{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:31:00Z","timestamp":1740177060824,"version":"3.37.3"},"reference-count":27,"publisher":"Maad Rayan Publishing Company","issue":"4","content-domain":{"domain":["mejdd.org"],"crossmark-restriction":false},"short-container-title":["Middle East J Dig Dis"],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:p>Background: Among environmental factors, infectious agents, including Helicobacter pylori, can act as triggers for autoimmune thyroid diseases. Therefore, this study aimed to investigate the correlation between autoimmune Hashimoto\u2019s thyroiditis with H. pylori infection. Methods: The participants in this case-control study were 74 individuals 17-62 years who were divided into two groups, including 38 diagnosed Hashimoto\u2019s thyroiditis patients from an outpatient clinic of endocrinology and 36 apparently healthy individuals that were selected from family members of cases group age-matched and sex-matched. For individuals in two groups, a questionnaire was completed, including demographic information. Then, they were referred to the laboratory for thyroid stimulating hormone (TSH) and free T4 (FT4) in the control group and anti-thyroid peroxidase antibody (TPO-Ab) levels measurement in case and control groups. Stool samples were obtained from all individuals for H. pylori antigen detection using the ELIZA kit. Results: There was no significant difference in the mean age of case and control groups (P=0.96), and 81.1% of individuals were female. 58.6% of patients with Hashimoto\u2019s thyroiditis and 41.4% of the control group had positive H. pylori, but there was no statistically significant difference between the two groups (P=0.34). Furthermore, there was a significant positive correlation between TPO-Ab levels and H. pylori infection (r=0.2, P=0.03). Conclusion: TPO-Ab levels were associated with H. pylori infection diagnosed by H. pylori antigen.<\/jats:p>","DOI":"10.34172\/mejdd.2024.397","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:16:14Z","timestamp":1734956174000},"page":"230-234","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation between Autoimmune Hashimoto\u2019s Thyroiditis and <i>Helicobacter pylori<\/i> Infection: A Case-Control Study"],"prefix":"10.34172","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7515-6279","authenticated-orcid":true,"given":"Mahla","family":"Shajari","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-001X","authenticated-orcid":true,"given":"Maryam","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6112-7131","authenticated-orcid":true,"given":"Fereshteh","family":"Osmani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Health, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-9351","authenticated-orcid":true,"given":"Ebrahim","family":"Shafaie","sequence":"additional","affiliation":[{"name":"School of Medicine, Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-256X","authenticated-orcid":true,"given":"Zoya","family":"Tahergorabi","sequence":"additional","affiliation":[{"name":"Geriatric Health Research Center, Department of Physiology, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"20123","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00092"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1036"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2019.44833"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.3390\/genes12020222"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1159\/000324442"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1172\/jci12673"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12165"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v4.i1.5"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327745"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2224-4778.2014.07.03"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.11.1573"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2701"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-1615-z"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.101634"},{"key":"R16","first-page":"8007","article-title":"Association between Helicobacter pylori infection and autoimmune Hashimoto\u2019s thyroiditis","volume":"73","author":"Abo El Azaim NG","year":"2018","journal-title":"Egypt J Hosp Med"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.26574\/maedica.2019.14.2.98"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.32007\/jfacmedbagdad.591171"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071008"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1684074"},{"key":"R21","first-page":"293","article-title":"The association of Helicobacter pylori infection with Hashimoto\u2019s thyroiditis","volume":"51","author":"Aghili R","year":"2013","journal-title":"Acta Med Iran"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.4103\/ejim.ejim_2_19"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.15406\/ghoa.2016.04.00111"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1400371"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.58743"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.4385"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0041"}],"container-title":["Middle East Journal of Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/view\/3053\/2378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/view\/3053\/2378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:16:16Z","timestamp":1734956176000},"score":1,"resource":{"primary":{"URL":"http:\/\/mejdd.org\/index.php\/mejdd\/article\/view\/3053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,30]]}},"URL":"https:\/\/doi.org\/10.34172\/mejdd.2024.397","relation":{},"ISSN":["2008-5249"],"issn-type":[{"type":"print","value":"2008-5249"}],"subject":[],"published":{"date-parts":[[2024,10,30]]},"assertion":[{"value":"Iranian Association of Gastroerterology and Hepatology","name":"journal_owner","label":"Journal Owner"},{"value":"Iranian Association of Gastroerterology and Hepatology","name":"journal_publisher","label":"Journal Publisher"},{"value":"2024-04-10","order":1,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}