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Methods: Each treatment sample received NIR therapy for 15 minutes per session on days 0, 1, 2, 3, and 5. Wound measurements were recorded, and blood samples were collected for laboratory testing to assess the effectiveness of laser therapy in postoperative wound healing. Meanwhile, the control group did not receive therapy but underwent wound measurements and blood sample collection. The data obtained were analyzed using the SPSS non-parametric Friedman test to compare the mean values of TNF-\u03b1, IL-1\u03b2, and TGF-\u03b21 expression between the control and therapy groups. The Mann-Whitney test followed this to determine whether there were significant differences between the groups. A significance level of P&lt;0.05 was used. Results: The use of NIR laser therapy in the treatment group resulted in a 35% reduction in wound length and a 46% reduction in wound width. In the control group, wound length decreased by 30%, while wound width decreased by 26%. These results indicate that NIR therapy is effective in tissue regeneration, as evidenced by the reduction in wound size due to granulation formation and re-epithelialization. Statistical analysis of laboratory assessments showed significant differences in IL-1\u03b2 and TGF-\u03b21 cytokine expression (P&lt;0.05) in the treatment group, while TNF-\u03b1 expression did not show a significant difference (P&gt;0.05) between the two groups. Conclusion: Clinical assessment shows that NIR has an effect on the formation of better wound tissue and shows good wound quality.<\/jats:p>","DOI":"10.34172\/jlms.2025.35","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T11:14:26Z","timestamp":1764242066000},"page":"e35","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of 808 nm Near Infrared (NIR) Laser Photobiomodulation for Accelerating Postoperative Wound Healing"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1534-6725","authenticated-orcid":true,"given":"Waode Erimelga","family":"Nurfitri","sequence":"first","affiliation":[{"name":"Department of Physics, Faculty of Science and Technology, Airlangga University, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-0792","authenticated-orcid":true,"given":"Suryani Dyah","family":"Astuti","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prihartini","family":"Widiyanti","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricky","family":"Wibowo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universitas Airlangga Hospital, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hery","family":"Wibowo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ubaya University, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deny","family":"Arifianto","sequence":"additional","affiliation":[{"name":"Department of Engineering, Faculty of Vocational, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winarno","family":"Winarno","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Khalil","family":"Yaqubi","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Nurdin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Halu Oleo, Kendari 93232, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasrul Anuar","family":"Abd Razak","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2019.07.371"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.12968\/bjcn.2021.26.Sup6.S22"},{"key":"R3","first-page":"94","article-title":"The activity of antibacterial agent of honey against Staphylococcus aureus","volume":"3","author":"Nadhilla NF","year":"2014","journal-title":"Journal Majority"},{"key":"R4","unstructured":"Komite Etik Kemenkes RI. 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