{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:12:49Z","timestamp":1788498769304,"version":"build-2803163510"},"reference-count":33,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["jrhs.umsha.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Res Health Sci"],"published-print":{"date-parts":[[2022,10,19]]},"abstract":"<jats:p>Background: Human papillomavirus (HPV) infection is a major cause of cervical cancer worldwide. Knowledge of the geographical distribution and epidemiology of the most common HPV genotypes is a crucial step in developing prevention strategies. Therefore, this study aimed to investigate HPV genotype distribution among HPV-positive women and men in Tehran, Iran. Study Design: A case series study. Methods: The study was performed on 219 HPV-positive individuals (160 females and 59 males) from Tehran, Iran. Samples were obtained from the cervix and vagina of female subjects and the genital warts of male subjects. DNA was extracted from samples, and a polymerase chain reaction (PCR)-reverse dot blot genotyping chip was used to examine HPV genotypes. Formalin-fixed, paraffin-embedded tissue samples of 51 patients from the study population were also included in this study. Results: The proportion of high-risk (HR)-HPV was 67.12%. The most common HR-HPV types were HR-HPV16 (17.4%), HR-HPV68 (11.4%), and HR-HPV51 (7.8%). The most common low-risk (LR)-HPV types included LR-HPV6 (31.1%), LR-HPV81 (11.9%), and LR-HPV62 (11.4%). The highest prevalence of HPV was in the age group of\u2003&gt;\u200330 years (42.9%). Co-infection with multiple\u2003HR-HPV types was observed in\u200322.4%\u2003of\u2003specimens. Moreover, HR-HPV was found in 50% of women with normal cytology, 100% with a low-grade squamous intraepithelial lesion, and 84.61% with atypical squamous cells of undetermined significance. Conclusion: The results indicated the remarkable growth of HR-HPV68, which has rarely been reported in Iran. The findings add\u2003knowledge\u2003to\u2003HPV\u2003epidemiological\u2003investigation and emphasize the need for introducing educational programs in high schools and appropriate vaccination in Iran.<\/jats:p>","DOI":"10.34172\/jrhs.2022.88","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T06:18:41Z","timestamp":1691561921000},"page":"e00553","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence of Human Papillomavirus Genotypes in Tehran, Iran"],"prefix":"10.34172","volume":"22","author":[{"given":"Zahra","family":"Shalchimanesh","sequence":"first","affiliation":[{"name":"Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ghane","sequence":"additional","affiliation":[{"name":"Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Kalantar","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Allied Health Sciences, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20244"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2019.1578598"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.11769"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048-891X.2004.14418.x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1177\/172460080902400401"},{"key":"R6","first-page":"299","article-title":"Human papillomavirus: disease and laboratory diagnosis","volume":"54","author":"Swygart C","year":"1997","journal-title":"Br J Biomed Sci"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1822"},{"key":"R8","doi-asserted-by":"crossref","unstructured":"Gormley RH, Kovarik CL. 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