{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:09:15Z","timestamp":1749701355565,"version":"3.41.0"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["jrhs.umsha.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Res Health Sci"],"published-print":{"date-parts":[[2025,6,10]]},"abstract":"<jats:p>Background: Thyroid nodules are common endocrine disorders. Most nodules are benign, with only 5% to 15% being malignant. Fine needle aspiration (FNA) is a primary diagnostic method; however, recent studies have raised concerns about its diagnostic reliability. This study aimed to evaluate performance of FNA in diagnosing thyroid nodules using pathology results as the gold standard. Study Design: A cross-sectional study. Methods: This study analyzed patients who were referred to an endocrine clinic in Hamadan city and underwent thyroidectomy during a 10-year period. The collected data included demographics, clinical symptoms, FNA results, and pathological outcomes. Statistical analysis was conducted using Stata software, with the significance level set at 0.05. Results: The study included 700 patients, predominantly female (86.2%), with a mean age of 42.5 years. FNA results were as follows: non-diagnostic in 4.8% (n=43), benign in 43.4% (n=304), atypia of undetermined significance or follicular lesion of undetermined significance in 6.1% (n=42), follicular neoplasm in 13.2% (n=92), suspicious for malignancy in 22.8% (n=160), and malignant nodules in 9.7% (n=68) of the cases. Pathology revealed malignant nodules in 56.9% (n=398) of the cases, predominantly papillary carcinoma. Significant factors associated with malignancy included younger age, male gender, history of thyroid cancer in a first-degree relative, and the presence of cervical adenopathy. FNA showed a sensitivity of 72.43% (95% CI 67.58%, 76.93%) and a specificity of 89.64% (95% CI 85.46%, 92.95%), with an accuracy of 79.85% (95% CI 76.55%, 82.87%). Conclusion: While FNA is a valuable diagnostic tool for thyroid nodules, its sensitivity varies, necessitating close follow-up of patients with negative results. <\/jats:p>","DOI":"10.34172\/jrhs.7768","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:52:02Z","timestamp":1749635522000},"page":"e00658","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of Fine Needle Aspiration in Diagnosis of Thyroid Nodules at the Endocrine Clinic of Hamadan City During a 10-Year Period, Iran"],"prefix":"10.34172","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2658-7466","authenticated-orcid":true,"given":"Mahsa","family":"Zamiri Mofid","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Hamadan University Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-9304","authenticated-orcid":true,"given":"Erfan","family":"Ayubi","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidin","family":"Tarokhian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Hamadan University Medical Sciences, Hamadan, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-9872","authenticated-orcid":true,"given":"Shiva","family":"Borzouei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2025,6,10]]},"container-title":["Journal of Research in Health Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jrhs.umsha.ac.ir\/PDF\/jrhs-7768.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jrhs.umsha.ac.ir\/PDF\/jrhs-7768.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:52:02Z","timestamp":1749635522000},"score":1,"resource":{"primary":{"URL":"https:\/\/jrhs.umsha.ac.ir\/Article\/jrhs-7768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,10]]},"published-print":{"date-parts":[[2025,6,10]]}},"URL":"https:\/\/doi.org\/10.34172\/jrhs.7768","relation":{},"ISSN":["2228-7795","2228-7809"],"issn-type":[{"value":"2228-7795","type":"print"},{"value":"2228-7809","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"Hamadan University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Hamadan University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2024-11-08","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}