{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:54:28Z","timestamp":1791143668789,"version":"4.1.0"},"reference-count":19,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["jcvtr.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Cardiovasc Thorac Res"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>Introduction: Fibrosis-4 (FIB-4) and fibrosis-5 (FIB-5) indices are non-invasive biomarkers originally developed for hepatic fibrosis but may reflect systemic pathophysiological changes related to adverse cardiovascular prognosis. We aimed to investigate whether baseline FIB-4 and FIB-5 values predict long-term mortality in patients with heart failure (HF). Methods: This retrospective observational study included 593 patients with HF who had available long-term mortality data. FIB-4 and FIB-5 indices were calculated at admission. Patients were followed for all-cause mortality, and outcomes were evaluated at 1-year, 3-year, and 5-year intervals. Clinical, laboratory, and echocardiographic parameters were compared between survivors and non-survivors. Results: During follow-up, 1-year, 3-year, and 5-year mortality rates were 24.6%, 39.0%, and 49.7%, respectively. Non-survivors had significantly higher FIB-4 and FIB-5 values compared with survivors (P&lt;0.001 for both). ROC curve analyses demonstrated that both indices had significant predictive performance for long-term mortality. Optimal cut-off values showed good sensitivity and specificity for identifying high-risk patients. Conclusion: Higher FIB-4 and FIB-5 values are associated with greater long-term mortality risk in HF patients. These indices may serve as practical, cost-effective prognostic biomarkers for mortality risk stratification in routine clinical care.<\/jats:p>","DOI":"10.34172\/jcvtr.33476","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:30:14Z","timestamp":1791142214000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Value of Fibrosis-4 Index with Long-Term Mortality in Patients with Heart Failure: A Comparison Study with Fibrosis-5 Index"],"prefix":"10.34172","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2620-9948","authenticated-orcid":true,"given":"Halit Emre","family":"Yalva\u00e7","sequence":"first","affiliation":[{"name":"Department of Cardiology, Eski\u015fehir City Hospital, Eski\u015fehir, 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