{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:27:52Z","timestamp":1792106872782,"version":"4.4.0"},"reference-count":40,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["journals.sbmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Lasers Med Sci"],"published-print":{"date-parts":[[2022,3,23]]},"abstract":"<jats:p>Introduction: Crossbite is a common malocclusion with a 7-23% prevalence rate. Treatment is based on the expansion of the mid-palatal suture (MPS) with Rapid Palatal Expansion(RPE) followed by a retention period to reach new bone maturation, enough to maintain the results stable. This systematic review was conducted to evaluate the effectiveness of low-level laser therapy (LLLT) in increasing bone formation in MPS. Methods: This article was written by the PRISMA checklist. Electronically, 3 databases, namely PubMed, Scopus, and Embase, were searched with the keywords selected based on PICO. Time (2010-2021) and language restrictions were performed. Results: 528 articles, out of which 374 studies were screened, were found, and 9 full-text articles were subsequently included considering these inclusion criteria: randomized clinical trial (RCT) that examines the efficacy of LLLT in rapid palatal expansion (RPE), age under 15 years, non-surgical RPE with a tooth-supported appliance, and low-intensity laser application. Finally, 4 articles were appraised by Cochrane version 5.2.0 with 7 domains. 3 of 4 articles showed LLLT has a significant impact on bone formation. One of them showed no significant difference in pain perception and bone density between the laser and non-laser groups. Conclusion: While many studies have assessed the effect of LLLT on bone formation in animal models, high-quality clinical trials are missing in this regard. The available clinical trials suggest a positive effect of LLLT on sutural bone formation after RPE.<\/jats:p>","DOI":"10.34172\/jlms.2022.13","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T08:10:16Z","timestamp":1660378216000},"page":"e13-e13","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of Low-Level Laser Therapy on Bone Formation in Rapid Palatal Expansion: A Systematic Review"],"prefix":"10.34172","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4964-9076","authenticated-orcid":true,"given":"Arash","family":"Farzan","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-4331","authenticated-orcid":true,"given":"Katayoon","family":"Khaleghi","sequence":"additional","affiliation":[{"name":"School of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-5562","authenticated-orcid":true,"given":"Zeynab","family":"Pirayesh","sequence":"additional","affiliation":[{"name":"Dental Student, Research Committee, Zanjan University of Medical Sciences, Zanjan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.32.1.h53g027713432102"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Aloufi F, Preston CB, Zawawi KH. Changes in the upper and lower pharyngeal airway spaces associated with rapid maxillary expansion. int sch res notices (Online) 2012;2012. doi:org\/10.5402\/2012\/290964.","DOI":"10.5402\/2012\/290964"},{"key":"R3","first-page":"E210","article-title":"Interceptive orthodontics: The need for early diagnosis and treatment of posterior crossbites","volume":"11","author":"Casta\u00f1er Peir\u00f3 A","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1080\/000164800750000658"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1043\/0003-3219(2004)074????"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1043\/0003-3219(2001)????"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2007.01.021"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2011.01534.x"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1590\/2177-6709.22.2.035-044.oar"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4970.19.04178-5"},{"key":"R11","first-page":"273","article-title":"Infrared laser therapy after surgically assisted rapid palatal expansion to diminish pain and accelerate bone healing","volume":"11","author":"Abreu MER","year":"2010","journal-title":"World J Orthod"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-1970-3"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-03141-9"},{"key":"R14","unstructured":"Sousa MVS. Lasers in Dentistry: Guide for Clinical Practice. Wiley-Blackwell; 2015."},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2017.03.004"},{"key":"R16","first-page":"78","article-title":"Effect of mesenchymal stem cells injection and low-level laser therapy on bone formation after rapid maxillary expansion: an animal study","volume":"9","author":"Mohaghegh S","year":"2020","journal-title":"Am J Stem Cells"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2020.S6"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0968-0"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513486899"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22560"},{"key":"R21","first-page":"9","article-title":"Efficacy of surgical and non-surgical interventions on accelerating orthodontic tooth movement: a systematic review","volume":"8","author":"Kalemaj Z","year":"2015","journal-title":"Eur J Oral Implantol"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1860-0"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2405"},{"key":"R24","doi-asserted-by":"crossref","unstructured":"Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane handbook for systematic reviews of interventions. John Wiley & Sons; 2019 Sep 23.","DOI":"10.1002\/9781119536604"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-1933-8"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2011.10.023"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.2319\/011209-22.1"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.4274\/meandros.88598"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.5624\/isd.2018.48.1.41"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Rozylo-Kalinowska I. Technical Errors and Artefacts in Dental Radiography. In: Imaging Techniques in Dental Radiology. Springer, Cham; 2020. https:\/\/doi.org\/10.1007\/978-3-030-41372-9_7.","DOI":"10.1007\/978-3-030-41372-9_7"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.5624\/isd.2018.48.2.79"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1069"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1089\/104454703322564479"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.2319\/033007-153.1"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2012.05.015"},{"key":"R36","first-page":"175","article-title":"Therapeutic laser in surgical procedures of pediatric dentistry","volume":"10","author":"Machado MAAM","year":"2010","journal-title":"J Oral Laser Appl"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1743-4"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1590\/2177-6709.21.6.115-125.sar"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.11.028"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2017.4278"}],"container-title":["Journal of Lasers in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sbmu.ac.ir\/jlms\/article\/view\/35015\/28960","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sbmu.ac.ir\/jlms\/article\/view\/35015\/28960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T08:10:24Z","timestamp":1660378224000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sbmu.ac.ir\/jlms\/article\/view\/35015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.34172\/jlms.2022.13","relation":{},"ISSN":["2008-9783","2228-6721"],"issn-type":[{"value":"2008-9783","type":"print"},{"value":"2228-6721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,23]]},"assertion":[{"value":"Laser Application in Medical Sciences Research Center","name":"journal_owner","label":"Journal Owner"},{"value":"Laser Application in Medical Sciences Research Center","name":"journal_publisher","label":"Journal Publisher"},{"value":"2021-05-26","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}