{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:10:15Z","timestamp":1785809415762,"version":"3.56.0"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["jcvtr.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Thorac Res"],"published-print":{"date-parts":[[2023,12,30]]},"abstract":"<jats:p>Introduction: Coronary artery disease (CAD) is the main cause of death and is characterized by atherosclerosis in coronary arteries. Inflammation plays a crucial role in the progression and development of atherosclerosis. Methods: The present study consisted of 132 Iranian individuals who underwent coronary angiography, 65 patients with CAD, and 67 controls. The matrix metalloproteinase-9 (MMP-9), TNF-\u03b1, IL-6, and vitamin D serum levels were measured by the ELISA technique. The gene expression of MMP-9 and tissue inhibitors of metalloproteinase (TIMP-1) was estimated by real-time PCR assay. Results: A considerable increase in levels and PBMC gene expression of MMP-9 and serum levels of IL-6 and TNF-\u03b1 were found in CAD patients compared with controls. A significant decrease was detected in vitamin D levels of CAD patients in comparison with controls. A considerable direct correlation was found between MMP-9 levels and MMP-9 and TIMP1 gene expression in CAD patients. MMP-9 levels positively correlated with LDL-C in CAD patients. The correlation between TIMP1 gene expression and IL-6 levels was also negatively significant. There were positive correlations between MMP-9 levels with IL-6 and TNF-\u03b1 serum levels in CAD patients. Conclusion: This study showed that the interaction between MMPs, TIMP1, and cytokines could play a role in the pathogenesis of atherosclerosis. The present study suggested that high levels of TNF-\u03b1 and IL-6 and vitamin D deficiency in our studied patients could disturb the MMP-9\/TIMP-1 balance and lipid metabolism, leading to plaque formation\/ rupture in predisposed CAD patients.<\/jats:p>","DOI":"10.34172\/jcvtr.2023.31844","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T07:24:02Z","timestamp":1705130642000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of MMP-9, IL-6, TNF-\u03b1 levels and peripheral blood mononuclear cells genes expression of MMP-9 and TIMP-1 in Iranian patients with coronary artery disease"],"prefix":"10.34172","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-7217","authenticated-orcid":true,"given":"Tooran","family":"Akbari","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toktam","family":"Kazemi Fard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Fadaei","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-6319","authenticated-orcid":true,"given":"Rahim","family":"Rostami","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nariman","family":"Moradi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monireh","family":"Movahedi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-6577","authenticated-orcid":true,"given":"Soudabeh","family":"Fallah","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2023,12,30]]},"container-title":["Journal of Cardiovascular and Thoracic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-15-223.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-15-223.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T07:24:02Z","timestamp":1705130642000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/Article\/jcvtr-31844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,30]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,12,30]]},"published-print":{"date-parts":[[2023,12,30]]}},"URL":"https:\/\/doi.org\/10.34172\/jcvtr.2023.31844","relation":{},"ISSN":["2008-5117","2008-6830"],"issn-type":[{"value":"2008-5117","type":"print"},{"value":"2008-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,30]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2023-04-17","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}