{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T08:44:09Z","timestamp":1792053849154,"version":"4.4.0"},"reference-count":19,"publisher":"Maad Rayan Publishing Company","issue":"2","content-domain":{"domain":["mejdd.org"],"crossmark-restriction":false},"short-container-title":["Middle East J Dig Dis"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Introduction: Dyspepsia severely affects patients\u2019 well-being and quality of life. The effect of psychosocial factors on symptom severity and generation, particularly their impact on clinical management, warrants further investigation. Thus, this study aimed to assess quality of life (QoL) in patients with functional dyspepsia. Methods: This was a comparative study on a sample of patients with dyspepsia and a comparison group. The diagnosis of dyspepsia was based on the Rome IV criteria, and the Short Form Health Survey (SF-36) was used to compare QoL between the study samples by performing analysis of covariance (ANCOVA). Results: The patient group had a lower QoL, and P values were significant in all subscales and components. Pearson\u2019s Chi-square test was significant only for pain-relief medication use (P&lt;0.001). P value of Pearson\u2019s Chi-square was 0.054 and 0.88, respectively, for smoking and alcohol use variables. Conclusion: The findings demonstrated that functional dyspepsia affects both physical and psychological health and decreases QoL.<\/jats:p>","DOI":"10.34172\/mejdd.3399","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:46:48Z","timestamp":1792050408000},"page":"82-85","update-policy":"https:\/\/doi.org\/10.34172\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life in Patients with Functional Dyspepsia: A Comparative Study"],"prefix":"10.34172","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6143-4350","authenticated-orcid":true,"given":"Zahra","family":"Momayez Sanat","sequence":"first","affiliation":[{"name":"Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Majidirad","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Rehabilitation Sciences, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Ebadati Nakhjiri","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5198-9539","authenticated-orcid":true,"given":"Ali","family":"Montazeri","sequence":"additional","affiliation":[{"name":"Health Metrics Research Center, Institute for Health Sciences Research, ACECR, Tehran, Iran"},{"name":"Faculty of Humanity Sciences, University of Science and Culture, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"20123","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Murison R, Milde AM. 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