{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:09:15Z","timestamp":1749701355770,"version":"3.41.0"},"reference-count":0,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["jrhs.umsha.ac.ir"],"crossmark-restriction":false},"short-container-title":["J Res Health Sci"],"published-print":{"date-parts":[[2025,6,10]]},"abstract":"<jats:p>Background: Coronary artery disease (CAD) is a leading cause of death globally, with genetic and lifestyle factors contributing to its development. The first-degree relatives of CAD patients are at increased risk due to shared genetics and environments. This study aimed to perform a comparative analysis of gender-specific patterns of traditional CAD risk factors and QRISK3 scores in the first-degree relatives of CAD patients. Study Design: A cross-sectional study. Methods: This study enrolled 4,485 participants of first-degree relatives of patients who had been admitted to the hospital for CAD. Gender-specific comparisons were conducted in the first-degree relatives of CAD to assess traditional risk factors and QRISK3 scores. Results: The mean age of patients was 41.8 years, with males comprising 66% of participants in our study. Males exhibited more traditional risk factors, including higher systolic and diastolic blood pressure, dyslipidaemia, smoking, alcohol, junk food consumption, and oral tobacco use. Females had a higher prevalence of obesity, inadequate sleep, depression, and migraines. Males had a significantly higher 10-year CAD risk according to QRISK3 scores, reflecting an increased healthy heart age of 4.20\u00b11.32 years compared to their chronological age (P=0.0004). Conclusion: The prevalence of coronary risk factors was twice as high in the first-degree male relatives of individuals with known CAD compared to females. Distinct gender-based differences were found in risk factors and QRISK3 scores, highlighting the significance of specific approaches in evaluating and managing the risk of CAD within this high-risk group. <\/jats:p>","DOI":"10.34172\/jrhs.9005","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:51:46Z","timestamp":1749635506000},"page":"e00655","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Gender-Specific Patterns of Traditional Coronary Artery Disease Risk Factors and QRISK3 Scores in First-Degree Relatives of Coronary Artery Disease Patients"],"prefix":"10.34172","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3214-5787","authenticated-orcid":true,"given":"Meena","family":"Parmar","sequence":"first","affiliation":[{"name":"U.N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3654-2373","authenticated-orcid":true,"given":"Pooja","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, U.N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8613-6915","authenticated-orcid":true,"given":"Krutika","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Research, U.N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1208-4278","authenticated-orcid":true,"given":"Atisha","family":"Rana","sequence":"additional","affiliation":[{"name":"U.N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7071-0563","authenticated-orcid":true,"given":"Vijay","family":"Kalsariya","sequence":"additional","affiliation":[{"name":"U.N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuri","family":"Zadafiya","sequence":"additional","affiliation":[{"name":"U.N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2025,6,10]]},"container-title":["Journal of Research in Health Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jrhs.umsha.ac.ir\/PDF\/jrhs-9005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jrhs.umsha.ac.ir\/PDF\/jrhs-9005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:51:46Z","timestamp":1749635506000},"score":1,"resource":{"primary":{"URL":"https:\/\/jrhs.umsha.ac.ir\/Article\/jrhs-9005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,10]]},"published-print":{"date-parts":[[2025,6,10]]}},"URL":"https:\/\/doi.org\/10.34172\/jrhs.9005","relation":{},"ISSN":["2228-7795","2228-7809"],"issn-type":[{"value":"2228-7795","type":"print"},{"value":"2228-7809","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"Hamadan University of Medical Sciences","name":"journal_owner","label":"Journal Owner"},{"value":"Hamadan University of Medical Sciences","name":"journal_publisher","label":"Journal Publisher"},{"value":"2025-01-27","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}