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Scleral temperature was monitored in real time using a thermal probe. On day 14, histological analysis assessed choroidal vascular thrombosis and stromal fibrosis using a semiquantitative scoring system. Retinal and scleral tissue damage was also evaluated. Results: The analysis accounting for inter-animal clustering revealed a significant association between chlorin e6 administration and choroidal vascular thrombosis (90% vs. 50%; adjusted OR=9.8, 95% CI: 1.4\u201368.9; P=0.021) and fibrosis (80% vs. 40%; adjusted OR=6.2, 95% CI: 1.1\u201335.0; P=0.039). Severity scores for thrombosis and fibrosis were also significantly higher in the TS-PDT group (P&lt;0.001 for both). No significant differences in scleral temperature (P\u22650.45) orretinal\/scleral damage were observed. Conclusion: Vascular damage during TS-PDT is primarily photochemical, mediated by chlorin e6. No significant intergroupdifferences were observed in monitored scleral surface temperaturesunder these parameters, arguing against a major contribution from differential surface heating. The method demonstrates short-term structuralpreservation of surrounding ocular tissues, supporting itspotential as an organ-preserving treatment for intraocular tumors.<\/jats:p>","DOI":"10.34172\/jlms.51515","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:41:20Z","timestamp":1792057280000},"page":"e51515","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chlorin e6 as a Photosensitizer for Inducing Targeted Effects in Transscleral Photodynamic Therapy"],"prefix":"10.34172","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-5712","authenticated-orcid":true,"given":"Elena Vladislavovna","family":"Samkovich","sequence":"first","affiliation":[{"name":"S. 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