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Methods: This study included a treated group, wherein 11 C. albicans isolates were obtained from the saliva of HNC patients undergoing radiotherapy at a dose exceeding 30 Gy. The control groups consisted of an untreated negative control and a positive control treated with nystatin. The treatment groups were subjected to LLLT in continuous mode for 50 seconds at a wavelength of 976 nm, 0.1 W at a dose of 5 J\/cm2 for Laser 1 (L1) group and 0.2 W at a dose of 10 J\/cm2 for Laser 2 (L2) group. The tests were conducted using C. albicans inoculum equivalent to a 0.5-McFarland suspension on 96-well plates. All test group inoculums were then cultured on Sabouraud dextrose agar (SDA), and the colony count was assessed at 104 CFU\/mL. Results: LLLT at 5 and 10 J\/ cm2 reduced C. albicans colonies by 7.01% and 10.94%, respectively, but the reductions were not statistically significant (P&gt;0.05). Nystatin eliminated all the colonies. Conclusion: LLLT shows potential for reducing C. albicans colonies in HNC patients undergoing radiotherapy. However, further studies with varied parameters and methods are necessary.<\/jats:p>","DOI":"10.34172\/jlms.2024.11","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T08:07:58Z","timestamp":1717056478000},"page":"e11","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>In Vitro<\/i> Effect of Low-level Laser Therapy on <i>Candida albicans<\/i> Colonies Isolated From Patients Undergoing Radiotherapy for Head and Neck Cancer"],"prefix":"10.34172","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7171-3185","authenticated-orcid":true,"given":"Novia Tri","family":"Hasanah","sequence":"first","affiliation":[{"name":"Oral Medicine Residency Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2506-5105","authenticated-orcid":true,"given":"Irna","family":"Sufiawati","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1262-8691","authenticated-orcid":true,"given":"Adji","family":"Kusumadjati","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Universitas Padjadjaran\/Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mas Adi","family":"Sunardi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Universitas Padjadjaran\/Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"R1","doi-asserted-by":"crossref","unstructured":"Beyzadeoglu M, Ozyigit G, Ebruli C. 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