{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T12:13:00Z","timestamp":1775045580717,"version":"3.50.1"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["jrhs.umsha.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Res Health Sci"],"published-print":{"date-parts":[[2025,6,10]]},"abstract":"<jats:p>Background: The prevalence of iron-deficiency anemia (IDA) among school-aged children in India varies from 27% to 90%. There is no evidence of the comparative effects of various available interventions. Thus, this study aimed to quantify and rank the effects of different interventions on IDA among school-going children. Study Design: Systematic review and Meta-analysis. Methods: To this end, PubMed, Scopus, and ScienceDirect databases were searched, and randomized controlled trials (RCTs) evaluating the comparative effects of various interventions on hemoglobin (Hb) and serum ferritin against a control were included in this study. The random-effect model was conducted for Hb, and the fixed-effects model was performed for ferritin to estimate the mean difference (MD) and 95% confidence interval (CI) of the effect of interventions of outcomes based on the heterogeneity (I2 ). Results: Eight RCTs (including 2534 participants) investigating the effects of 12 interventions for IDA treatment among school-going children in India were obtained. The results of reference-based forest plots and P score indicated that iron-rich fish powder was the most effective intervention for increasing Hb levels (MD: 2.07 g\/dL, 95% CI: 0.68\u20133.47, P score=0.8656), followed by iron and folic acid (IFA) given twice weekly (MD: 1.47 g\/dL, 95% CI: -0.31\u20133.25, P score=0.7209). Additionally, IFA supplementation twice weekly was found to be highly effective in increasing serum ferritin levels among anemic school children (MD: 0.80 ng\/mL, 95% CI: 0.33\u20131.27, P score=0.9148). Conclusion: It seems that iron-rich fish powder and intermittent IFA supplementation were the most effective interventions, but further research is needed to confirm these results and assess their public health implications. Protocol Registration: PROSPERO registration number was CRD42024541802. <\/jats:p>","DOI":"10.34172\/jrhs.8985","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:51:30Z","timestamp":1749635490000},"page":"e00651","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Interventions on Iron-Deficiency Anemia Among School-Going Children in India: A Systematic Review and Network Meta-Analysis"],"prefix":"10.34172","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5980-8681","authenticated-orcid":true,"given":"Flemin","family":"Felix","sequence":"first","affiliation":[{"name":"Department of Health Systems Research, ICMR \u2013 National Institute of Traditional Medicine, Nehru Nagar, Belagavi, 590010, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-8764","authenticated-orcid":true,"given":"Kalesh Mappilakudy","family":"Karun","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR \u2013 National Institute of Traditional Medicine, Nehru Nagar, Belagavi, 590010, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan","family":"Nagendraswamy","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR \u2013 National Institute of Traditional Medicine, Nehru Nagar, Belagavi, 590010, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepthy Melepurakkal","family":"Sadanandan","sequence":"additional","affiliation":[{"name":"Women\u2019s and Children\u2019s Health Research Unit, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, 590010, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadu","family":"Damodaran","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, St. Thomas College, Palai, 686574, Kerala, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Barvaliya","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR \u2013 National Institute of Traditional Medicine, Nehru Nagar, Belagavi, 590010, Karnataka, India"},{"name":"Department of Health Research (Government of India), Model Rural Health Research Unit, Sirwar, Raichur, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subarna","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR \u2013 National Institute of Traditional Medicine, Nehru Nagar, Belagavi, 590010, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2025,6,10]]},"container-title":["Journal of Research in Health Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jrhs.umsha.ac.ir\/PDF\/jrhs-8985.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jrhs.umsha.ac.ir\/PDF\/jrhs-8985.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:51:30Z","timestamp":1749635490000},"score":1,"resource":{"primary":{"URL":"https:\/\/jrhs.umsha.ac.ir\/Article\/jrhs-8985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,10]]},"published-print":{"date-parts":[[2025,6,10]]}},"URL":"https:\/\/doi.org\/10.34172\/jrhs.8985","relation":{},"ISSN":["2228-7795","2228-7809"],"issn-type":[{"value":"2228-7795","type":"print"},{"value":"2228-7809","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"Hamadan University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Hamadan University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2025-01-21","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}