{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:16:16Z","timestamp":1783347376266,"version":"3.54.6"},"reference-count":17,"publisher":"Maad Rayan Publishing Company","issue":"3","content-domain":{"domain":["mejdd.org"],"crossmark-restriction":false},"short-container-title":["Middle East J Dig Dis"],"published-print":{"date-parts":[[2021,6,10]]},"abstract":"<jats:p>BACKGROUND Systemic sclerosis (SSc) is a relatively common connective tissue disease, which is characterized by inflammation, progressive skin fibrosis, and injuries of small vessels, particularly in the lung and kidney. It seems that Helicobacter pylori (H. pylori) might contribute to the development of SSc as an extra-gastrointestinal autoimmune disease. We investigated the association between H. pylori infections and disease severity in patients with SSc. METHODS This is a cross-sectional study. Sampling method in this study was census method in such a way that all patients with SSc referred to Imam Reza Education and Research University Medical Center from May 2015 to August 2016 were included in the study. Finally, 74 patients were selected based on the inclusion criteria. Inclusion criteria were: 1. Definitive SSc based on American College of Rheumatology\/ European League Against Rheumatism 2010 (ACR\/EULAR) classification for scleroderma, which was diagnosed within the last two years. 2. Not taking any proton pump inhibitors. 3. Not taking any H. pylori treatment with a standard regimen within the recent 2 months. Disease severity was assessed and determined by two rheumatologists based on the Medsger\u2019s Disease Severity Scale (MDSS). H. pylori stool antigen was evaluated based on the test which sensitivity and specificity was proven. All obtained data were statistically analyzed by SPSS 16 using Fisher\u2019s exact test Spearman correlation test (RSpearman). RESULTS Forty one (55.4%) of the 74 patients had positive stool antigens. We found a significant positive association between the severity of disease based on MDSS and titer of H. pylori stool antigen (p \u2264 0.001). CONCLUSION This study reveals that H. pylori infection may play a significant role in the severity of organ involvement in SSc.<\/jats:p>","DOI":"10.34172\/mejdd.2021.232","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T05:51:02Z","timestamp":1643262662000},"page":"253-258","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Correlation between <i>Helicobacter Pylori<\/i> Infection and Disease Severity in Patients with Systemic Sclerosis"],"prefix":"10.34172","volume":"13","author":[{"given":"Elham","family":"Atabati","sequence":"first","affiliation":[{"name":"Clinical Research Development Unit, Valiasr Hospital, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaleh","family":"Shariati Sarabi","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hasan","family":"Jokar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Hashemzadeh","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Mirfeizi","sequence":"additional","affiliation":[{"name":"Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"R1","first-page":"67","article-title":"Parenchymal Lung Involvement in Patients with Systemic Sclerosis Admitted to Isfahan\u2019s Noor and Al-Zahra Hospitals","volume":"17","author":"Mottaghi P","year":"2010","journal-title":"RJMS"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.16-1-55"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20108"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31139"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i3.613"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201232.8"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.12.1117"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200203000-00004"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.022"},{"key":"R11","first-page":"S17","article-title":"Superantigens as immunogens and tolerogens","volume":"11","author":"Lobo-Yeo A","year":"1993","journal-title":"Clin Exp Rheumatol"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken505"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200211000-00011"},{"key":"R14","first-page":"25","article-title":"The effect of statins in treatment of Raynaud\u2019s phenomenon in sclero-derma: a case series","volume":"4","author":"Sahebari M","year":"2016","journal-title":"J Case Rep"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1159\/000131502"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.2217\/fca.11.75"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i36.12839"}],"container-title":["Middle East Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/download\/2269\/2209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/download\/2269\/2209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T05:51:05Z","timestamp":1643262665000},"score":1,"resource":{"primary":{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/view\/2269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,10]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,7]]}},"URL":"https:\/\/doi.org\/10.34172\/mejdd.2021.232","relation":{},"ISSN":["2008-5249"],"issn-type":[{"value":"2008-5249","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,10]]},"assertion":[{"value":"Iranian Association of Gastroenterology and Hepatology","name":"journal_owner","label":"Journal Owner"},{"value":"Iranian Association of Gastroenterology and Hepatology","name":"journal_publisher","label":"Journal Publisher"},{"value":"2020-11-14","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}