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\u0441\u043a\u043b\u0435\u0440\u043e\u0437\u0430. \u041d\u0430\u043b\u0438\u0447\u0438\u0435 \u044d\u0442\u0438\u0445 \u0434\u0432\u0443\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0443 \u043e\u0434\u043d\u043e\u0433\u043e \u0438 \u0442\u043e\u0433\u043e \u0436\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430 \u0432\u0441\u0442\u0440\u0435\u0447\u0430\u0435\u0442\u0441\u044f \u043a\u0440\u0430\u0439\u043d\u0435 \u0440\u0435\u0434\u043a\u043e. \u041d\u0438 \u043e\u0434\u043d\u043e \u0438\u0437 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u0439 \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437\u0430 I \u0442\u0438\u043f\u0430, \u044f\u0432\u043b\u044f\u044e\u0449\u0435\u0433\u043e\u0441\u044f \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438 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\u043c\u0430\u0433\u043d\u0438\u0442\u043d\u043e-\u0440\u0435\u0437\u043e\u043d\u0430\u043d\u0441\u043d\u044b\u0445 \u0438 \u043a\u043e\u043c\u043f\u044c\u044e\u0442\u0435\u0440\u043d\u044b\u0445 \u0442\u043e\u043c\u043e\u0433\u0440\u0430\u043c\u043c, \u0440\u0435\u043d\u0442\u0433\u0435\u043d\u043e\u0433\u0440\u0430\u043c\u043c. \u0412\u044b\u043f\u043e\u043b\u043d\u0435\u043d \u043e\u0431\u0437\u043e\u0440 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u043d\u044b\u0445 \u0434\u0430\u043d\u043d\u044b\u0445, \u0441\u043e\u0433\u043b\u0430\u0441\u043d\u043e \u043a\u043e\u0442\u043e\u0440\u044b\u043c \u043e\u043f\u0438\u0441\u0430\u043d \u0440\u044f\u0434 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u0439 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0441\u043e\u0447\u0435\u0442\u0430\u043d\u0438\u0435\u043c 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\u043e\u0444\u0442\u0430\u043b\u044c\u043c\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438 \u0434\u0440\u0443\u0433\u0438\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u0438, \u0447\u0430\u0441\u0442\u043e \u0432\u044b\u044f\u0432\u043b\u044f\u0435\u043c\u044b\u0435 \u043e\u0441\u043b\u043e\u0436\u043d\u0435\u043d\u0438\u044f. \u041f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u044b \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u0430\u0441\u043f\u0435\u043a\u0442\u044b \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043d\u0435\u0439\u0440\u043e\u0444\u0438\u0431\u0440\u043e\u043c\u0430\u0442\u043e\u0437\u0430 1.<\/jats:p>\n                                                                                            <jats:p>ThearticledescribestheclinicalobservationofapatientwithacombinationoftypeIneurofibromatosis and multiple sclerosis. The presence of these two diseases in the same patient is extremely rare. None of the clinical manifestations of type I neurofibromatosis, which is a genetically determined disease, is associated with demyelination, while the central link in the pathogenesis of multiple sclerosis is the destruction of the myelin sheath of the axons of the central nervous system. A detailed analysis of the course of the patients disease was carried out, indicating the complications that developed. For visual assessment, illustrations of magnetic resonance and computed tomograms, radiographs are attached. A review of the literature data has been performed, according to which a number of clinical observations of patients with a combination of type I neurofibromatosis and multiple sclerosis are described. Information is given on the genetic nature of a hereditary disease: the neurofibromatosis I gene encodes a protein neurofibromin, which has a pro-oncogenic effect. Possible pathogenetic mechanisms of the combined occurrence of these diseases in the same patient are considered. The main diagnostic criteria are clinical symptoms recommended by the International Committee of Experts on Neurofibromatosis, and dermatological, ophthalmic and other manifestations of the disease, often identified complications, are also described in detail. The modern aspects of the diagnosis and treatment of neurofibromatosis I are presented.<\/jats:p>","DOI":"10.34883\/pi.2020.10.1.051","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T11:03:32Z","timestamp":1649847812000},"page":"127-138","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Observation of a Combination of Neurofibromatosis Type I and Multiple Sclerosis"],"prefix":"10.34883","author":[{"given":"\u042e.\u041d.","family":"\u0420\u0443\u0448\u043a\u0435\u0432\u0438\u0447","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0421.\u0410.","family":"\u041b\u0438\u0445\u0430\u0447\u0435\u0432","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u041b.\u0412.","family":"\u041a\u043e\u0441\u0442\u043e\u043f\u0440\u0430\u0432\u043e\u0432\u0430","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0414.\u0412.","family":"\u041d\u0430\u0443\u043c\u0435\u043d\u043a\u043e","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0422.\u0413.","family":"\u0413\u0432\u0438\u0449","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0421.\u0413.","family":"\u041a\u043b\u044e\u043d\u0447\u0438\u043a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34055","reference":[{"key":"1","unstructured":"Ufimtseva M., BochkarevYu., Halperin A. (2016) Kozhnyye proyavleniya bolezni Reklingkhauzena. Sovremennyye problemy nauki i obrazovaniya, no 6."},{"key":"2","unstructured":"Schneider N., Gorelov A. (2007) Neyrofibromatozpervogotipa (bolezn&rsquo; Reklingkhauzena). Sibirskoye meditsinskoye obozreniye, no 3."},{"key":"3","unstructured":"Pazhigova Z., Karpov S., Shevchenko P. (2014) Rasprostranennost&rsquo; rasseyannogoskleroza v mire (obzornayastat&rsquo;ya). Mezhdunarodnyy zhurnal eksperimental&rsquo;nogo obrazovaniya, no 1&ndash;2, pp. 78&ndash;82."},{"key":"4","unstructured":"Voskresenskaya O., Schmidt T., Alekseeva A. (2019) Sochetaniyerasseyannogosklerozaineyrofibromatoza I tipa, ostavalos&rsquo; nediagnostirovannym s rannegodetstva. Prakticheskaya pediatriya [Practical Pediatrics], vol. 14, no 3, pp. 45&ndash;50."},{"key":"5","unstructured":"Johnson M.R., Ferner R.E., Bobrow M., Hughes R.A.C. (2009) Detal&rsquo;nyy analiz gena miyelinovogo glikoproteina oligodendrotsitov u chetyrekh patsiyentov s neyrofibromatozom 1 i pervichnym progressiruyushchim rasseyannym sklerozom. J NeurolNeurosurgPsikhiatriya, vol. 6, no 5, pp. 643&ndash;646."},{"key":"6","doi-asserted-by":"crossref","unstructured":"Perini P., Gallo P. (2001) Spektr rasseyannogo skleroza svyazan s neyrofibromatozom tipa 1. J. Neurol. Neurosurg. Psikhiatriya, vol. 71, pp. 679&ndash;681.","DOI":"10.1136\/jnnp.71.5.679"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Etemadifar M., Fatehi F., Sahraian M.A. (2009) Rasseyannyy skleroz i neyrofibromatoz tipa 1: soobshcheniye o semi patsiyentakh iz Irana. Zhurnal rasseyannogo skleroza, vol. 15, no 9, pp. 1126&ndash;1130.","DOI":"10.1177\/1352458509106612"},{"key":"8","unstructured":"Alfonso S., Rocker J., Pou A. (1996) Rasseyannyy skleroz i neyrofibromatoz 1. Nevrologiya (Barselona, Ispaniya), vol. 11, no 6, pp. 233&ndash;235."},{"key":"9","unstructured":"Mustafin R.N., Bermisheva M.A., Khusnutdinova E.K. (2012) Kompleksnyy podkhod k izucheniyu osobennostey neyrofibromatoza 1 tipa. Kreativnaya khirurgiya i onkologiya, no 1, pp. 98&ndash;102."},{"key":"10","unstructured":"Kvasnitsky N. (2001) Neurofibromatosis 1. Ukrainskiy neyrokhirurgicheskiy zhurnal, no 4, pp. 13&ndash;24."},{"key":"11","doi-asserted-by":"crossref","unstructured":"Ars E., Kruer H., Morell M. (2003) Rekurrentnyye mutatsii v gene NF1 rasprostraneny sredi patsiyentov s neyrofibromatozom tipa 1. J. Med. Genetta, no 40, p. 82.","DOI":"10.1136\/jmg.40.6.e82"},{"key":"12","unstructured":"Ferner R.E., Huson S.M., Thomas N. (2006) Rukovodstvo po diagnostike i lecheniyu lits s neyrofibromatozom 1. J. 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