{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:56:45Z","timestamp":1777294605484,"version":"3.51.4"},"reference-count":25,"publisher":"Maad Rayan Publishing Company","content-domain":{"domain":["journals.sbmu.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Lasers Med Sci"],"published-print":{"date-parts":[[2026,2,14]]},"abstract":"<jats:p>Introduction: Molybdenum disulfide (MoS2), as an anticancer reagent, can absorb near-infrared (NIR) wavelengths in phototherapy. In the present study, the synergic effect of MoS2 (in nanostructure) and NIR radiation on human mesenchymal stem cells (hMSCs) was evaluated via protein-protein interaction (PPI) network analysis. Methods: Gene expression profiles of hMSCs were extracted from the Gene Expression Omnibus (GEO) database and analyzed via PPI network analysis. The validity of findings was assessed via the Kaplan-Meier Plotter. Results: FN1, ACTA2, CCL2, CXCL8, FBN1, and LEP genes were selected as hub genes among 121 recognized differentially expressed genes (DEGs) as the targeted genes by the synergic effects of MoS2 and NIR radiation. Kaplan-Meier Plotter analysis demonstrated that FN1 suppression by MoS2 and NIR radiation can significantly increase the overall survival of patients with gastric cancer, lung cancer, ovarian cancer, and myeloma. Conclusion: In conclusion, findings indicate that the anticancer property of MoS2 is intensified in the condition of NIR radiation. Therefore, MoS2 is a suitable photosensitizer reagent in photodynamic therapy.<\/jats:p>","DOI":"10.34172\/jlms.2026.04","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:54:16Z","timestamp":1777290856000},"page":"e4","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Synergic Effects of Molybdenum Disulfide Treatment and Near-Infrared Radiation on Human Mesenchymal Stem Cells"],"prefix":"10.34172","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8421-7538","authenticated-orcid":true,"given":"Alireza","family":"Omidi Farzin","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Modarres Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Arjmand","sequence":"additional","affiliation":[{"name":"Hematology-Oncology and Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology, and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Iranian Cancer Control Center (MACSA), Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nastaran","family":"Asri","sequence":"additional","affiliation":[{"name":"Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-9501","authenticated-orcid":true,"given":"Zahra","family":"Razzaghi","sequence":"additional","affiliation":[{"name":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farideh","family":"Razi","sequence":"additional","affiliation":[{"name":"Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Bandarian","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza M","family":"Robati","sequence":"additional","affiliation":[{"name":"Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"},{"name":"Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Vafaee","sequence":"additional","affiliation":[{"name":"Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parnia","family":"Rahnamay Farnood","sequence":"additional","affiliation":[{"name":"Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c01314"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1039\/d2tb00131d"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500655"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02985-y"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-021-02173-y"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86623-2"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.17816\/dv637416"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.2147\/ptt.S335913"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121535"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2025.1678483"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2024.14"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.34172\/jlms.2021.76"},{"key":"R13","first-page":"87","article-title":"Introducing critical common dysregulated proteins in esophageal, gastric, and intestinal cancers","volume":"15","author":"Arjmand B","year":"2022","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914345117"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.03.019"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.913659"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-022-01943-w"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-22-1897"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0161-z"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.02.001"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1177\/00368504251328754"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2021.06.009"},{"key":"R23","first-page":"7340","article-title":"FBN1 promotes DLBCL cell migration by activating the Wnt\/\u03b2-catenin signaling pathway and regulating TIMP1","volume":"12","author":"Wang H","year":"2020","journal-title":"Am J Transl Res"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-024-01573-6"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202008_22630"}],"container-title":["Journal of Lasers in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sbmu.ac.ir\/jlms\/article\/view\/50752\/37042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sbmu.ac.ir\/jlms\/article\/view\/50752\/37042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T11:54:17Z","timestamp":1777290857000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sbmu.ac.ir\/jlms\/article\/view\/50752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,14]]},"references-count":25,"URL":"https:\/\/doi.org\/10.34172\/jlms.2026.04","relation":{},"ISSN":["2008-9783","2228-6721"],"issn-type":[{"value":"2008-9783","type":"print"},{"value":"2228-6721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,14]]},"assertion":[{"value":"Shahid Beheshti University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Shahid Beheshti University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2025-11-01","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}