{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:16:29Z","timestamp":1785147389332,"version":"3.55.0"},"reference-count":38,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["joddd.tbzmed.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Dent Res Dent Clin Dent Prospects"],"abstract":"<jats:p>\n            <jats:bold>Background.<\/jats:bold>  Various treatment modalities, such as leucocyte platelet-rich fibrin (L-PRF), bone grafts,and membranes, have been used for the restoration of lost periodontal tissues. Titanium-preparedplatelet-rich fibrin (T-PRF) has attracted attention for its proper haemocompatibility, thick fibrinmeshwork, and long resorption time. The present study aimed to evaluate the effectiveness of T-PRFand L-PRF in the management of intra-bony defects based on clinical and radiographic criteria. <jats:bold>Methods.<\/jats:bold>  Twenty-six subjects with 34 intra-bony 3- walled defects were divided into two groups (n=17)and treated with T-PRF or L-PRF. Clinical and radiographic measurements were recorded at baselineand 6- , 3- and 9- month intervals and tabulated on Microsoft Excel spreadsheets. For intra- and intergroupcomparisons, paired and unpaired t-tests were performed. P&lt;0.05 was set as statistically significant <jats:bold>Results.<\/jats:bold>  Intra-group comparisons revealed statistically significant differences (P&lt;0.05) from baseline inboth groups regarding clinical measurements. On intergroup comparison, the T-PRF group exhibited asignificantly higher defect fill compared to the L-PRF group (P&lt;0.05). <jats:bold>Conclusion.<\/jats:bold>  Within the limits of the present study, T-PRF seems to be a better alternative to L-PRF inthe treatment of intra-bony defects.<\/jats:p>","DOI":"10.34172\/joddd.2020.020","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T05:58:10Z","timestamp":1595311090000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Evaluation of titanium-prepared platelet-rich fibrin and leucocyteplatelet-rich fibrin in the treatment of intra-bony defects: Arandomized clinical trial"],"prefix":"10.34172","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3892-7322","authenticated-orcid":true,"given":"Shiva Shankar","family":"Gummaluri","sequence":"first","affiliation":[{"name":"Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-0597","authenticated-orcid":true,"given":"Hirak S","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6927-411X","authenticated-orcid":true,"given":"Madhusudan","family":"Astekar","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4464-8784","authenticated-orcid":true,"given":"Shivani","family":"Cheruvu","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Implantology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEB.2009.0562"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061347"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.29.s3.7.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.4103\/1305-7456.149653"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_678_18"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1327656"},{"key":"R7","first-page":"e55","article-title":"Une opportunit\u00e9 en paro-implantologie: le PRF","volume":"42","author":"Choukroun J","year":"2001","journal-title":"Implantodontie"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110075"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110705"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014759"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.03.017"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2012.08.003"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.008"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/209548"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_137_17"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12231"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080214"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.2.63"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01760.x"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2015.1035672"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160485"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2761-y"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.119279"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.4103\/0972-124X.194267"},{"key":"R28","unstructured":"Chacko NL, Abraham S, Rao HS, Sridhar N, Moon N, Barde DH. 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