{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:19:22Z","timestamp":1792095562536,"version":"4.4.0"},"reference-count":35,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["journals.sbmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Lasers Med Sci"],"published-print":{"date-parts":[[2024,3,3]]},"abstract":"<jats:p>Introduction: In men, several factors cause infertility, among which we can mention damage to sperm due to high temperature. So far, various treatments have been proposed for it, but they have not been highly effective. The current study aimed to evaluate the effect of exosome therapy (EXO) and photobiomodulation therapy (PBMT) on spermatogenesis arrest in male mice after scrotum hyperthermia. Methods: In this experimental study, the animals were divided into four groups: control, scrotal hyperthermia, scrotal hyperthermia+EXO (100 \u03bcL\/d) (mice were treated for 30 days), scrotal hyperthermia+PBMT (laser of 0.03 J\/cm2 for 30 seconds\/for 30 days). Hyperthermia was induced by exposure to the temperature of 43 \u00b0C for 20 minute every day for 5 times. After 6 weeks, the animals were sacrificed. Results: The treated groups showed a significant increase in sperm parameters, as compared to the hyperthermic groups. Moreover, these favorable effects were observed in relation to the volume of testicular tissue, the number of germ cells, Leydig cells and Sertoli cells, and the level of testosterone. Research on antioxidants showed a significant reduction in oxidized glutathione (GSSG) and reactive oxygen species (ROS) in the treatment groups in comparison to the hyperthermia group (P&lt;0.001). Also, there has been a significant increase in the amount of hydrogen peroxide enzyme observed in the hyperthermia group as opposed to the treatment group (P&lt;0.001). Conclusion: These findings show that EXO and PBMT can improve spermatogenesis caused by hyperthermia, reduce ROS and GSSG, and increase glutathione (GSH) and sperm quality.<\/jats:p>","DOI":"10.34172\/jlms.2024.03","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T05:52:20Z","timestamp":1713592340000},"page":"e3","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Therapeutic Effects of Exosome Therapy and Photobiomodulation Therapy on the Spermatogenesis Arrest in Male Mice After Scrotum Hyperthermia"],"prefix":"10.34172","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4123-7524","authenticated-orcid":true,"given":"Fakhrosadat","family":"Tabatabaee","sequence":"first","affiliation":[{"name":"Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Darabi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Research Institute for Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Soltani","sequence":"additional","affiliation":[{"name":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fakhroddin","family":"Aghajanpour","sequence":"additional","affiliation":[{"name":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azar","family":"Afshar","sequence":"additional","affiliation":[{"name":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7157-1834","authenticated-orcid":true,"given":"Hojjat Allah","family":"Abbaszadeh","sequence":"additional","affiliation":[{"name":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-0751","authenticated-orcid":true,"given":"Hassan","family":"Rajabi-Maham","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa781"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.33594\/000000030"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19052713"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0663-y"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1186\/s12610-021-00152-6"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa002"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00288-2"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.5603\/FM.a2019.0022"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26577"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682x.182397"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00615-1"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.22122\/jims.v38i562.12770.[Persian]"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0372-8"},{"key":"R14","unstructured":"Jahangard Y, Moradi A, Mowla SJ. 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