{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:15:18Z","timestamp":1770678918595,"version":"3.49.0"},"reference-count":30,"publisher":"Saint Petersburg Institute of Bioregulation and Gerontology","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:p>\u0412 \u0443\u0441\u043b\u043e\u0432\u0438\u044f\u0445 \u0441\u0442\u0430\u0440\u0435\u043d\u0438\u044f \u043c\u0435\u043d\u044f\u044e\u0442\u0441\u044f \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u0449\u0438\u0442\u043e\u0432\u0438\u0434\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b, \u043f\u0440\u0438\u0447\u0435\u043c \u043f\u0440\u0438 \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0438 \u044d\u0442\u0438 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u044b \u0432 \u0431\u043e\u043b\u044c\u0448\u0435\u0439 \u0441\u0442\u0435\u043f\u0435\u043d\u0438 \u0438 \u0447\u0430\u0441\u0442\u043e \u043f\u0440\u0438\u0432\u043e\u0434\u044f\u0442 \u043a \u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u0438 \u0449\u0438\u0442\u043e\u0432\u0438\u0434\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b \u043a \u0422\u0422\u0413 \u0438 \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0443 \u0442\u0438\u0440\u0435\u043e\u0438\u0434\u043d\u044b\u0445 \u0433\u043e\u0440\u043c\u043e\u043d\u043e\u0432 (\u0422\u0413). \u041e\u0434\u043d\u0438\u043c \u0438\u0437 \u043f\u043e\u0434\u0445\u043e\u0434\u043e\u0432 \u0434\u043b\u044f \u043a\u043e\u043c\u043f\u0435\u043d\u0441\u0430\u0446\u0438\u0438 \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0430 \u0422\u0413 \u043c\u043e\u0436\u0435\u0442 \u0441\u0442\u0430\u0442\u044c \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u0430\u043b\u043b\u043e\u0441\u0442\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0430\u0433\u043e\u043d\u0438\u0441\u0442\u043e\u0432 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0430 \u0422\u0422\u0413, \u0432 \u0442\u043e\u043c \u0447\u0438\u0441\u043b\u0435 \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u0430\u043d\u043d\u043e\u0433\u043e \u043d\u0430\u043c\u0438 \u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f TPY3m. \u0426\u0435\u043b\u044c \u0440\u0430\u0431\u043e\u0442\u044b \u2014 \u0438\u0437\u0443\u0447\u0435\u043d\u0438\u0435 \u0435\u0433\u043e \u0432\u043b\u0438\u044f\u043d\u0438\u044f \u043d\u0430 \u0442\u0438\u0440\u0435\u043e\u0438\u0434\u043d\u044b\u0439 \u0441\u0442\u0430\u0442\u0443\u0441 \u0443 \u0441\u0442\u0430\u0440\u0435\u044e\u0449\u0438\u0445 (18 \u043c\u0435\u0441) \u0441\u0430\u043c\u0446\u043e\u0432 \u043a\u0440\u044b\u0441 Wistar \u0441 \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0435\u043c \u0438 \u0431\u0435\u0437 \u043d\u0435\u0433\u043e \u0432 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0438 \u0441 \u0442\u0438\u0440\u043e\u043b\u0438\u0431\u0435\u0440\u0438\u043d\u043e\u043c (\u0422\u0420\u0413), \u043f\u043e\u0432\u044b\u0448\u0430\u044e\u0449\u0438\u043c \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0422\u0422\u0413 \u0432 \u043a\u0440\u043e\u0432\u0438. \u041e\u0436\u0438\u0440\u0435\u043d\u0438\u0435 \u0432\u044b\u0437\u044b\u0432\u0430\u043b\u0438 12-\u043d\u0435\u0434\u0435\u043b\u044c\u043d\u043e\u0439 \u0432\u044b\u0441\u043e\u043a\u043e\u0436\u0438\u0440\u043e\u0432\u043e\u0439 \u0434\u0438\u0435\u0442\u043e\u0439 (\u0441 15-\u043c\u0435\u0441\u044f\u0447\u043d\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430), TPY3m \u0432\u0432\u043e\u0434\u0438\u043b\u0438 \u0432 \u0434\u043e\u0437\u0435 20 \u043c\u0433\/\u043a\u0433 (\u0432\/\u0431), \u0422\u0420\u0413 \u2014 \u0432 \u0434\u043e\u0437\u0435 100 \u043c\u043a\u0433 \u043d\u0430 \u043a\u0440\u044b\u0441\u0443 (\u0438\u043d\u0442\u0440\u0430\u043d\u0430\u0437\u0430\u043b\u044c\u043d\u043e), \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0441\u0432\u043e\u0431\u043e\u0434\u043d\u043e\u0433\u043e \u0442\u0438\u0440\u043e\u043a\u0441\u0438\u043d\u0430 (fT4), \u0441\u0432\u043e\u0431\u043e\u0434\u043d\u043e\u0433\u043e \u0438 \u043e\u0431\u0449\u0435\u0433\u043e \u0442\u0440\u0438\u0439\u043e\u0434\u0442\u0438\u0440\u043e\u043d\u0438\u043d\u0430 (fT3, tT3) \u0438 \u0422\u0422\u0413 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u044f\u043b\u0438 \u0441 \u043f\u043e\u043c\u043e\u0449\u044c\u044e \u0418\u0424\u0410. \u0423 \u0441\u0442\u0430\u0440\u0435\u044e\u0449\u0438\u0445 \u043a\u0440\u044b\u0441 \u0431\u0435\u0437 \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u044f (\u041a18) \u0437\u043d\u0430\u0447\u0438\u043c\u044b\u0445 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0439 \u0442\u0438\u0440\u0435\u043e\u0438\u0434\u043d\u043e\u0433\u043e \u0441\u0442\u0430\u0442\u0443\u0441\u0430 \u0432 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u0438 \u0441 \u043c\u043e\u043b\u043e\u0434\u044b\u043c\u0438 \u043a\u0440\u044b\u0441\u0430\u043c\u0438 (5 \u043c\u0435\u0441, \u041a5) \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u043e \u043d\u0435 \u0431\u044b\u043b\u043e, \u0437\u0430 \u0438\u0441\u043a\u043b\u044e\u0447\u0435\u043d\u0438\u0435\u043c \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u044f \u0443\u0440\u043e\u0432\u043d\u044f fT3. \u0423 \u0441\u0442\u0430\u0440\u0435\u044e\u0449\u0438\u0445 \u0436\u0438\u0432\u043e\u0442\u043d\u044b\u0445 \u0441 \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0435\u043c (\u041e\u041618) \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u041a18 \u0441\u043d\u0438\u0436\u0430\u043b\u0441\u044f \u0443\u0440\u043e\u0432\u0435\u043d\u044c fT4 \u0438 fT3, \u043f\u043e\u0432\u044b\u0448\u0430\u043b\u0441\u044f (\u043d\u0430 76 %) \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0422\u0422\u0413, \u0441\u043d\u0438\u0436\u0430\u043b\u0441\u044f (\u043d\u0430 58 %) \u0438\u043d\u0442\u0435\u0433\u0440\u0430\u043b\u044c\u043d\u044b\u0439 \u0442\u0438\u0440\u0435\u043e\u0438\u0434\u043d\u044b\u0439 \u0438\u043d\u0434\u0435\u043a\u0441, \u0447\u0442\u043e \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u0435\u0442 \u043e\u0431 \u043e\u0441\u043b\u0430\u0431\u043b\u0435\u043d\u0438\u0438 \u0441\u0438\u043d\u0442\u0435\u0437\u0430 \u0422\u0413 \u0438 \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u0438 \u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u0438 \u0449\u0438\u0442\u043e\u0432\u0438\u0434\u043d\u043e\u0439 \u0436\u0435\u043b\u0435\u0437\u044b \u043a \u0422\u0422\u0413. \u0422\u0420\u0413 \u043f\u043e\u0432\u044b\u0448\u0430\u043b \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0422\u0413 \u0438 \u0422\u0422\u0413 \u0432\u043e \u0432\u0441\u0435\u0445 \u0433\u0440\u0443\u043f\u043f\u0430\u0445. \u041e\u0434\u043d\u0430\u043a\u043e \u0422\u0420\u0413-\u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0439 \u043f\u0440\u0438\u0440\u043e\u0441\u0442 \u0443\u0440\u043e\u0432\u043d\u044f fT4 \u0432 \u0433\u0440\u0443\u043f\u043f\u0435 \u041a18+\u0422\u0420\u0413 \u0431\u044b\u043b \u043d\u0438\u0436\u0435, \u0447\u0435\u043c \u0432 \u041a5+\u0422\u0420\u0413, \u0430 \u0432 \u0433\u0440\u0443\u043f\u043f\u0435 \u041e\u041618+\u0422\u0420\u0413 \u043e\u043d \u0431\u044b\u043b \u043d\u0438\u0436\u0435, \u0447\u0435\u043c \u0432 \u041a18+\u0422\u0420\u0413. \u0412 \u0433\u0440\u0443\u043f\u043f\u0435 \u041e\u041618+\u0422\u0420\u0413 \u0442\u0430\u043a\u0436\u0435 \u0431\u044b\u043b\u0430 \u043e\u0442\u043c\u0435\u0447\u0435\u043d\u0430 \u0442\u0435\u043d\u0434\u0435\u043d\u0446\u0438\u044f \u043a \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u044e \u0422\u0420\u0413-\u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u043f\u0440\u0438\u0440\u043e\u0441\u0442\u0430 fT3. \u0412 \u0442\u043e \u0436\u0435 \u0432\u0440\u0435\u043c\u044f, \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0438\u0439 \u044d\u0444\u0444\u0435\u043a\u0442 TPY3m \u043d\u0430 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0422\u0413 \u0432\u043e \u0432\u0441\u0435\u0445 \u0433\u0440\u0443\u043f\u043f\u0430\u0445 \u0436\u0438\u0432\u043e\u0442\u043d\u044b\u0445 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0437\u043e\u0432\u0430\u043b\u0441\u044f \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u044c\u044e \u0438 \u043d\u0435 \u0437\u0430\u0432\u0438\u0441\u0435\u043b \u043e\u0442 \u0434\u0438\u0435\u0442\u044b \u0438 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430. \u042d\u0442\u043e \u0443\u043a\u0430\u0437\u044b\u0432\u0430\u0435\u0442 \u043d\u0430 \u0442\u043e, \u0447\u0442\u043e \u0432\u0435\u043b\u0438\u0447\u0438\u043d\u0430 \u0441\u0442\u0438\u043c\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0438\u0445 \u044d\u0444\u0444\u0435\u043a\u0442\u043e\u0432 TPY3m \u043d\u0430 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0422\u0413 \u0438 \u0447\u0443\u0432\u0441\u0442\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0441\u0442\u044c \u043a \u043d\u0435\u043c\u0443 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u0432 \u0422\u0422\u0413 \u0443 \u043a\u0440\u044b\u0441 \u0441\u043e\u0445\u0440\u0430\u043d\u044f\u044e\u0442\u0441\u044f \u0441 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043e\u043c \u0438 \u043f\u0440\u0438 \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0438, \u0432\u0441\u043b\u0435\u0434\u0441\u0442\u0432\u0438\u0435 \u0447\u0435\u0433\u043e TPY3m \u043c\u043e\u0436\u0435\u0442 \u0431\u044b\u0442\u044c \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d \u0434\u043b\u044f \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u043a\u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432, \u043d\u0430\u043f\u0440\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0445 \u043d\u0430 \u043a\u043e\u043c\u043f\u0435\u043d\u0441\u0430\u0446\u0438\u044e \u0434\u0435\u0444\u0438\u0446\u0438\u0442\u0430 \u0422\u0413 \u043f\u0440\u0438 \u0441\u0442\u0430\u0440\u0435\u043d\u0438\u0438 \u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u0430\u0445.<\/jats:p>\n                  <jats:p>In conditions of aging, the functions of the thyroid gland (TG) change, and in obesity these changes are expressed to a greater extent and often lead to the resistance of the TG to the thyroid-stimulating hormone (TSH) and a deficiency of thyroid hormones (TH). One of the approaches to compensate for the TH defi ciency may be the use of allosteric agonists of the TSH receptor, including the compound TPY3m developed by us. The aim of the work was to study its effect on the thyroid status in aging (18 months) male Wistar rats with and without obesity in comparison with thyroliberin (TRH), which increases the level of TSH in the blood. Obesity was induced by a 12-week high-fat diet (from the age of 15 months), TPY3m was administered at a dose of 20 mg\/kg (i.p.), and TRH at a dose of 100 \u03bcg\/rat (intranasally). The levels of free thyroxine (fT4), free and total triiodothyronine (fT3, tT3) and TSH were determined using ELISA. In aging rats without obesity (\u042118), no significant changes in thyroid status were found compared to young rats (5 months, \u04215), with the exception of a decrease in the fT3 level. In aging obese animals (OB18), compared to \u042118, the levels of fT4 and fT3 were decreased, the level of TSH was increased (by 76%), and the integrated thyroid index (ITI) was decreased (by 58%), which indicates a weakening of TH synthesis and the development of thyroid resistance to TSH. TRH increased the levels of TH and TSH in all groups. However, the TRH-induced increase in the fT4 level in the C18+TRH group was lower than in C5+TRH, and in the OB18+TRH group it was lower than in C18+TRH. In the OB18+TRH group, a tendency towards a decrease in the TRH-induced increase in fT3 was also shown. At the same time, the stimulating effect of TPY3m on TH levels in all studied groups of animals was characterized by stability and did not depend on diet and age. This indicates that the magnitude of the stimulatory effects of TPY3m on TH levels and TSH receptor sensitivity in rats is maintained with age and obesity, suggesting that TPY3m may be useful for developing drugs to compensate for TH deficiency in aging and metabolic disorders.<\/jats:p>","DOI":"10.34922\/ae.2025.38.5.019","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:56:21Z","timestamp":1770620181000},"page":"785-792","source":"Crossref","is-referenced-by-count":0,"title":["\u0421\u041e\u0425\u0420\u0410\u041d\u0415\u041d\u0418\u0415 \u0421\u0422\u0418\u041c\u0423\u041b\u0418\u0420\u0423\u042e\u0429\u0415\u0413\u041e \u042d\u0424\u0424\u0415\u041a\u0422\u0410 \u0410\u041b\u041b\u041e\u0421\u0422\u0415\u0420\u0418\u0427\u0415\u0421\u041a\u041e\u0413\u041e \u0410\u0413\u041e\u041d\u0418\u0421\u0422\u0410 \u0420\u0415\u0426\u0415\u041f\u0422\u041e\u0420\u0410 \u0422\u0418\u0420\u0415\u041e\u0422\u0420\u041e\u041f\u0418\u041d\u0410 \u041d\u0410 \u0423\u0420\u041e\u0412\u0415\u041d\u042c \u0422\u0418\u0420\u0415\u041e\u0418\u0414\u041d\u042b\u0425 \u0413\u041e\u0420\u041c\u041e\u041d\u041e\u0412 \u0423 \u0421\u0422\u0410\u0420\u0415\u042e\u0429\u0418\u0425 \u041a\u0420\u042b\u0421 \u0421 \u041e\u0416\u0418\u0420\u0415\u041d\u0418\u0415\u041c"],"prefix":"10.34922","volume":"38","author":[{"given":"\u041a.\u0412.","family":"\u0414\u0435\u0440\u043a\u0430\u0447","sequence":"first","affiliation":[{"name":"\u0418\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u044d\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u0444\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0431\u0438\u043e\u0445\u0438\u043c\u0438\u0438 \u0438\u043c. \u0418.\u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430 \u0420\u0410\u041d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0418.\u0420.","family":"\u041d\u0430\u0437\u0430\u0440\u043e\u0432","sequence":"first","affiliation":[{"name":"\u0418\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u044d\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u0444\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0431\u0438\u043e\u0445\u0438\u043c\u0438\u0438 \u0438\u043c. \u0418.\u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430 \u0420\u0410\u041d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0418.\u0418.","family":"\u0417\u043e\u0440\u0438\u043d\u0430","sequence":"first","affiliation":[{"name":"\u0418\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u044d\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u0444\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0431\u0438\u043e\u0445\u0438\u043c\u0438\u0438 \u0438\u043c. \u0418.\u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430 \u0420\u0410\u041d"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0410.\u041e.","family":"\u0428\u043f\u0430\u043a\u043e\u0432","sequence":"first","affiliation":[{"name":"\u0418\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u044d\u0432\u043e\u043b\u044e\u0446\u0438\u043e\u043d\u043d\u043e\u0439 \u0444\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u0431\u0438\u043e\u0445\u0438\u043c\u0438\u0438 \u0438\u043c. \u0418.\u041c. \u0421\u0435\u0447\u0435\u043d\u043e\u0432\u0430 \u0420\u0410\u041d"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31754","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"\u0414\u0435\u0440\u043a\u0430\u0447 \u041a.\u0412., \u0411\u043e\u043d\u0434\u0430\u0440\u0435\u0432\u0430 \u0412.\u041c., \u0428\u043f\u0430\u043a\u043e\u0432 \u0410.\u041e. \u041e\u0433\u0440\u0430\u043d\u0438\u0447\u0435\u043d\u0438\u0435 \u0433\u0440\u0443\u0434\u043d\u043e\u0433\u043e \u0432\u0441\u043a\u0430\u0440\u043c\u043b\u0438\u0432\u0430\u043d\u0438\u044f \u0432 \u0440\u0430\u043d\u043d\u0435\u043c \u043f\u043e\u0441\u0442\u043d\u0430\u0442\u0430\u043b\u044c\u043d\u043e\u043c \u043f\u0435\u0440\u0438\u043e\u0434\u0435 \u043f\u0440\u0438\u0432\u043e\u0434\u0438\u0442 \u043a \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0438 \u044d\u043d\u0434\u043e\u043a\u0440\u0438\u043d\u043d\u044b\u043c \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u0430\u043c \u0443 \u0441\u0442\u0430\u0440\u0435\u044e\u0449\u0438\u0445 \u0441\u0430\u043c\u0446\u043e\u0432 \u043a\u0440\u044b\u0441 \/\/ \u0423\u0441\u043f\u0435\u0445\u0438 \u0433\u0435\u0440\u043e\u043d\u0442\u043e\u043b\u043e\u0433\u0438\u0438. 2022. \u0422. 35, \u2116 4. \u0421. 544\u2013551. https:\/\/doi.org\/10.34922\/AE.2022.35.4.013","DOI":"10.34922\/AE.2022.35.4.013"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Araujo R.L., Andrade B.M., Padr\u00f3n A.S. et al. High-fat diet increases thyrotropin and oxygen consumption without altering circulating 3,5,3\u2019-triiodothyronine (T3) and thyroxine in rats: The role of iodothyronine deiodinases, reverse T3 production, and whole-body fat oxidation \/\/ Endocrinology. 2010. Vol. 151, \u2116 7. P. 3460\u20133469. https:\/\/doi.org\/10.1210\/en.2010-0026","DOI":"10.1210\/en.2010-0026"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Bakhtyukov A.A., Derkach K.V., Fokina E.A. et al. Development of low-molecular-weight allosteric agonist of thyroid-stimulating hormone receptor with thyroidogenic activity \/\/ Dokl. Biochem. Biophys. 2022. Vol. 503, \u2116 1. P. 67\u201370. https:\/\/doi.org\/10.1134\/S1607672922020016","DOI":"10.1134\/S1607672922020016"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Bambini F., Gatta E., D\u2019Alessio R. et al. Thyroid disease and autoimmunity in obese patients: A narrative review \/\/ Endokrynologia Polska. 2023. Vol. 74, \u2116 6. https:\/\/pubmed.ncbi.nlm.nih.gov\/37994585","DOI":"10.5603\/ep.96255"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Bruno R., Ferretti E., Tosi E. et al. Modulation of thyroid-specific gene expression in normal and nodular human thyroid tissues from adults: An in vivo effect of thyrotropin \/\/ J. Clin. Endocrinol. Metab. 2005. Vol. 90, \u2116 10. P. 5692\u20135697. https:\/\/doi.org\/10.1210\/jc.2005-0800","DOI":"10.1210\/jc.2005-0800"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Da Costa V.M., Rosenthal D. Effects of aging on thyroidal function and proliferation \/\/ Curr. Aging Sci. 2008. Vol. 1, \u2116 2. P. 101\u2013104. https:\/\/doi.org\/10.2174\/1874609810801020101","DOI":"10.2174\/1874609810801020101"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Derkach K.V., Pechalnova A.S., Sorokoumov V.N. et al. Effect of a low-molecular-weight allosteric agonist of the thyroid-stimulating hormone receptor on basal and thyroliberin-stimulated activity of thyroid system in diabetic rats \/\/ Int. J. Mol. Sci. 2025. Vol. 26, \u2116 2. P. 703. https:\/\/doi.org\/10.3390\/ijms26020703","DOI":"10.3390\/ijms26020703"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Derkach K.V., Sorokoumov V.N., Morina I.Y. et al. Regulatory effects of 5-day oral and intraperitoneal administration of a thienopyrimidine derivative on the thyroid status in rats \/\/ Bull. Exp. Biol. Med. 2024. Vol. 177, \u2116 4. P. 559\u2013563. https:\/\/doi.org\/10.1007\/s10517-024-06223-8","DOI":"10.1007\/s10517-024-06223-8"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Ding X., Zhu C.Y., Li R. et al. Lower normal free thyroxine is associated with a higher risk of metabolic syndrome: A retrospective cohort on Chinese population \/\/ BMC Endocr. Disord. 2021. Vol. 21, \u2116 1. P. 39. https:\/\/doi.org\/10.1186\/s12902-021-00703-y","DOI":"10.1186\/s12902-021-00703-y"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Dwivedi S.N., Kalaria T., Buch H. Thyroid autoantibodies \/\/ J. Clin. Pathol. 2023. Vol. 76, \u2116 1. P. 19\u201328. https:\/\/doi.org\/10.1136\/jcp-2022-208290","DOI":"10.1136\/jcp-2022-208290"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Feldt-Rasmussen U., Effraimidis G., Klose M. The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions \/\/ Mol. Cell. Endocrinol. 2021. Vol. 525. P. 111173. https:\/\/doi.org\/10.1016\/j.mce.2021.111173","DOI":"10.1016\/j.mce.2021.111173"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Hotta H., Ooka H., Sato A. Changes in basal secretion rates of thyroxine and 3,3\u2019,5-triiodothyronine from the thyroid gland during aging of the rat \/\/ Jpn. J. Physiol. 1991. Vol. 41, \u2116 1. P. 75\u201384. https:\/\/doi.org\/10.2170\/jjphysiol.41.75","DOI":"10.2170\/jjphysiol.41.75"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Karponis D., Ananth S. The role of thyrostimulin and its potential clinical significance \/\/ Endocr. Regul. 2017. Vol. 51, \u2116 2. P. 117\u2013128. https:\/\/doi.org\/10.1515\/enr-2017-0012","DOI":"10.1515\/enr-2017-0012"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Le Moli R., Vella V., Tumino D. et al. Inflammasome activation as a link between obesity and thyroid disorders: Implications for an integrated clinical management \/\/ Front. Endocrinol. (Lausanne). 2022. Vol. 13. P. 959276. https:\/\/doi.org\/10.3389\/fendo.2022.959276","DOI":"10.3389\/fendo.2022.959276"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Lisboa P.C., Concei\u00e7\u00e3o E.P., De Oliveira E., Moura E.G. Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood \/\/ J. Endocrinol. 2015. Vol. 226, \u2116 3. P. 219\u2013226. https:\/\/doi.org\/10.1530\/JOE-15-0237","DOI":"10.1530\/JOE-15-0237"},{"key":"16","doi-asserted-by":"crossref","unstructured":"Liu F., Zhang X. Hypertension and Obesity: Risk factors for thyroid disease \/\/ Front. Endocrinol. (Lausanne). 2022. Vol. 13. P. 939367. https:\/\/doi.org\/10.3389\/fendo.2022.939367","DOI":"10.3389\/fendo.2022.939367"},{"key":"17","unstructured":"Millard W.J., Romano T.M., Layden M.P. et al. Growth hormone secretion in the obese male rat: Modulation by the gonadal and thyroid axes \/\/ Growth Dev. Aging. 1991. Vol. 55, \u2116 2. P. 91\u2013103."},{"key":"18","doi-asserted-by":"crossref","unstructured":"Mityukova T.A., Chudilovskaya E.N., Basalai A.A. Reactivity of the thyroid system to short-term stress in Wistar rats with visceral obesity and restricted social activity \/\/ J. Evol. Biochem. Physiol. 2022. Vol. 58, \u2116 2. P. 465\u2013475. https:\/\/doi.org\/10.1134\/S0022093022020156","DOI":"10.1134\/S0022093022020156"},{"key":"19","doi-asserted-by":"crossref","unstructured":"Nelson H.A., Doyle K., Straseski J.A. TSH receptor antibody test utilization patterns from a national reference laboratory: Trab, tsi, or both? \/\/ J. Clin. Endocrinol. Metab. 2025. dgaf330. https:\/\/doi.org\/10.1210\/clinem\/dgaf330","DOI":"10.1210\/clinem\/dgaf330"},{"key":"20","doi-asserted-by":"crossref","unstructured":"Neto J.G.O., Rom\u00e3o J.S., Pazos-Moura C.C., Oliveira K.J. Fructose consumption induces molecular adaptations involving thyroid function and thyroid-related genes in brown adipose tissue in rats \/\/ Braz. J. Med. Biol. Res. 2023. Vol. 55. e12240. https:\/\/doi.org\/10.1590\/1414-431X2022e12240","DOI":"10.1590\/1414-431x2022e12240"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Newton C.L., Whay A.M., McArdle C.A. et al. Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist \/\/ Proc. Natl. Acad. Sci. USA. 2011. Vol. 108, \u2116 17. P. 7172\u20137176. https:\/\/doi.org\/10.1073\/pnas.1015723108","DOI":"10.1073\/pnas.1015723108"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Ogbonna S.U., Ezeani I.U. Risk factors of thyroid dysfunction in patients with type 2 diabetes mellitus \/\/ Front. Endocrinol. (Lausanne). 2019. Vol. 10. P. 440. https:\/\/doi.org\/10.3389\/fendo.2019.00440","DOI":"10.3389\/fendo.2019.00440"},{"key":"23","doi-asserted-by":"crossref","unstructured":"Pather R., Khathi A., Ngubane P. The effects of obesity on thyroid function in a metabolically healthy high-fat, high-carbohydrate diet-induced obese rat model \/\/ Front. Endocrinol. (Lausanne). 2025. Vol. 16. P. 1538627. https:\/\/doi.org\/10.3389\/fendo.2025.1538627","DOI":"10.3389\/fendo.2025.1538627"},{"key":"24","doi-asserted-by":"crossref","unstructured":"Shao S.S., Zhao Y.F., Song Y.F. et al. Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats \/\/ Acta Pharmacol. Sin. 2014. Vol. 35, \u2116 11. P. 1411\u20131420. https:\/\/doi.org\/10.1038\/aps.2014.82","DOI":"10.1038\/aps.2014.82"},{"key":"25","doi-asserted-by":"crossref","unstructured":"Shpakov A.O. Allosteric regulation of g-protein-coupled receptors: From diversity of molecular mechanisms to multiple allosteric sites and their ligands \/\/ Int. J. Mol. Sci. 2023. Vol. 24, \u2116 7. P. 6187. https:\/\/doi.org\/10.3390\/ijms24076187","DOI":"10.3390\/ijms24076187"},{"key":"26","doi-asserted-by":"crossref","unstructured":"Ulloa-Aguirre A., Zari\u00f1\u00e1n T., Jard\u00f3n-Valadez E. Misfolded G protein-coupled receptors and endocrine disease. Molecular mechanisms and therapeutic prospects \/\/ Int. J. Mol. Sci. 2021. Vol. 22, \u2116 22. P. 12329. https:\/\/doi.org\/10.3390\/ijms222212329","DOI":"10.3390\/ijms222212329"},{"key":"27","doi-asserted-by":"crossref","unstructured":"Veldhuis J.D. Changes in pituitary function with ageing and implications for patient care \/\/ Nat. Rev. Endocrinol. 2013. Vol. 9, \u2116 4. P. 205\u2013215. https:\/\/doi.org\/10.1038\/nrendo.2013.38","DOI":"10.1038\/nrendo.2013.38"},{"key":"28","doi-asserted-by":"crossref","unstructured":"Vieira I.H., Rodrigues D., Paiva I. The Mysterious Universe of the TSH Receptor \/\/ Front. Endocrinol. (Lausanne). 2022. Vol. 13. P. 944715. https:\/\/doi.org\/10.3389\/fendo.2022.944715","DOI":"10.3389\/fendo.2022.944715"},{"key":"29","doi-asserted-by":"crossref","unstructured":"Walczak K., Sieminska L. Obesity and thyroid axis \/\/ Int. J. Environ. Res. Public Health. 2021. Vol. 18, \u2116 18. P. 9434. https:\/\/doi.org\/10.3390\/ijerph18189434","DOI":"10.3390\/ijerph18189434"},{"key":"30","doi-asserted-by":"crossref","unstructured":"Zhang Y., Tan Y., Zhang Z. et al. Targeting thyroid-stimulating hormone receptor: A perspective on small-molecule modulators and their therapeutic potential \/\/ J. Med. Chem. 2024. Vol. 67, \u2116 18. P. 16018\u201316034. https:\/\/doi.org\/10.1021\/acs.jmedchem.4c01525","DOI":"10.1021\/acs.jmedchem.4c01525"}],"container-title":["\u0423\u0441\u043f\u0435\u0445\u0438 \u0433\u0435\u0440\u043e\u043d\u0442\u043e\u043b\u043e\u0433\u0438\u0438"],"original-title":[],"language":"ru","deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:58:10Z","timestamp":1770620290000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.gersociety.ru\/netcat_files\/userfiles\/10\/AG_2025-38-05.pdf#page=157"}},"subtitle":["PRESERVATION OF THE STIMULATORY EFFECT OF THYROID STIMULATING HORMONE RECEPTOR ALLOSTERIC AGONIST ON THYROID HORMONE LEVEL IN AGING RATS WITH OBESITY"],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,2,2]]}},"URL":"https:\/\/doi.org\/10.34922\/ae.2025.38.5.019","relation":{},"ISSN":["1561-9125"],"issn-type":[{"value":"1561-9125","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}