{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:17:07Z","timestamp":1740176227602,"version":"3.37.3"},"reference-count":21,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["journals.sbmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Lasers Med Sci"],"published-print":{"date-parts":[[2021,11,7]]},"abstract":"<jats:p>Introduction: Beh\u00e7et\u2019s disease (BD) is a debilitating and chronic vasculitis which can affect multiple organs. Recurrent oral aphthosis is the most common clinical feature of BD. The remarkable pain associated with painful oral ulcers can exert a major impact on the patients\u2019 quality of life. Relieving pain of these oral ulcers is an essential approach in the management of mucocutaneous lesions of BD. Non-thermal CO2 laser therapy (NTCLT) as a novel photobiomodulative approach has recently been used for significant and immediate pain reduction of some types of painful oral lesions such as recurrent aphthous stomatitis, pemphigus vulgaris, and so on. In this procedure by some considerations, the conventional CO2 laser is used as a non-surgical, non- thermal, photobiomodulative laser without any visible thermal adverse effects. In this article, we report our experiences about the analgesic effects of NTCLT on painful oral aphthous ulcers of BD. Case Presentation: We report four cases of BD, whose painful oral aphthous ulcers were irradiated with NTCLT. Immediately after NTCLT, the pain of the lesions was significantly relieved with no visible complications. Conclusion: The results of this study suggest that NTCLT could be proposed as a hopeful procedure for significant and instant pain relief of oral aphthous ulcers of BD without any visible thermal adverse effects.<\/jats:p>","DOI":"10.34172\/jlms.2021.72","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T07:36:01Z","timestamp":1638344161000},"page":"e72-e72","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Effect of Non-Thermal CO2 Laser Therapy (NTCLT) on Pain Relief of Oral Aphthous Ulcers of Beh\u00e7et\u2019s Disease"],"prefix":"10.34172","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2928-1921","authenticated-orcid":true,"given":"Nasrin","family":"Zand","sequence":"first","affiliation":[{"name":"Department of Medical Laser, Medical Laser Research Center, Yara institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Ataie-Fashtami","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Royan Institute for Stem Cell Biology & Technology, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9457-5299","authenticated-orcid":true,"given":"Parvin","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Research Vice-President of Medical Laser Research Center, Yara institute, Academic Center for Education, Culture and Research (ACECR), Tehran University of Medical Sciences (TUMS), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-6136","authenticated-orcid":true,"given":"Mohsen","family":"Fateh","sequence":"additional","affiliation":[{"name":"Research Fellow, Life Style & Health Management Department, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-8847","authenticated-orcid":true,"given":"Afshan","family":"Shirkavand","sequence":"additional","affiliation":[{"name":"Department of Medical Laser, Medical Laser Research Center, Yara institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"doi-asserted-by":"publisher","key":"R1","DOI":"10.1111\/1346-8138.13381"},{"doi-asserted-by":"publisher","key":"R2","DOI":"10.1080\/14397595.2018.1558752"},{"doi-asserted-by":"publisher","key":"R3","DOI":"10.1111\/1756-185X.13465"},{"doi-asserted-by":"publisher","key":"R4","DOI":"10.1093\/rheumatology\/kez626"},{"doi-asserted-by":"publisher","key":"R5","DOI":"10.1080\/1744666X.2016.1205486"},{"doi-asserted-by":"publisher","key":"R6","DOI":"10.23736\/S0026-4970.18.04135-3"},{"doi-asserted-by":"publisher","key":"R7","DOI":"10.1007\/s13317-016-0074-1"},{"doi-asserted-by":"publisher","key":"R8","DOI":"10.3349\/ymj.2007.48.4.573"},{"doi-asserted-by":"publisher","key":"R9","DOI":"10.1016\/j.semarthrit.2018.05.008"},{"doi-asserted-by":"publisher","key":"R10","DOI":"10.1093\/rheumatology\/keaa086"},{"doi-asserted-by":"publisher","key":"R11","DOI":"10.1002\/14651858.CD011018.pub2"},{"doi-asserted-by":"publisher","key":"R12","DOI":"10.1038\/sj.bmt.1704272"},{"doi-asserted-by":"publisher","key":"R13","DOI":"10.1016\/j.tripleo.2003.11.012"},{"doi-asserted-by":"publisher","key":"R14","DOI":"10.1007\/s10103-008-0555-1"},{"key":"R15","first-page":"6","article-title":"Analgesic effects of single session of Non-Ablative CO2 Laser Therapy (NACLT) on major aphthous ulcers: (a preliminary study)","volume":"6","author":"Zand N","year":"2009","journal-title":"Lasers Med"},{"doi-asserted-by":"publisher","key":"R16","DOI":"10.1089\/pho.2012.3301.Epub2012Oct31"},{"doi-asserted-by":"publisher","key":"R17","DOI":"10.1016\/j.oooo.2013.02.011.Epub2013Apr23"},{"key":"R18","first-page":"20","article-title":"The effect CO2 laser on reducing pain associated with aphthous stomatitis","volume":"18","author":"Rezvaninezhad R S","year":"2016","journal-title":"J Babol Univ Med Sci"},{"doi-asserted-by":"publisher","key":"R19","DOI":"10.15171\/jlms.2017.02"},{"doi-asserted-by":"publisher","key":"R20","DOI":"10.15171\/jlms.2020.18"},{"unstructured":"Tuner J, Hode L. 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