{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:40:21Z","timestamp":1780450821704,"version":"3.54.1"},"reference-count":18,"publisher":"Maad Rayan Publishing Company","issue":"1","content-domain":{"domain":["mejdd.org"],"crossmark-restriction":false},"short-container-title":["Middle East J Dig Dis"],"published-print":{"date-parts":[[2023,1,30]]},"abstract":"<jats:p>Background: Liver biopsy remain as the gold standard for diagnosing hepatic fibrosis; however, it has some limitations, such as life-threatening complications, low acceptance by the patients, and variations in the related sample. Therefore, there is a need for the development of non-invasive investigations for diagnosing hepatic fibrosis. Vibration-controlled transient elastography (VCTE) is one of these non-invasive methods.Methods: This study included 73 patients suffering from non-alcoholic fatty liver disease (NAFLD) who were older than 18 years. The patients underwent VCTE at the Baqiatallah and Firoozgar hospitals. Then, they underwent a liver biopsy by an experienced radiologist in the same hospital. A receiver operating characteristic (ROC) curve of different fibrosis stages was used to evaluate the VCTE verification. Results: VCTE could detect any fibrosis levels (stage 1 and higher) with an area under the ROC curve (AUROC) of 0.381. Moreover, it detected stage 2-4 fibrosis with an AUROC of 0.400, stage 3-4 fibrosis with an AUROC of 0.687, and stage 4 fibrosis with an AUROC of 0.984. Conclusion: The VCTE has high clinical validity in diagnosing the advanced stages of fibrosis (stages 3, 4) and can be a suitable alternative to the invasive method of liver biopsy with high reliability.<\/jats:p>","DOI":"10.34172\/mejdd.2023.316","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T11:27:32Z","timestamp":1681817252000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diagnostic Accuracy of Vibration Controlled Transient Elastography as Non-invasive Assessment of Liver Fibrosis in Patients with Non-alcoholic Fatty Liver Disease"],"prefix":"10.34172","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-8217","authenticated-orcid":true,"given":"Hossain","family":"Salehi","sequence":"first","affiliation":[{"name":"Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Mohammad","family":"Salehi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Hamadan University of Medical Sciences School of Medicine, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ebrahim","family":"Ghamarchehreh","sequence":"additional","affiliation":[{"name":"Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Khanlarzadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Hamadan University of Medical Sciences School of Medicine, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5688-2776","authenticated-orcid":true,"given":"Masoud Reza","family":"Sohrabi","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"R1","unstructured":"Feldman M, Friedman LS, Brandt LJ. 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Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease. 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