{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T09:11:22Z","timestamp":1649754682550},"reference-count":0,"publisher":"Professionals Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:p>\u041b\u0435\u0447\u0435\u043d\u0438\u0435 \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0430 (Ps) \u2013 \u043e\u0434\u043d\u0430 \u0438\u0437 \u0441\u0430\u043c\u044b\u0445 \u0437\u043b\u043e\u0431\u043e\u0434\u043d\u0435\u0432\u043d\u044b\u0445 \u043f\u0440\u043e\u0431\u043b\u0435\u043c \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0439 \u0434\u0435\u0440\u043c\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438. \u041a \u043d\u0430\u0441\u0442\u043e\u044f\u0449\u0435\u043c\u0443 \u0432\u0440\u0435\u043c\u0435\u043d\u0438 \u043f\u0440\u0435\u0434\u043b\u043e\u0436\u0435\u043d\u043e \u0431\u043e\u043b\u0435\u0435 100 \u043c\u0435\u0442\u043e\u0434\u043e\u0432 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 Ps, \u043d\u043e \u043d\u0438 \u043e\u0434\u0438\u043d \u0438\u0437 \u043d\u0438\u0445 \u043d\u0435 \u043c\u043e\u0436\u0435\u0442 \u0433\u0430\u0440\u0430\u043d\u0442\u0438\u0440\u043e\u0432\u0430\u0442\u044c \u043f\u043e\u043b\u043d\u043e\u0435 \u0438\u0437\u043b\u0435\u0447\u0435\u043d\u0438\u0435. \u0414\u043b\u044f \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u044f \u043c\u0430\u043a\u0441\u0438\u043c\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u044d\u0444\u0444\u0435\u043a\u0442\u0430 \u0432\u0440\u0430\u0447 \u0434\u043e\u043b\u0436\u0435\u043d \u0432\u044b\u0431\u0440\u0430\u0442\u044c \u043f\u0440\u0430\u0432\u0438\u043b\u044c\u043d\u0443\u044e \u043b\u0435\u0447\u0435\u0431\u043d\u0443\u044e \u0442\u0430\u043a\u0442\u0438\u043a\u0443, \u043a\u043e\u0442\u043e\u0440\u0430\u044f \u043e\u0431\u044f\u0437\u0430\u043d\u0430 \u043d\u043e\u0441\u0438\u0442\u044c \u043f\u0435\u0440\u0441\u043e\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440 \u0438 \u0443\u0447\u0438\u0442\u044b\u0432\u0430\u0442\u044c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043d\u044b\u0435, \u0433\u0435\u043d\u0434\u0435\u0440\u043d\u044b\u0435, \u0442\u0440\u0438\u0433\u0433\u0435\u0440\u043d\u044b\u0435 \u0444\u0430\u043a\u0442\u043e\u0440\u044b, \u0442\u0438\u043f \u0438 \u0442\u044f\u0436\u0435\u0441\u0442\u044c \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f, \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0438 \u0440\u0435\u0433\u0440\u0435\u0441\u0441\u0430 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0430 \u0436\u0438\u0437\u043d\u0438, \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u043b\u043e\u043a\u0430\u043b\u0438\u0437\u0430\u0446\u0438\u0438 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430, \u0431\u0435\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0438 \u043b\u0430\u043a\u0442\u0430\u0446\u0438\u044e. \u0422\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430, \u0432 \u043e\u0442\u043b\u0438\u0447\u0438\u0435 \u043e\u0442 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u0438 UV-\u0442\u0435\u0440\u0430\u043f\u0438\u0438, \u043c\u043e\u0433\u0443\u0442 \u0438 \u0434\u043e\u043b\u0436\u043d\u044b \u043f\u0440\u0438\u043c\u0435\u043d\u044f\u0442\u044c\u0441\u044f \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432, \u0441\u0442\u0440\u0430\u0434\u0430\u044e\u0449\u0438\u0445 Ps, \u043d\u0430 \u0432\u0441\u0435\u0445 \u0441\u0442\u0430\u0434\u0438\u044f\u0445 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u0430, \u0430 \u0442\u0430\u043a\u0436\u0435 \u0432 \u043c\u0435\u0436\u0440\u0435\u0446\u0438\u0434\u0438\u0432\u043d\u044b\u0439 \u043f\u0435\u0440\u0438\u043e\u0434 \u0434\u043b\u044f \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u044f \u0440\u0435\u043c\u0438\u0441\u0441\u0438\u0438.\u0412 \u043f\u0440\u0435\u0434\u044b\u0434\u0443\u0449\u0438\u0445 \u0447\u0430\u0441\u0442\u044f\u0445 \u0441\u0442\u0430\u0442\u044c\u0438 \u0440\u0430\u0441\u0441\u043c\u043e\u0442\u0440\u0435\u043d\u044b \u043e\u0431\u0449\u0438\u0435 \u043f\u0440\u0438\u043d\u0446\u0438\u043f\u044b \u043c\u0435\u0441\u0442\u043d\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438, \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0438 \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0441\u0442\u0435\u0440\u043e\u0438\u0434\u043e\u0432 (\u0422\u041a\u0421), \u044d\u043c\u043e\u043b\u043b\u0435\u043d\u0442\u043e\u0432, \u043a\u0435\u0440\u0430\u0442\u043e\u043b\u0438\u0442\u0438\u043a\u043e\u0432, \u0434\u0440\u0443\u0433\u0438\u0445 \u043a\u043e\u0441\u043c\u0435\u0446\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u0440\u0435\u0434\u0441\u0442\u0432, \u0432\u043e\u043f\u0440\u043e\u0441\u044b \u0443\u0445\u043e\u0434\u0430 \u0437\u0430 \u043a\u043e\u0436\u0435\u0439 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u0430, \u0441\u0442\u0440\u0430\u0434\u0430\u044e\u0449\u0435\u0433\u043e Ps [211, 212].\u041d\u0430\u0441\u0442\u043e\u044f\u0449\u0438\u0439 \u043c\u0430\u0442\u0435\u0440\u0438\u0430\u043b \u043f\u043e\u0441\u0432\u044f\u0449\u0435\u043d \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u043c \u0441\u0440\u0435\u0434\u0441\u0442\u0432\u0430\u043c, \u043f\u0440\u0435\u0434\u043b\u043e\u0436\u0435\u043d\u043d\u044b\u043c \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0430\u043d\u0442\u0438\u043f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0435\u043b\u044c\u043d\u043e \u043d\u0435\u0434\u0430\u0432\u043d\u043e, \u2013 \u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0430\u043d\u0430\u043b\u043e\u0433\u0430\u043c \u0432\u0438\u0442\u0430\u043c\u0438\u043d\u0430 D (\u0422\u0410\u0412\u0414), \u043a\u043e\u043c\u0431\u0438\u043d\u0430\u0446\u0438\u0438 \u0422\u0410\u0412\u0414 + \u0422\u041a\u0421, \u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0440\u0435\u0442\u0438\u043d\u043e\u0438\u0434\u0430\u043c (\u0422\u0420), \u0430 \u0442\u0430\u043a\u0436\u0435 \u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0438\u043d\u0433\u0438\u0431\u0438\u0442\u043e\u0440\u0430\u043c \u043a\u0430\u043b\u044c\u0446\u0438\u043d\u0435\u0432\u0440\u0438\u043d\u0430 (\u0422\u0418\u041a), \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u043d\u0435 \u0438\u043c\u0435\u044e\u0442 \u043e\u0444\u0438\u0446\u0438\u0430\u043b\u044c\u043d\u044b\u0445 \u043f\u043e\u043a\u0430\u0437\u0430\u043d\u0438\u0439 \u043a \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044e \u043f\u0440\u0438 Ps, \u043d\u043e \u043f\u0440\u0438\u0437\u043d\u0430\u043d\u044b \u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u043e\u043c \u0430\u0432\u0442\u043e\u0440\u0438\u0442\u0435\u0442\u043d\u044b\u0445 \u0433\u0430\u0439\u0434\u043e\u0432 \u0438 \u0440\u0443\u043a\u043e\u0432\u043e\u0434\u0441\u0442\u0432 \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u0430\u043b\u044c\u0442\u0435\u0440\u043d\u0430\u0442\u0438\u0432\u043d\u044b\u0445 \u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0441\u0442\u0435\u0440\u043e\u0438\u0434\u0430\u043c \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432. \u041f\u043e\u043a\u0430\u0437\u0430\u043d\u044b \u0440\u043e\u043b\u044c \u0438 \u043c\u0435\u0441\u0442\u043e \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0432 \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0445 \u0443\u0441\u043b\u043e\u0432\u0438\u044f\u0445 \u00ab\u043a\u043b\u0430\u0441\u0441\u0438\u0447\u0435\u0441\u043a\u0438\u0445\u00bb \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0435 \u043a\u0430\u043c\u0435\u043d\u043d\u043e\u0443\u0433\u043e\u043b\u044c\u043d\u043e\u0439 \u0441\u043c\u043e\u043b\u044b \u0438 \u0434\u0438\u0442\u0440\u0430\u043d\u043e\u043b\u0430. \u0422\u0430\u043a\u0442\u0438\u043a\u0430 \u0432\u044b\u0431\u043e\u0440\u0430 \u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u043f\u0440\u0438 \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0435 \u0440\u0430\u0437\u043e\u0431\u0440\u0430\u043d\u0430 \u0441 \u0443\u0447\u0435\u0442\u043e\u043c \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0445 \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u0435\u043d\u0438\u0439 \u043e \u0435\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u0438 \u0431\u0435\u0437\u043e\u043f\u0430\u0441\u043d\u043e\u0441\u0442\u0438. \u041e\u0441\u0432\u0435\u0449\u0435\u043d\u044b \u0432\u043e\u043f\u0440\u043e\u0441\u044b \u043f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u0441\u0438\u043d\u0442\u0435\u0437\u0430 \u043d\u043e\u0432\u044b\u0445 \u0442\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0430\u043d\u0442\u0438\u043f\u0441\u043e\u0440\u0438\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043b\u0435\u043a\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0445 \u0441\u0440\u0435\u0434\u0441\u0442\u0432.<\/jats:p>\n                                                                                            <jats:p>Treatment of psoriasis (Ps) is one of the most pressing problems of modern dermatology. Right now, there are more than 100 therapeutic methods of psoriasis treatment, but none of them can guarantee a complete cure. To obtain the maximum effect, the doctor must choose the right treatment tactics, which must be personalized taking into account age, gender, trigger factors, the type and severity of the disease, regression indicators of the quality of life, the localization of the pathological process, pregnancy and lactation. Topical agents, unlike systemic drugs and UV-therapy, can and should be used in patients suffering from psoriasis at all stages of the pathological process, as well as in the interrecurrent period to maintain remission.In the previous parts of the article, the general principles of local therapy, the possibilities and features of the use of topical corticosteroids (TCS), emollients, keratolytics, and other cosmeceutical agents were considered as well as issues of skin care for patients suffering from psoriasis [211, 212].This article is devoted to drugs that have been proposed as antipsoriatic drugs relatively recently \u2013 vitamin D analogues (VDA), a combination of VDA + TCS, topical retinoids (TR); as well as topical calcineurin inhibitors (TCIs), which are not officially indicated for psoriasis, but are recognized by most competent guidelines as alternative anti- inflammatory drugs instead of topical corticosteroids. Also, in this article discussed the role and application sites of so-called classical medications that are based on coal tar and dithranol in nowadays conditions. The tactics of choosing topical therapy for psoriasis is analyzed taking into account modern ideas about its effectiveness and safety. The issues of perspective synthesis of new topical antipsoriatic medicines are covered.<\/jats:p>","DOI":"10.34883\/pi.2022.8.1.008","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T08:52:16Z","timestamp":1649753536000},"page":"8-26","source":"Crossref","is-referenced-by-count":0,"title":["Topical Therapy of Psoriasis. Part III"],"prefix":"10.34883","author":[{"given":"\u0410.\u041c.","family":"\u041b\u0443\u043a\u044c\u044f\u043d\u043e\u0432","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"34055","container-title":["\u0414\u0435\u0440\u043c\u0430\u0442\u043e\u0432\u0435\u043d\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f \u041a\u043e\u0441\u043c\u0435\u0442\u043e\u043b\u043e\u0433\u0438\u044f"],"original-title":["\u0422\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u043f\u0441\u043e\u0440\u0438\u0430\u0437\u0430. \u0427\u0430\u0441\u0442\u044c III"],"language":"ru","deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T08:52:17Z","timestamp":1649753537000},"score":1,"resource":{"primary":{"URL":"https:\/\/recipe.by\/wp-content\/uploads\/2022\/04\/08-26_derm-1-2022-v8.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,5]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,4,5]]}},"URL":"https:\/\/doi.org\/10.34883\/pi.2022.8.1.008","relation":{},"ISSN":["2411-8982","2414-3707"],"issn-type":[{"value":"2411-8982","type":"print"},{"value":"2414-3707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,5]]}}}