{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:11:24Z","timestamp":1763536284019,"version":"3.37.3"},"reference-count":23,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["journals.sbmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Lasers Med Sci"],"published-print":{"date-parts":[[2024,7,27]]},"abstract":"<jats:p>Introduction: Psoriasis is a common autoimmune skin disease associated with genetically influenced chronic inflammation accompanied by remitting and deteriorating scaly skin. T-cell targeted biologics, IL-17 inhibitors, IL-12\/IL-23 inhibitors, TNF-\u03b1 inhibitors, PDE4 inhibitors, and ultraviolet (UV) radiation are applied to treat psoriasis. Efficacy evaluation of narrow band UVB (NB-UVB) radiation was the aim of this study. Methods: Data were extracted from Gene Expression Omnibus (GEO) and were pre-evaluated via the GEO2R program. The significant differentially expressed genes (DEGs) were included in the protein-protein interaction (PPI) network analysis. The hubs, bottlenecks, and hub-bottleneck DEGs were introduced as central genes. Activation, inhibition, and expression relationship between central genes were assessed to explore the critical individuals. Results: Among 513 analyzed significant DEGs, 22 hub-bottleneck genes were identified. Further analysis revealed that FN1, STAT3, HIF1A, IL1B, P4HB, SOD2, MMP2, and STAT1 were the crucial genes in psoriasis samples targeted by NB-UVB radiation. Conclusion: In conclusion, NB-UVB radiation as a treatment targets critical genes in peri-lesion skin tissue biopsy of psoriasis patients via a complicated mechanism. This therapeutic method downregulates STAT3, HIF1A, IL1B, and P4HB to treat psoriasis but downregulates STAT1 and SOD2 and upregulates MMP2 and FN1 to develop disease.<\/jats:p>","DOI":"10.34172\/jlms.2024.26","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T10:46:39Z","timestamp":1724323599000},"page":"e26","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy Evaluation of Treatment of Psoriasis Via Narrow Band-Ultraviolet Radiation"],"prefix":"10.34172","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2495-1831","authenticated-orcid":true,"given":"Mohammad","family":"Rostami Nejad","sequence":"first","affiliation":[{"name":"Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza M","family":"Robati","sequence":"additional","affiliation":[{"name":"Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-9501","authenticated-orcid":true,"given":"Zahra","family":"Razzaghi","sequence":"additional","affiliation":[{"name":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Arjmand","sequence":"additional","affiliation":[{"name":"Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Iranian Cancer Control Center (MACSA), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Montazer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Firoozabadi hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Bandarian","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farideh","family":"Razi","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Rezaei Tavirani","sequence":"additional","affiliation":[{"name":"Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199503023320907"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02310.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3386"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV119.007678"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189962"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2021.76"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2023.27"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2021.91"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.614195"},{"key":"R11","doi-asserted-by":"crossref","unstructured":"Ali A, Hulipalled VR, Patil SS. 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