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When a 5% cut-off point was set, ki-67 LI of all benign odontogenic tumors dropped below this point. All the malignant tumors demonstrated an LI of over 15.3%; a significantly higher Ki-67 LI in malignant odontogenic lesions (17.59\u00b12.80) was observed. Among benign tumors, the largest and the smallest Ki-67 LIs were seen in ameloblastoma (4.39\u00b10.47) and adenomatoid odontogenic tumor (0.91\u00b11.71). The mean values of Ki-67 LI in tumors and cysts were 4.23 (0.38) and 1.04 (0.07), respectively. Among odontogenic cysts, the highest Ki-67 LI was found in odontogenic keratocyst (OKC) (3.58\u00b10.51), and the lowest in the radicular cyst (1.29\u00b10.62%). Ki-67 LIs in all odontogenic cysts were &lt;3%, except for OKC. This controversial lesion seems to have a profile more similar to a tumor, and a treatment plan similar to tumors might be suggested. We found that odontogenic lesions have diverse proliferative activities that help differentiate between various lesions and suggest therapeutic plans.<\/jats:p>","DOI":"10.34172\/joddd.2021.012","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T15:10:40Z","timestamp":1620832240000},"page":"66-75","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Ki-67 expression as a diagnostic biomarker in odontogenic cysts and tumors: A systematic review and meta-analysis"],"prefix":"10.34172","volume":"15","author":[{"given":"Mahnaz","family":"Jabbarzadeh","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-4605","authenticated-orcid":true,"given":"Michael 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