{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T20:50:34Z","timestamp":1664484634324},"reference-count":35,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["journals.umsha.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Res Health Sci"],"published-print":{"date-parts":[[2021,5,19]]},"abstract":"<jats:p>Background: Currently, the worldwide prevalence and incidence of multidrug-resistant tuberculosis (MDR-TB) is drastically increasing. The main objective of this study was modeling the time-to-death of patients with MDR-TB at St. Peter\u2019s Specialized Hospital, Addis Ababa, Ethiopia, by using various parametric shared frailty models. Study Design: A retrospective study design was used. Methods: The study population was TB patients with MDR at St. Peter\u2019s Specialized Hospital from January 2016 through December 2019. Exponential, Weibull, and log-normal were used as baseline hazard functions with the gamma and inverse Gaussian frailty distributions. All the models were compared based on Akaike\u2019s Information Criteria. Results: The overall median time to death was 11 months and 123 (33.5%) patients died. Patients who lived in rural areas had shorter survival time than those who lived in urban areas with an accelerated factor of 0.135 (P=0.002). Patients with a history of anti-TB drug consumption had a short survival time than those without such a history with an accelerated factor of 0.02 (P=0.001). The variability (heterogeneity) of time to death of patients in the region for the selected model (Weibull-inverse Gaussian shared frailty model) was \u03b8=0.144 (P=0.027). Conclusion:  The MDR-TB patients with weight gain, khat and alcohol consumption, clinical complication of pneumothorax and pneumonia, extrapulmonary TB, and history of anti-TB drug consumption as well as those who lived in rural areas had a shorter survival time, compared to others. There was a significant heterogeneity effect in the St. Peter\u2019s Specialized Hospital. The best model for predicting the time to death of MDR-TB patients was Weibull-inverse Gaussian shared frailty model.<\/jats:p>","DOI":"10.34172\/jrhs.2021.50","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T10:42:01Z","timestamp":1635244921000},"page":"e00513-e00513","update-policy":"http:\/\/dx.doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Modeling Time to Death of Patients with Multidrug-Resistant Tuberculosis at Saint Peter\u2019s Specialized Hospital"],"prefix":"10.34172","volume":"21","author":[{"given":"Teramaj Wongel","family":"Wotale","sequence":"first","affiliation":[{"name":"Department of Statistics, College of Natural Science, Mettu University, Mettu, Oromia, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abiyot Negash","family":"Terefe","sequence":"additional","affiliation":[{"name":"Department of Statistics, College of Natural Science, Jimma University, Jimma, Oromia, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaleta Abdisa","family":"Fufa","sequence":"additional","affiliation":[{"name":"Department of Statistics, College of Natural Science, Jimma University, Jimma, Oromia, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"R1","unstructured":"World Health Organization. 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