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This problem is associated with age-related changes in physiology and anatomical features of the nasal structures and paranasal sinuses. The article substantiates the need to study the manifestations of endothelial dysfunction as a link in the pathogenesis of the development of chronic pathology. The article provides an example of developing a diagnostic algorithm using modern technologies in the form of a computer program. The study involved 109 people aged 60\u201372 with chronic polyposis rhinosinusitis and without this pathology (comparison group). D-dimer, cystatin C, high-sensitivity C-reactive protein, and homocysteine were selected as markers of endothelial dysfunction. Based on these markers, a diagnostic mathematical model and computer program were developed.<\/jats:p>","DOI":"10.34922\/ae.2025.38.6.011","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T10:48:08Z","timestamp":1784112488000},"page":"881-886","source":"Crossref","is-referenced-by-count":0,"title":["\u0414\u0418\u0410\u0413\u041d\u041e\u0421\u0422\u0418\u0427\u0415\u0421\u041a\u0418\u0419 \u0410\u041b\u0413\u041e\u0420\u0418\u0422\u041c \u041f\u0420\u0418 \u0425\u0420\u041e\u041d\u0418\u0427\u0415\u0421\u041a\u041e\u041c \u041f\u041e\u041b\u0418\u041f\u041e\u0417\u041d\u041e\u041c \u0420\u0418\u041d\u041e\u0421\u0418\u041d\u0423\u0421\u0418\u0422\u0415 \u0423 \u041f\u0410\u0426\u0418\u0415\u041d\u0422\u041e\u0412 \u041f\u041e\u0416\u0418\u041b\u041e\u0413\u041e 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\u0413\u0443\u0440\u043e\u0432 \u0410.\u0412., \u0424\u043e\u043c\u0438\u043d\u0430 \u0414.\u0421. \u0438 \u0434\u0440. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0439 \u0432\u0437\u0433\u043b\u044f\u0434 \u043d\u0430 \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0443 \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0440\u0435\u0446\u0438\u0434\u0438\u0432\u0438\u0440\u0443\u044e\u0449\u0435\u0433\u043e \u043f\u043e\u043b\u0438\u043f\u043e\u0437\u043d\u043e\u0433\u043e \u0440\u0438\u043d\u043e\u0441\u0438\u043d\u0443\u0441\u0438\u0442\u0430, \u0441\u0440\u0430\u0432\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0438 \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0440\u0430\u0437\u043b\u0438\u0447\u043d\u044b\u0445 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u0432 \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b \/\/ \u041c\u0435\u0434. \u0441\u043e\u0432\u0435\u0442. 2024. \u2116 18 (23). \u0421. 80\u201386. https:\/\/doi.org\/10.21518\/ms2024-510","DOI":"10.21518\/ms2024-510"},{"key":"6","doi-asserted-by":"crossref","unstructured":"\u041b\u043e\u043f\u0430\u0442\u0438\u043d \u0410.\u0421., \u0410\u0437\u0438\u0437\u043e\u0432 \u0418.\u0421., \u041a\u043e\u0437\u043b\u043e\u0432 \u0420.\u0421. \u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043c \u043f\u043e\u043b\u043e\u0441\u0442\u0438 \u043d\u043e\u0441\u0430 \u0438 \u043e\u043a\u043e\u043b\u043e\u043d\u043e\u0441\u043e\u0432\u044b\u0445 \u043f\u0430\u0437\u0443\u0445 \u0432 \u043d\u043e\u0440\u043c\u0435 \u0438 \u043f\u0440\u0438 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438. \u0427\u0430\u0441\u0442\u044c I \/\/ \u0420\u043e\u0441. \u0440\u0438\u043d\u043e\u043b. 2021. \u2116 29 (1). \u0421. 23\u201330. https:\/\/doi.org\/10.17116\/rosrino20212901123","DOI":"10.17116\/rosrino20212901123"},{"key":"7","doi-asserted-by":"crossref","unstructured":"\u041b\u043e\u043f\u0430\u0442\u0438\u043d \u0410.\u0421., \u0428\u0438\u043b\u0435\u043d\u043a\u043e\u0432\u0430 \u0412.\u0412., \u0413\u0443\u0440\u043e\u0432 \u0410.\u0412. \u0438 \u0434\u0440. \u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0440\u0438\u043d\u043e\u0441\u0438\u043d\u0443\u0441\u0438\u0442: \u043f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438 \/\/ \u0424\u0430\u0440\u043c\u0430\u043a\u043e\u043b. \u0438 \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440. \u0421\u043f\u0435\u0446\u0432\u044b\u043f\u0443\u0441\u043a. 2024. \u0421. 54\u201368. https:\/\/doi.org\/10.46393\/27132129_2024_1_56","DOI":"10.46393\/27132129_2024_1_56"},{"key":"8","unstructured":"\u041c\u0430\u043c\u0430\u0435\u0432 \u0410.\u041d., \u041a\u0443\u0434\u043b\u0430\u0439 \u0414.\u0410. \u0421\u0442\u0430\u0442\u0438\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u0432 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0435. \u041c.: \u041f\u0440\u0430\u043a\u0442\u0438\u0447. \u043c\u0435\u0434., 2021."},{"key":"9","unstructured":"\u041c\u0443\u0440\u043a\u0430\u043c\u0438\u043b\u043e\u0432 \u0418.\u0422. \u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u043e\u0447\u0435\u043a \u0443 \u043b\u0438\u0446 \u043f\u043e\u0436\u0438\u043b\u043e\u0433\u043e \u0438 \u0441\u0442\u0430\u0440\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430: \u0444\u0430\u043a\u0442\u043e\u0440\u044b \u0440\u0438\u0441\u043a\u0430 \u0438 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0440\u0430\u043d\u043d\u0435\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \/\/ \u041b\u0435\u0447. \u0434\u0435\u043b\u043e. 2019. \u2116 4. \u0421. 108\u2013114. https:\/\/doi.org\/10.24411\/2071-5315-2019-12164"},{"key":"10","doi-asserted-by":"crossref","unstructured":"\u041e\u043f\u043e\u043b\u043e\u0432\u043d\u0438\u043a\u043e\u0432\u0430 \u041a., \u0425\u0430\u0440\u0438\u0431\u043e\u0432\u0430 \u0415. \u0421\u0440\u0430\u0432\u043d\u0438\u0442\u0435\u043b\u044c\u043d\u0430\u044f \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043d\u0430\u044f \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430 \u043e\u043a\u043e\u043b\u043e\u043d\u043e\u0441\u043e\u0432\u044b\u0445 \u043f\u0430\u0437\u0443\u0445 \u0432 \u043f\u043e\u0441\u0442\u043d\u0430\u0442\u0430\u043b\u044c\u043d\u043e\u043c \u043e\u043d\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0435 (\u043e\u0431\u0437\u043e\u0440 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u044b) \/\/ \u041e\u0431\u0449\u0435\u0441\u0442\u0432\u043e \u0438 \u0438\u043d\u043d\u043e\u0432\u0430\u0446\u0438\u0438 \u2014 Society and Innovations. Special Iss. 2021. \u0422. 12, \u2116 6. \u0421. 1\u20138.","DOI":"10.47689\/2181-1415-vol2-iss6\/S-pp1-8"},{"key":"11","doi-asserted-by":"crossref","unstructured":"\u041f\u0430\u0439\u0433\u0430\u043d\u043e\u0432\u0430 \u041d.\u042d., \u042f\u0441\u0442\u0440\u0435\u043c\u0441\u043a\u0438\u0439 \u0410.\u041f. \u0421\u043b\u0438\u0437\u0438\u0441\u0442\u0430\u044f \u043e\u0431\u043e\u043b\u043e\u0447\u043a\u0430 \u043f\u043e\u043b\u043e\u0441\u0442\u0438 \u043d\u043e\u0441\u0430 \u0432 \u043f\u043e\u0436\u0438\u043b\u043e\u043c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435: \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438, \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043f\u043e\u0434\u0445\u043e\u0434\u044b \u043a \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u043f\u043e\u043b\u043e\u0441\u0442\u0438 \u043d\u043e\u0441\u0430 \u0438 \u043e\u043a\u043e\u043b\u043e\u043d\u043e\u0441\u043e\u0432\u044b\u0445 \u043f\u0430\u0437\u0443\u0445 \/\/ \u0412\u0435\u0441\u0442\u043d. \u043e\u0442\u043e\u0440\u0438\u043d\u043e\u043b\u0430\u0440\u0438\u043d\u0433\u043e\u043b. 2021. \u2116 86 (5). \u0421. 103\u2013108. https:\/\/doi.org\/10.17116\/otorino202186051103","DOI":"10.17116\/otorino202186051103"},{"key":"12","doi-asserted-by":"crossref","unstructured":"\u041f\u0430\u0439\u0433\u0430\u043d\u043e\u0432\u0430 \u041d.\u042d., \u042f\u0441\u0442\u0440\u0435\u043c\u0441\u043a\u0438\u0439 \u0410.\u041f. \u041f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u044b \u043f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u044f \u0430\u043d\u0442\u0438\u043c\u0438\u043a\u0440\u043e\u0431\u043d\u044b\u0445 \u043f\u0435\u043f\u0442\u0438\u0434\u043e\u0432 \u0432 \u043e\u0442\u043e\u0440\u0438\u043d\u043e\u043b\u0430\u0440\u0438\u043d\u0433\u043e\u043b\u043e\u0433\u0438\u0438 \u0432 \u0443\u0441\u043b\u043e\u0432\u0438\u044f\u0445 \u0440\u0430\u0441\u0442\u0443\u0449\u0435\u0439 \u0430\u043d\u0442\u0438\u0431\u0438\u043e\u0442\u0438\u043a\u043e\u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u0438 \/\/ \u0412\u0435\u0441\u0442\u043d. \u043e\u0442\u043e\u0440\u0438\u043d\u043e\u043b\u0430\u0440\u0438\u043d\u0433\u043e\u043b. 2021. \u2116 86 (3). \u0421. 104\u2013109. https:\/\/doi.org\/10.17116\/otorino202186031104","DOI":"10.17116\/otorino202186031104"},{"key":"13","unstructured":"\u041f\u0438\u0441\u043a\u0443\u043d\u043e\u0432 \u0413.\u0417., \u041c\u043e\u0438\u0441\u0435\u0435\u0432\u0430 \u042e.\u041f. \u041f\u043e\u043b\u0438\u043f\u043e\u0437\u043d\u044b\u0439 \u0440\u0438\u043d\u043e\u0441\u0438\u043d\u0443\u0441\u0438\u0442 (2-\u0435 \u0438\u0437\u0434., \u0434\u043e\u043f.). \u041c.: \u041c\u0415\u0414\u043f\u0440\u0435\u0441\u0441-\u0438\u043d\u0444\u043e\u0440\u043c, 2021."},{"key":"14","doi-asserted-by":"crossref","unstructured":"\u0421\u0435\u0440\u043e\u0432\u0430 \u041d.\u0421., \u0413\u0440\u0438\u0434\u0430\u0441\u043e\u0432\u0430 \u0418.\u0421., \u041c\u0438\u0445\u0430\u0439\u043b\u0438\u043d \u0421.\u0414. \u0438 \u0434\u0440. \u041b\u0443\u0447\u0435\u0432\u0430\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u043e\u0434\u043e\u043d\u0442\u043e\u0433\u0435\u043d\u043d\u043e\u0433\u043e \u0432\u0435\u0440\u0445\u043d\u0435\u0447\u0435\u043b\u044e\u0441\u0442\u043d\u043e\u0433\u043e \u0441\u0438\u043d\u0443\u0441\u0438\u0442\u0430 \/\/ Rus. Electronic J. Radiol. 2023. \u2116 13 (2). \u0421. 109\u2013127. https:\/\/doi.org\/10.21569\/2222-7415-2023-13-2-109-127","DOI":"10.21569\/2222-7415-2023-13-2-109-127"},{"key":"15","doi-asserted-by":"crossref","unstructured":"\u0422\u0430\u0440\u0430\u0441\u043e\u0432\u0430 \u041d.\u0412., \u0411\u0435\u043b\u0430\u043d \u042d.\u0411., \u0421\u043e\u043a\u043e\u043b\u043e\u0432\u0430 \u041c.\u0412., \u0413\u043e\u0440\u0448\u0435\u043d\u0438\u043d \u0410.\u0412. \u0421\u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 \u0438\u043d\u0442\u0435\u0440\u043b\u0435\u0439\u043a\u0438\u043d\u043e\u0432 4, 6, 8, 10 \u0432 \u043d\u0430\u0437\u0430\u043b\u044c\u043d\u043e\u043c \u0441\u043c\u044b\u0432\u0435 \u043f\u0440\u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u043c \u0440\u0438\u043d\u043e\u0441\u0438\u043d\u0443\u0441\u0438\u0442\u0435 \u0443 \u043b\u0438\u0446 \u043f\u043e\u0436\u0438\u043b\u043e\u0433\u043e \u0438 \u0441\u0442\u0430\u0440\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \/\/ \u0410\u0441\u043f\u0438\u0440\u0430\u043d\u0442\u0441\u043a\u0438\u0439 \u0432\u0435\u0441\u0442\u043d. \u041f\u043e\u0432\u043e\u043b\u0436\u044c\u044f. 2024. \u2116 24 (1). \u0421. 20\u201324. https:\/\/doi.org\/10.35693\/AVP568785","DOI":"10.35693\/AVP568785"},{"key":"16","doi-asserted-by":"crossref","unstructured":"\u0422\u0430\u0440\u0430\u0441\u043e\u0432\u0430 \u041d.\u0412., \u0411\u0435\u043b\u0430\u043d \u042d.\u0411., \u0421\u0442\u0435\u043f\u0430\u043d\u0435\u043d\u043a\u043e \u0418.\u0421., \u0421\u043e\u043a\u043e\u043b\u043e\u0432\u0430 \u041c.\u0412. \u041c\u0438\u043a\u0440\u043e\u0431\u043d\u0430\u044f \u043a\u043e\u043b\u043e\u043d\u0438\u0437\u0430\u0446\u0438\u044f \u0441\u043b\u0438\u0437\u0438\u0441\u0442\u043e\u0439 \u043e\u0431\u043e\u043b\u043e\u0447\u043a\u0438 \u043f\u043e\u043b\u043e\u0441\u0442\u0438 \u043d\u043e\u0441\u0430 \u0443 \u043f\u043e\u0436\u0438\u043b\u044b\u0445 \u043b\u044e\u0434\u0435\u0439 \u0441 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0440\u0438\u043d\u043e\u0441\u0438\u043d\u0443\u0441\u0438\u0442\u043e\u043c \/\/ \u0421\u0430\u0440\u0430\u0442\u043e\u0432\u0441\u043a\u0438\u0439 \u043d\u0430\u0443\u0447.-\u043c\u0435\u0434. \u0436\u0443\u0440\u043d. 2024. \u2116 20 (2). \u0421. 121\u2013126. https:\/\/doi.org\/10.15275\/ssmj2002121","DOI":"10.15275\/ssmj2002121"},{"key":"17","doi-asserted-by":"crossref","unstructured":"\u0428\u0430\u043c\u043a\u0438\u043d\u0430 \u041f.\u0410., \u041a\u0440\u0438\u0432\u043e\u043f\u0430\u043b\u043e\u0432 \u0410.\u0410., \u0420\u044f\u0437\u0430\u043d\u0446\u0435\u0432 \u0421.\u0412. \u0438 \u0434\u0440. \u042d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0440\u0438\u043d\u043e\u0441\u0438\u043d\u0443\u0441\u0438\u0442\u043e\u0432 \/\/ \u0421\u043e\u0432\u0440\u0435\u043c. \u043f\u0440\u043e\u0431\u043b. \u043d\u0430\u0443\u043a\u0438 \u0438 \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f. 2019. \u2116 3. \u0421. 188. https:\/\/doi.org\/10.17513\/spno.28891","DOI":"10.17513\/spno.28891"},{"key":"18","doi-asserted-by":"crossref","unstructured":"\u0428\u0438\u0445 \u0415.\u0412., \u0420\u0435\u0431\u0440\u043e\u0432\u0430 \u0415.\u0412. \u042d\u043d\u0434\u043e\u0442\u0435\u043b\u0438\u0430\u043b\u044c\u043d\u0430\u044f \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u044f \u0438 \u0440\u0435\u0433\u0443\u043b\u044f\u0442\u043e\u0440\u043d\u044b\u0435 \u043f\u0435\u043f\u0442\u0438\u0434\u044b \/\/ \u041a\u0430\u0440\u0434\u0438\u043e\u043b. \u0438 \u0441\u0435\u0440\u0434\u0435\u0447.-\u0441\u043e\u0441\u0443\u0434. \u0445\u0438\u0440. 2023. \u2116 16 (2). \u0421. 205\u2013210. https:\/\/doi.org\/10.17116\/kardio202316021205","DOI":"10.17116\/kardio202316021205"},{"key":"19","unstructured":"\u042e\u043f\u0430\u0442\u043e\u0432 \u0415.\u042e., \u041a\u0443\u0440\u043c\u0430\u043d\u0431\u0430\u0435\u0432 \u0422.\u0415., \u0422\u0438\u043c\u043e\u0448\u043a\u043e\u0432\u0430 \u042e.\u041b. \u0421\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u043e\u0435 \u043f\u043e\u043d\u0438\u043c\u0430\u043d\u0438\u0435 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u0438 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u044d\u043d\u0434\u043e\u0442\u0435\u043b\u0438\u044f \u0441\u043e\u0441\u0443\u0434\u043e\u0432: \u043e\u0431\u0437\u043e\u0440 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u044b \/\/ \u0420\u043e\u0441. \u043c\u0435\u0434. \u0436\u0443\u0440\u043d. 2022. \u2116 3. \u0421. 20\u201323."},{"key":"20","doi-asserted-by":"crossref","unstructured":"Fokkens W.J., Lund V.J., Hopkins C. et al. European position paper on rhinosinusitis and nasal polyps 2020 \/\/ Rhinology. 2020. \u2116 58 (Suppl. 29). \u0420. 1\u2013464. https:\/\/doi.org\/10.4193\/Rhin20.600","DOI":"10.4193\/Rhin20.600"},{"key":"21","doi-asserted-by":"crossref","unstructured":"Khan A., Vandeplas G., Huynh T.M.T. et al. The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort: A large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps \/\/ Rhinology. 2019. \u2116 57 (1). \u0420. 32\u201342. https:\/\/doi.org\/10.4193\/Rhin17.255","DOI":"10.4193\/Rhin17.255"},{"key":"22","doi-asserted-by":"crossref","unstructured":"Sudiro M., Kuntara A., Waldi D. Correlation of lund-mackay score on computed tomography scan and nasoendoscopic score in chronic rhinosinusitis \/\/ Acta Inform. Med. 2023. Vol. 31 (1). 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