{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:15:39Z","timestamp":1783383339353,"version":"3.54.6"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["joddd.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Dent Res Dent Clin Dent Prospects"],"published-print":{"date-parts":[[2025,12,31]]},"abstract":"<jats:p>Background. This study aimed to evaluate the effects of a single application of potassium iodide (KI), repeated daily applications of KI, and glutathione (GSH) on silver diamine fluoride (SDF)-induced tooth discoloration in primary canines. Methods. This in vitro study was performed on 36 extracted primary canines with dentinal caries, which were randomly assigned to four treatment groups: A (38% SDF alone), B (38% SDF+immediate single application of KI), C (38% SDF+repeated daily KI applications), and D (38% SDF+20% GSH). Color changes were measured at baseline and after 1, 14, and 30 days using a spectrophotometer and the CIEL*a*b* system. Statistical analysis included one-way ANOVA with post hoc Tukey tests for inter-group comparisons, and repeated-measures ANOVA with Bonferroni\u2019s correction for intra-group comparisons. Results. Significant differences in tooth discoloration (\u0394E) were observed between the study groups at all time intervals (P&lt;0.001). Group A showed the highest discoloration, while group D exhibited the lowest. Among the KI-treated groups, group B showed progressive discoloration over time, while group C demonstrated minimal changes, with no statistically significant differences between time intervals (P=0.435). Although groups C and D both showed reduced discoloration compared to group B, the difference between them was not statistically significant on day 30 (P=0.073). Conclusion. Repeated daily applications of KI or GSH effectively reduced SDF-induced tooth discoloration in primary canines. GSH showed the most favorable esthetic outcomes, suggesting its potential as a promising adjunct to SDF.<\/jats:p>","DOI":"10.34172\/joddd.025.43876","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:07:31Z","timestamp":1775286451000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of single and repeated potassium iodide applications versus glutathione on silver diamine fluoride-induced tooth discoloration in primary teeth: An in vitro comparative study"],"prefix":"10.34172","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-5539","authenticated-orcid":true,"given":"Maryam","family":"Hajiahmadi","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Dental Research Center, Faculty of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6676-6952","authenticated-orcid":true,"given":"Samira","family":"SadighBatha","sequence":"additional","affiliation":[{"name":"Dental Students\u2019 Research Committee, Department of Pediatric Dentistry, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7875-4572","authenticated-orcid":true,"given":"Mohammad Javad","family":"Tarrahi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2025,12,31]]},"container-title":["Journal of Dental Research, Dental Clinics, Dental Prospects"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joddd.tbzmed.ac.ir\/PDF\/joddd-19-215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joddd.tbzmed.ac.ir\/PDF\/joddd-19-215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T07:07:32Z","timestamp":1775286452000},"score":1,"resource":{"primary":{"URL":"https:\/\/joddd.tbzmed.ac.ir\/Article\/joddd-43876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,31]]},"published-print":{"date-parts":[[2025,12,31]]}},"URL":"https:\/\/doi.org\/10.34172\/joddd.025.43876","relation":{},"ISSN":["2008-210X","2008-2118"],"issn-type":[{"value":"2008-210X","type":"print"},{"value":"2008-2118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]},"assertion":[{"value":"Tabriz University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Tabriz University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2025-07-15","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}