{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:42:54Z","timestamp":1789087374077,"version":"build-2803163510"},"reference-count":13,"publisher":"Saint Petersburg Institute of Bioregulation and Gerontology","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:p>\u041d\u0435\u0439\u0442\u0440\u043e\u0444\u0438\u043b\u044c\u043d\u043e-\u043b\u0438\u043c\u0444\u043e\u0446\u0438\u0442\u0430\u0440\u043d\u043e\u0435 \u0441\u043e\u043e\u0442\u043d\u043e\u0448\u0435\u043d\u0438\u0435 (NLR) \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u043f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u044b\u043c \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0433\u043e \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u044f \u0438 \u0441\u0442\u0440\u0435\u0441\u0441\u0430 \u0434\u043b\u044f \u0441\u0442\u0440\u0430\u0442\u0438\u0444\u0438\u043a\u0430\u0446\u0438\u0438 \u0440\u0438\u0441\u043a\u0430 \u043f\u0440\u0438 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f\u0445. \u041e\u0434\u043d\u0430\u043a\u043e \u0435\u0433\u043e \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0437\u043d\u0430\u0447\u0438\u043c\u043e\u0441\u0442\u044c \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0440\u0430\u0437\u043d\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u0438 \u043f\u043e\u043b\u0430 \u0441 \u043e\u0441\u0442\u0440\u044b\u043c\u0438 \u0444\u043e\u0440\u043c\u0430\u043c\u0438 \u0418\u0411\u0421 \u0438\u0437\u0443\u0447\u0435\u043d\u0430 \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e. \u0412 \u0445\u043e\u0434\u0435 \u0440\u0435\u0442\u0440\u043e\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u0430\u043d\u0430\u043b\u0438\u0437\u0430 \u0434\u0430\u043d\u043d\u044b\u0445 757 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0418\u0411\u0421 \u0431\u044b\u043b\u0430 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0430 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0437\u043d\u0430\u0447\u0438\u043c\u043e\u0441\u0442\u044c NLR \u0441 \u0443\u0447\u0435\u0442\u043e\u043c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043d\u044b\u0445 \u0438 \u043f\u043e\u043b\u043e\u0432\u044b\u0445 \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0435\u0439. \u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u0434\u0435\u043c\u043e\u043d\u0441\u0442\u0440\u0438\u0440\u0443\u044e\u0442 \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u043d\u0443\u044e \u0437\u0430\u0432\u0438\u0441\u0438\u043c\u043e\u0441\u0442\u044c \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0446\u0435\u043d\u043d\u043e\u0441\u0442\u0438 NLR \u043e\u0442 \u0434\u0435\u043c\u043e\u0433\u0440\u0430\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0444\u0430\u043a\u0442\u043e\u0440\u043e\u0432. \u041d\u0430\u0438\u0431\u043e\u043b\u044c\u0448\u0430\u044f \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044f \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0430 \u0443 \u043c\u0443\u0436\u0447\u0438\u043d \u0441\u0440\u0435\u0434\u043d\u0435\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 (45\u201359 \u043b\u0435\u0442) \u0434\u043b\u044f \u0434\u0438\u0444\u0444\u0435\u0440\u0435\u043d\u0446\u0438\u0430\u0446\u0438\u0438 \u043e\u0441\u0442\u0440\u043e\u0433\u043e \u043a\u043e\u0440\u043e\u043d\u0430\u0440\u043d\u043e\u0433\u043e \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0430 \u0441 \u043f\u043e\u0434\u044a\u0451\u043c\u043e\u043c \u0441\u0435\u0433\u043c\u0435\u043d\u0442\u0430 ST \u043e\u0442 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0439 \u0441\u0442\u0435\u043d\u043e\u043a\u0430\u0440\u0434\u0438\u0438 (AUC=0,81). \u0421 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043e\u043c \u0434\u0438\u0441\u043a\u0440\u0438\u043c\u0438\u043d\u0430\u0446\u0438\u043e\u043d\u043d\u0430\u044f \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c NLR \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0432\u043d\u043e \u0441\u043d\u0438\u0436\u0430\u043b\u0430\u0441\u044c. \u0423 \u0436\u0435\u043d\u0449\u0438\u043d \u0441\u0440\u0435\u0434\u043d\u0435\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u0437\u043d\u0430\u0447\u0438\u043c\u044b\u0435 \u0440\u0430\u0437\u043b\u0438\u0447\u0438\u044f \u0432 NLR \u043c\u0435\u0436\u0434\u0443 \u0444\u043e\u0440\u043c\u0430\u043c\u0438 \u0418\u0411\u0421 \u043e\u0442\u0441\u0443\u0442\u0441\u0442\u0432\u043e\u0432\u0430\u043b\u0438, \u0442\u043e\u0433\u0434\u0430 \u043a\u0430\u043a \u0432 \u043f\u043e\u0436\u0438\u043b\u043e\u043c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 (60\u201374 \u0433\u043e\u0434\u0430) \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0437\u043d\u0430\u0447\u0438\u043c\u043e\u0441\u0442\u044c NLR \u043f\u043e\u0432\u044b\u0448\u0430\u043b\u0430\u0441\u044c \u0441 \u0432\u044b\u044f\u0432\u043b\u0435\u043d\u0438\u0435\u043c \u0432\u044b\u0441\u043e\u043a\u0438\u0445 \u043f\u043e\u0440\u043e\u0433\u043e\u0432\u044b\u0445 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0439 (&gt;5,935). \u041f\u043e\u043b\u0443\u0447\u0435\u043d\u043d\u044b\u0435 \u0434\u0430\u043d\u043d\u044b\u0435 \u0441\u0432\u0438\u0434\u0435\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u0443\u044e\u0442 \u043e \u043d\u0435\u043e\u0431\u0445\u043e\u0434\u0438\u043c\u043e\u0441\u0442\u0438 \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u043a\u0438 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u043d\u044b\u0445 \u0434\u043b\u044f \u043f\u043e\u043b\u0430 \u0438 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u0440\u0435\u0444\u0435\u0440\u0435\u043d\u0441\u043d\u044b\u0445 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0439 NLR \u0434\u043b\u044f \u043e\u043f\u0442\u0438\u043c\u0438\u0437\u0430\u0446\u0438\u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \u0418\u0411\u0421.<\/jats:p>\n                  <jats:p>The neutrophil-to-lymphocyte ratio (NLR) is a promising biomarker of systemic inflammation and stress for risk stratification in cardiovascular disease. However, its diagnostic value in patients of different ages and genders with coronary heart disease (CHD) has been poorly studied. A retrospective analysis of 757 patients with coronary artery disease was conducted to examine the diagnostic value of NLR, taking into account age and gender characteristics. The results demonstrate a significant correlation between the diagnostic value of NLR and demographic factors. The indicator was most effective in differentiating ST-segment elevation acute coronary syndrome from stable angina in middle-aged men (45\u201359 years) (AUC=0.81). The discriminatory ability of NLR progressively decreased with age. In middle-aged women, there were no significant differences in NLR between CHD forms, whereas in older women (60\u201374 years), the diagnostic significance of NLR increased with the detection of high threshold values (&gt;5.935). These data indicate the need to develop age- and sex-specific NLR reference values to optimize CHD diagnostics.<\/jats:p>","DOI":"10.34922\/ae.2025.38.6.003","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:48:08Z","timestamp":1784112488000},"page":"817-822","source":"Crossref","is-referenced-by-count":1,"title":["\u041d\u0415\u0419\u0422\u0420\u041e\u0424\u0418\u041b\u042c\u041d\u041e-\u041b\u0418\u041c\u0424\u041e\u0426\u0418\u0422\u0410\u0420\u041d\u041e\u0415 \u0421\u041e\u041e\u0422\u041d\u041e\u0428\u0415\u041d\u0418\u0415 \u0423 \u041f\u0410\u0426\u0418\u0415\u041d\u0422\u041e\u0412 \u0421\u0422\u0410\u0420\u0428\u0418\u0425 \u0412\u041e\u0417\u0420\u0410\u0421\u0422\u041d\u042b\u0425 \u0413\u0420\u0423\u041f\u041f \u0421 \u041e\u0421\u0422\u0420\u042b\u041c\u0418 \u0424\u041e\u0420\u041c\u0410\u041c\u0418 \u0418\u0428\u0415\u041c\u0418\u0427\u0415\u0421\u041a\u041e\u0419 \u0411\u041e\u041b\u0415\u0417\u041d\u0418 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