{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:56:31Z","timestamp":1785704191963,"version":"3.56.0"},"reference-count":25,"publisher":"Saint Petersburg Institute of Bioregulation and Gerontology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:p>\u041f\u043e\u0438\u0441\u043a \u0434\u043e\u0441\u0442\u0443\u043f\u043d\u044b\u0445 \u0438 \u043d\u0435\u0438\u043d\u0432\u0430\u0437\u0438\u0432\u043d\u044b\u0445 \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u0432 \u0434\u043b\u044f \u043e\u0446\u0435\u043d\u043a\u0438 \u0442\u0435\u043c\u043f\u043e\u0432 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u043e\u0433\u043e \u0441\u0442\u0430\u0440\u0435\u043d\u0438\u044f \u2014 \u043f\u0440\u0438\u043e\u0440\u0438\u0442\u0435\u0442\u043d\u0430\u044f \u0437\u0430\u0434\u0430\u0447\u0430 \u0433\u0435\u0440\u043e\u043d\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043f\u0435\u0440\u0441\u043e\u043d\u0430\u043b\u0438\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u044b. \u0426\u0435\u043b\u044c \u0440\u0430\u0431\u043e\u0442\u044b \u2014 \u043e\u0446\u0435\u043d\u043a\u0430 \u0441\u0432\u044f\u0437\u0438 \u043c\u043e\u0440\u0444\u043e\u043c\u0435\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0430\u0440\u0430\u043c\u0435\u0442\u0440\u043e\u0432 \u0441\u0435\u0442\u0447\u0430\u0442\u043a\u0438 \u0438 \u0445\u043e\u0440\u0438\u043e\u0438\u0434\u0435\u0438 \u0441 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043e\u043c \u0443 \u0437\u0434\u043e\u0440\u043e\u0432\u044b\u0445 \u043b\u0438\u0446. \u0412 \u0440\u0430\u043c\u043a\u0430\u0445 \u043f\u0440\u043e\u0435\u043a\u0442\u0430 RussAge \u0431\u044b\u043b\u0438 \u043e\u0431\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u044b 148 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438 \u0437\u0434\u043e\u0440\u043e\u0432\u044b\u0445 \u0434\u043e\u0431\u0440\u043e\u0432\u043e\u043b\u044c\u0446\u0435\u0432 22\u201374 \u043b\u0435\u0442 (296 \u0433\u043b\u0430\u0437). \u0411\u044b\u043b\u0430 \u0432\u044b\u043f\u043e\u043b\u043d\u0435\u043d\u0430 \u043e\u043f\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043a\u043e\u0433\u0435\u0440\u0435\u043d\u0442\u043d\u0430\u044f \u0442\u043e\u043c\u043e\u0433\u0440\u0430\u0444\u0438\u044f (\u041e\u041a\u0422) \u043c\u0430\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0439 \u0437\u043e\u043d\u044b (Topcon Triton) \u0438 \u0440\u0430\u0441\u0441\u0447\u0438\u0442\u0430\u043d \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0432\u043e\u0437\u0440\u0430\u0441\u0442 (PhenoAge). \u041f\u043e\u043a\u0430\u0437\u0430\u043d\u0430 \u0441\u043e\u0433\u043b\u0430\u0441\u043e\u0432\u0430\u043d\u043d\u043e\u0441\u0442\u044c \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043d\u044b\u0445 \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0439 \u0441\u0435\u0442\u0447\u0430\u0442\u043a\u0438 \u0438 \u0445\u043e\u0440\u0438\u043e\u0438\u0434\u0435\u0438 \u0441 \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043e\u043c. \u0414\u043b\u044f \u0431\u043e\u043b\u044c\u0448\u0438\u043d\u0441\u0442\u0432\u0430 \u043f\u0430\u0440\u0430\u043c\u0435\u0442\u0440\u043e\u0432 \u0431\u044b\u043b\u0430 \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u043d\u0430 \u0432\u044b\u0441\u043e\u043a\u0430\u044f \u043c\u0435\u0436\u043e\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0441\u0438\u043c\u043c\u0435\u0442\u0440\u0438\u044f. \u0421 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u043e\u043c \u043e\u0442\u043c\u0435\u0447\u0435\u043d\u043e \u0432\u044b\u0440\u0430\u0436\u0435\u043d\u043d\u043e\u0435 \u0438\u0441\u0442\u043e\u043d\u0447\u0435\u043d\u0438\u0435 \u0445\u043e\u0440\u0438\u043e\u0438\u0434\u0435\u0438 (\u0434\u043e ~19%) \u0438 \u0443\u043c\u0435\u0440\u0435\u043d\u043d\u043e\u0435 \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u0442\u043e\u043b\u0449\u0438\u043d\u044b \u0441\u043b\u043e\u044f \u043d\u0435\u0440\u0432\u043d\u044b\u0445 \u0432\u043e\u043b\u043e\u043a\u043e\u043d \u0438 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u0430 IPL+GCL (~5%) \u043f\u0440\u0438 \u043e\u0442\u043d\u043e\u0441\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0441\u0442\u0430\u0431\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u0438 INL \u0438 ONL+PIS. \u041f\u0430\u0442\u0442\u0435\u0440\u043d\u044b \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u0439 \u0431\u044b\u043b\u0438 \u0441\u0445\u043e\u0434\u043d\u044b \u043f\u0440\u0438 \u043c\u043e\u0434\u0435\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0438 \u043f\u043e \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u043c\u0443 \u0438 \u0445\u0440\u043e\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u043c\u0443 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0443. \u041e\u041a\u0422-\u043c\u043e\u0440\u0444\u043e\u043c\u0435\u0442\u0440\u0438\u044f \u0445\u043e\u0440\u0438\u043e\u0438\u0434\u0435\u0438 \u0438 \u0432\u043d\u0443\u0442\u0440\u0435\u043d\u043d\u0438\u0445 \u0441\u043b\u043e\u0451\u0432 \u0441\u0435\u0442\u0447\u0430\u0442\u043a\u0438 \u043e\u0442\u0440\u0430\u0436\u0430\u0435\u0442 \u0441\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0435 \u043f\u0440\u043e\u0446\u0435\u0441\u0441\u044b \u0441\u0442\u0430\u0440\u0435\u043d\u0438\u044f. \u0412 \u043f\u0435\u0440\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u0435 \u044d\u0442\u0438 \u043f\u0430\u0440\u0430\u043c\u0435\u0442\u0440\u044b \u043c\u043e\u0433\u0443\u0442 \u0440\u0430\u0441\u0441\u043c\u0430\u0442\u0440\u0438\u0432\u0430\u0442\u044c\u0441\u044f \u043a\u0430\u043a \u043d\u0435\u0438\u043d\u0432\u0430\u0437\u0438\u0432\u043d\u044b\u0435 \u043c\u0430\u0440\u043a\u0435\u0440\u044b \u0431\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430.<\/jats:p>\n                  <jats:p>The search for accessible, non-invasive biomarkers to quantify the pace of systemic aging is a key priority in gerontology and personalized medicine. Aim \u2014 to evaluate associations between OCT-derived retinal and choroidal morphometric parameters and biological age in healthy adults. Materials and Methods: In the RussAge study, 148 clinically healthy volunteers (296 eyes), aged 22\u201374 years, underwent macular SS-OCT imaging using the Topcon Triton. Biological age was calculated using the PhenoAge algorithm. Structural changes in the retina and choroid showed concordance with biological age. Most parameters showed strong bilateral symmetry. Aging was associated with pronounced choroidal thinning (up to ~19%) and a moderate decrease in retinal nerve fiber layer thickness and the IPL+GCL complex (~5%), whereas INL and ONL+PIS remained relatively stable; similar patterns were observed when modeling biological and chronological age. OCT morphometry \u2014 particularly choroidal and inner retinal metrics \u2014 reflects systemic aging processes and may serve as non-invasive markers of biological aging.<\/jats:p>","DOI":"10.34922\/ae.2026.39.2.013","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T20:32:43Z","timestamp":1785702763000},"page":"267-273","source":"Crossref","is-referenced-by-count":0,"title":["\u041e\u041a\u0422-\u041f\u0410\u0420\u0410\u041c\u0415\u0422\u0420\u042b \u0421\u0415\u0422\u0427\u0410\u0422\u041a\u0418 \u0418 \u0425\u041e\u0420\u0418\u041e\u0418\u0414\u0415\u0418 \u041a\u0410\u041a \u041c\u0410\u0420\u041a\u0415\u0420\u042b \u0421\u0422\u0410\u0420\u0415\u041d\u0418\u042f: \u0421\u0412\u042f\u0417\u042c \u0421 \u0411\u0418\u041e\u041b\u041e\u0413\u0418\u0427\u0415\u0421\u041a\u0418\u041c \u0412\u041e\u0417\u0420\u0410\u0421\u0422\u041e\u041c \u0423 \u0417\u0414\u041e\u0420\u041e\u0412\u042b\u0425 \u041b\u0418\u0426 \u041f\u041e \u0414\u0410\u041d\u041d\u042b\u041c \u0418\u0421\u0421\u041b\u0415\u0414\u041e\u0412\u0410\u041d\u0418\u042f RussAge"],"prefix":"10.34922","volume":"39","author":[{"given":"\u0410.\u0421.","family":"\u0425\u0430\u043b\u0430\u0442\u044f\u043d","sequence":"first","affiliation":[{"name":"\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0433\u043b\u0430\u0437\u043d\u044b\u0445 \u0431\u043e\u043b\u0435\u0437\u043d\u0435\u0439 \u0438\u043c. \u041c.\u041c. \u041a\u0440\u0430\u0441\u043d\u043e\u0432\u0430"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u042e.","family":"\u042e\u0441\u0435\u0444","sequence":"first","affiliation":[{"name":"\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0433\u043b\u0430\u0437\u043d\u044b\u0445 \u0431\u043e\u043b\u0435\u0437\u043d\u0435\u0439 \u0438\u043c. \u041c.\u041c. \u041a\u0440\u0430\u0441\u043d\u043e\u0432\u0430"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u041a.\u0421.","family":"\u0410\u0432\u0435\u0442\u0438\u0441\u043e\u0432","sequence":"first","affiliation":[{"name":"\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u0433\u043b\u0430\u0437\u043d\u044b\u0445 \u0431\u043e\u043b\u0435\u0437\u043d\u0435\u0439 \u0438\u043c. \u041c.\u041c. \u041a\u0440\u0430\u0441\u043d\u043e\u0432\u0430"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u041b.\u0412.","family":"\u041c\u0430\u0447\u0435\u0445\u0438\u043d\u0430","sequence":"first","affiliation":[{"name":"\u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 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