroid surgery. It may be due to episodic increases in thyroid hormones (thyroid storm) or stimulation of the carotid sinus baroreflex. The aim of the present study was to investigate effectiveness of the pre-operative oral Clonidine on reducing these hemodynamic changes during total thyroidectomy surgery. Methods: In a prospective, randomized, double-blind study, 80 patients scheduled for elective total thyroidectomy were randomized to receive either 0.2 mg Clonidine (n=40) or a matched placebo (n=40) orally sixty minutes before entering the operating room. Hemodynamic variables, the duration of surgery, estimated amount of blood loss and the dose of administered remifentanil were recorded for further analysis. Results: Oral Clonidine was found to be significantly better in maintaining stable hemodynamics compared to the control group. Also, In the Clonidine group, the estimated amount of blood loss (110.4\u00b110 ml vs. 182.2\u00b111.4 mL, P=0.04), duration of the surgery (78.26\u00b155.2 min vs. 105.16\u00b161.75 min, P=0.027) and administered dose of remifentanil (26.67\u00b16.6 \u03bcg vs. 216.2\u00b114.8 \u03bcg, P=0.01) were also significantly lower than the control group. Conclusion: Pre-operative administration of 0.2 mg oral Clonidine in patients undergoing total thyroidectomy results in improved perioperative hemodynamic stability and reduced response to perioperative stress.<\/jats:p>","DOI":"10.34172\/jcvtr.2023.31680","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:31:55Z","timestamp":1697272315000},"page":"132-137","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of the oral Clonidine as a pre-anesthetic medicine for thyroidectomy surgery; A randomized clinical trial"],"prefix":"10.34172","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-2557","authenticated-orcid":true,"given":"Sepideh Sadat","family":"Zahedi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5089-1698","authenticated-orcid":true,"given":"Bahman","family":"Naghipour","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surur","family":"Zahedi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Zahedi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tabriz Azad University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ziaeddin","family":"Rasihashemi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2023,9,23]]},"reference":[{"key":"R1","first-page":"359","article-title":"[Current indications for thyroidectomy]","volume":"62","author":"Dionigi G","year":"2007","journal-title":"Minerva Chir"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9579-8"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1515\/iss-2021-0038"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_76_19"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.109671"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/bf03008287"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2017.02.003"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.76583"},{"key":"R9","first-page":"23","article-title":"Effect of oral clonidine premedication on perioperative hemodynamic response and postoperative analgesic requirement for patients undergoing laparoscopic cholecystectomy","volume":"38","author":"Sung CS","year":"2000","journal-title":"Acta Anaesthesiol Sin"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/43.6.531"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.14260\/jemds\/2015\/2231"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/0952-8180(94)00013-t"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2346.2001.0790e.x"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1097\/00001503-200210000-00007"},{"key":"R15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4103\/0970-9185.74581","article-title":"Clonidine in adults as a sedative agent in the intensive care unit","volume":"26","author":"Jamadarkhana S","year":"2010","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.18203\/2319-2003.ijbcp20160707"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.18410\/jebmh\/2020\/53"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.113984"},{"key":"R19","first-page":"157","article-title":"Irritation of the respiratory tract and its reflex effect upon heart","volume":"70","author":"Reid LC","year":"1940","journal-title":"Surg Gynecol Obstet"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/59.3.295"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00406-9"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.191113"},{"key":"R23","unstructured":"Nishikawa T, Taguchi M, Kimura T, Taguchi N, Sato Y, Dai M. 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