{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:01:09Z","timestamp":1785236469436,"version":"3.55.0"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["jcvtr.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Thorac Res"],"published-print":{"date-parts":[[2024,3,13]]},"abstract":"<jats:p>Introduction: The present study sought to compare the diagnostic accuracy and radiation dose of ECG-gated, ultra-fast, low-dose, high-pitch, spiral (FLASH) mode versus conventional, ECG-gated, sequential coronary artery calcium (CAC) scoring in patients with suspected coronary artery disease (CAD). Methods: The study included 120 patients who underwent both conventional scanning and FLASH mode scanning and were subdivided into derivation and validation cohorts. In the conventional sequential (step-and-shoot) protocol, prospective ECG-gated, non-contrast acquisition was performed at 70% of R-R interval. The spiral (FLASH) mode utilized a high-pitch and high-speed gantry rotation scanning mode where acquisition of the entire heart was done within a single cardiac cycle with prospective ECG-gating at 70% of R-R interval. Results: Correlation between CAC scores derived from conventional (cCAC) and FLASH mode (fCAC) in derivation cohort was excellent (r=0.99; P&lt;0.001). A linear regression model was used to develop a formula for deriving the estimated CAC score (eCAC) from fCAC (eCAC=0.978 x fCAC). In validation cohort, eCAC showed excellent agreement with cCAC (ICC=0.9983; 95%CI: 0.9972 - 0.9990). Excellent agreement for risk classification (weighted kappa=0.93898; 95%CI: 0.86833 - 1.0000) was observed with 95% (57\/60) scores falling within the same risk category. Effective dose was significantly lower in FLASH mode (conventional, 0.58\u00b10.21 mSv vs. FLASH, 0.34\u00b10.12 mSv; P&lt;0.0001). Conclusion: CAC scoring using FLASH mode is feasible with high accuracy and shows excellent agreement with conventional CAC scores at significantly reduced radiation doses. <\/jats:p>","DOI":"10.34172\/jcvtr.31736","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T08:23:55Z","timestamp":1710750235000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low-dose, high-pitch, spiral (FLASH) mode versus conventional sequential method for coronary artery calcium scoring: A derivation-validation study"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-8304","authenticated-orcid":true,"given":"Niraj Nirmal","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Radiology & Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayannika","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Radiology & Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Radiology & Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5605-8672","authenticated-orcid":true,"given":"Priya","family":"Jagia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Radiology & Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2024,3,13]]},"container-title":["Journal of Cardiovascular and Thoracic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-16-15.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/PDF\/jcvtr-16-15.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T08:23:56Z","timestamp":1710750236000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcvtr.tbzmed.ac.ir\/Article\/jcvtr-31736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,3,13]]},"published-print":{"date-parts":[[2024,3,13]]}},"URL":"https:\/\/doi.org\/10.34172\/jcvtr.31736","relation":{},"ISSN":["2008-5117","2008-6830"],"issn-type":[{"value":"2008-5117","type":"print"},{"value":"2008-6830","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2023-02-10","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}