{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:24:52Z","timestamp":1787066692572,"version":"build-2736575974"},"reference-count":11,"publisher":"Saint Petersburg Institute of Bioregulation and Gerontology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:p>\u041f\u0440\u043e\u0432\u0435\u0434\u0435\u043d \u0430\u043d\u0430\u043b\u0438\u0437 \u0447\u0430\u0441\u0442\u043e\u0442\u044b \u043f\u0440\u043e\u0433\u0440\u0435\u0441\u0441\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0425\u0411\u041f \u0438 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u043e\u0441\u043b\u043e\u0436\u043d\u0435\u043d\u0438\u0439 \u0443 318 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 80 \u043b\u0435\u0442 \u0438 \u0441\u0442\u0430\u0440\u0448\u0435 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 12 \u043c\u0435\u0441 \u043f\u043e\u0441\u043b\u0435 \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0430 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430 (\u0418\u041c) \u0441 \u043f\u043e\u0434\u044a\u0435\u043c\u043e\u043c \u0441\u0435\u0433\u043c\u0435\u043d\u0442\u0430 ST. \u041f\u0430\u0446\u0438\u0435\u043d\u0442\u044b \u0431\u044b\u043b\u0438 \u0440\u0430\u0437\u0434\u0435\u043b\u0435\u043d\u044b \u043d\u0430 \u0434\u0432\u0435 \u0433\u0440\u0443\u043f\u043f\u044b: \u0441 \u0425\u0411\u041f (n=164) \u0438 \u0431\u0435\u0437 \u0425\u0411\u041f (n=154). \u0423\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043e, \u0447\u0442\u043e \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0425\u0411\u041f \u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0430\u0446\u0438\u044f \u041a\u0418\u041c-1 (Kidney Injury Molecule-1) \u0432 \u043c\u043e\u0447\u0435 \u0438 \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u043c\u0438\u043a\u0440\u043e\u0430\u043b\u044c\u0431\u0443\u043c\u0438\u043d\u0443\u0440\u0438\u0438 (UACR) \u0431\u044b\u043b\u0438 \u0437\u043d\u0430\u0447\u0438\u043c\u043e \u0432\u044b\u0448\u0435 \u0438 \u043e\u0441\u0442\u0430\u0432\u0430\u043b\u0438\u0441\u044c \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u043c\u0438 \u0432 \u0442\u0435\u0447\u0435\u043d\u0438\u0435 \u0433\u043e\u0434\u0430, \u043a\u043e\u0440\u0440\u0435\u043b\u0438\u0440\u0443\u044f \u0441\u043e \u0441\u043a\u043e\u0440\u043e\u0441\u0442\u044c\u044e \u0441\u043d\u0438\u0436\u0435\u043d\u0438\u044f \u0421\u041a\u0424 (r=\u20130,47; p&lt;0,01) \u0438 \u0443\u0440\u043e\u0432\u043d\u0435\u043c NT-proBNP. \u041c\u0435\u0434\u0438\u0430\u043d\u0430 \u0432\u0440\u0435\u043c\u0435\u043d\u0438 \u0434\u043e \u043d\u0430\u0441\u0442\u0443\u043f\u043b\u0435\u043d\u0438\u044f \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u043e\u0433\u043e \u0441\u043e\u0431\u044b\u0442\u0438\u044f \u0432 \u0433\u0440\u0443\u043f\u043f\u0435 \u0425\u0411\u041f \u0441\u043e\u0441\u0442\u0430\u0432\u0438\u043b\u0430 198 [112; 289] \u0434\u043d\u0435\u0439 \u043f\u0440\u043e\u0442\u0438\u0432 312 [245; 358] \u0434\u043d\u0435\u0439 \u0432 \u0433\u0440\u0443\u043f\u043f\u0435 \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044f (p&lt;0,001). \u0420\u0438\u0441\u043a \u043a\u043e\u043c\u0431\u0438\u043d\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u043e\u0439 \u043a\u043e\u043d\u0435\u0447\u043d\u043e\u0439 \u0442\u043e\u0447\u043a\u0438 (\u0441\u043c\u0435\u0440\u0442\u044c, \u043f\u043e\u0432\u0442\u043e\u0440\u043d\u044b\u0439 \u0418\u041c, \u0438\u043d\u0441\u0443\u043b\u044c\u0442) \u0432 \u0433\u0440\u0443\u043f\u043f\u0435 \u0425\u0411\u041f \u0431\u044b\u043b \u0432 2,9 \u0440\u0430\u0437\u0430 \u0432\u044b\u0448\u0435 (p&lt;0,001). \u041d\u0435\u0437\u0430\u0432\u0438\u0441\u0438\u043c\u044b\u043c\u0438 \u043f\u0440\u0435\u0434\u0438\u043a\u0442\u043e\u0440\u0430\u043c\u0438 \u043d\u0435\u0431\u043b\u0430\u0433\u043e\u043f\u0440\u0438\u044f\u0442\u043d\u044b\u0445 \u0438\u0441\u0445\u043e\u0434\u043e\u0432 \u044f\u0432\u0438\u043b\u0438\u0441\u044c \u0443\u0440\u043e\u0432\u0435\u043d\u044c \u041a\u0418\u041c-1 &gt;1,5 \u043d\u0433\/\u043c\u043b (\u041e\u0420=2,3), UACR &gt;30 \u043c\u0433\/\u0433 (\u041e\u0420=2,1) \u0438 \u0430\u043d\u0435\u043c\u0438\u044f (\u041e\u0420=1,8). \u041f\u043e\u043b\u0443\u0447\u0435\u043d\u043d\u044b\u0435 \u0434\u0430\u043d\u043d\u044b\u0435 \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0430\u044e\u0442, \u0447\u0442\u043e \u041a\u0418\u041c-1 \u0438 \u043c\u0438\u043a\u0440\u043e\u0430\u043b\u044c\u0431\u0443\u043c\u0438\u043d\u0443\u0440\u0438\u044f \u044f\u0432\u043b\u044f\u044e\u0442\u0441\u044f \u0437\u043d\u0430\u0447\u0438\u043c\u044b\u043c\u0438 \u043f\u0440\u0435\u0434\u0438\u043a\u0442\u043e\u0440\u0430\u043c\u0438 \u043d\u0435\u0431\u043b\u0430\u0433\u043e\u043f\u0440\u0438\u044f\u0442\u043d\u043e\u0433\u043e \u0440\u0435\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0438 \u043a\u0430\u0440\u0434\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u043f\u0440\u043e\u0433\u043d\u043e\u0437\u0430 \u0443 \u0433\u0435\u0440\u0438\u0430\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432.<\/jats:p>\n                  <jats:p>The analysis of the progression of chronic kidney disease (CKD) and cardiovascular events was performed in 318 patients aged 80 years and older during 12 months after myocardial infarction (MI). Patients were divided into 2 groups: with CKD (n=164) and without CKD (n=154). It was found that in patients with CKD, the urinary concentration of KIM-1 and the level of microalbuminuria (UACR) were significantly higher and remained elevated during the year, correlating with the rate of eGFR decline (r=\u20130.47; p&lt;0.01) and NT-proBNP level. The median time to cardiovascular event in the CKD group was 198 [112; 289] days versus 312 [245; 358] days in the comparison group (p&lt;0.001). The risk of the composite endpoint (death, recurrent MI, stroke) in the CKD group was 2.9 times higher (p&lt;0.001). Independent predictors of adverse outcomes were KIM-1 &gt;1.5 ng\/ml (HR=2.3), UACR &gt;30 mg\/g (HR=2.1) and anemia (HR=1.8). The obtained data confirm that KIM-1 and microalbuminuria are significant predictors of adverse renal and cardiac prognosis in geriatric patients.<\/jats:p>","DOI":"10.34922\/ae.2026.39.3.005","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:51:48Z","timestamp":1787064708000},"page":"371-376","source":"Crossref","is-referenced-by-count":0,"title":["\u0425\u0420\u041e\u041d\u0418\u0427\u0415\u0421\u041a\u0410\u042f \u0411\u041e\u041b\u0415\u0417\u041d\u042c \u041f\u041e\u0427\u0415\u041a \u0423 \u041f\u0410\u0426\u0418\u0415\u041d\u0422\u041e\u0412 \u0421\u0422\u0410\u0420\u0428\u0415 80 \u041b\u0415\u0422, \u041f\u0415\u0420\u0415\u041d\u0415\u0421\u0428\u0418\u0425 \u0418\u041d\u0424\u0410\u0420\u041a\u0422 \u041c\u0418\u041e\u041a\u0410\u0420\u0414\u0410: \u041f\u0420\u041e\u0413\u041d\u041e\u0417\u0418\u0420\u041e\u0412\u0410\u041d\u0418\u0415 \u0418\u0421\u0425\u041e\u0414\u041e\u0412 (\u041f\u0420\u041e\u0421\u041f\u0415\u041a\u0422\u0418\u0412\u041d\u041e\u0415 12-\u041c\u0415\u0421\u042f\u0427\u041d\u041e\u0415 \u0418\u0421\u0421\u041b\u0415\u0414\u041e\u0412\u0410\u041d\u0418\u0415)"],"prefix":"10.34922","volume":"39","author":[{"given":"\u0418.\u0410.","family":"\u0417\u043e\u043b\u043e\u0442\u043e\u0432\u0441\u043a\u0430\u044f","sequence":"first","affiliation":[{"name":"\u0421\u0430\u043c\u0430\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u041c.\u0415.","family":"\u0420\u0430\u043c\u043e\u0434\u0438\u043d\u0430","sequence":"first","affiliation":[{"name":"\u0421\u0430\u043c\u0430\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u041c.\u0410.","family":"\u041f\u0430\u0448\u0438\u043d\u0430","sequence":"first","affiliation":[{"name":"\u0421\u0430\u043c\u0430\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u041f.\u0420.","family":"\u0428\u0430\u0446\u043a\u0430\u044f","sequence":"first","affiliation":[{"name":"\u0421\u0430\u043c\u0430\u0440\u0441\u043a\u0438\u0439 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u044b\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31754","reference":[{"key":"1","unstructured":"\u0414\u0435\u043c\u0447\u0443\u043a \u041e.\u0412., \u0421\u0443\u043a\u043c\u0430\u043d\u043e\u0432\u0430 \u0418.\u0410. \u041f\u0440\u043e\u0433\u043d\u043e\u0437\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0435 \u0447\u0430\u0441\u0442\u043e\u0442\u044b \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u043e\u0447\u0435\u043a \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441 \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u043e\u043c \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430 \u0438 \u043e\u0441\u0442\u0440\u044b\u043c \u043f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435\u043c \u043f\u043e\u0447\u0435\u043a \/\/ \u0420\u043e\u0441. \u043a\u0430\u0440\u0434\u0438\u043e\u043b. \u0436\u0443\u0440\u043d. 2023. \u0422. 28, \u2116 6. \u0421. 5247."},{"key":"2","unstructured":"\u0420\u044b\u0442\u043e\u0432\u0430 \u042e.\u041a., \u0413\u0443\u043b\u044f\u043d \u0420.\u0413., \u0428\u0430\u0445\u043d\u043e\u0432\u0438\u0447 \u0420.\u041c. \u0438 \u0434\u0440. \u0412\u043b\u0438\u044f\u043d\u0438\u0435 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043f\u043e\u0447\u0435\u043a \u043d\u0430 \u0442\u0435\u0447\u0435\u043d\u0438\u0435, \u043f\u0440\u043e\u0433\u043d\u043e\u0437 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0438\u043d\u0444\u0430\u0440\u043a\u0442\u0430 \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430 \u043f\u043e \u0434\u0430\u043d\u043d\u044b\u043c \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0433\u043e \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0430 \u0420\u0415\u0413\u0418\u041e\u041d\u0418\u041c \/\/ \u0420\u043e\u0441. \u043a\u0430\u0440\u0434\u0438\u043e\u043b. \u0436\u0443\u0440\u043d. 2025. \u0422. 30, \u2116 7. \u0421. 6257."},{"key":"3","unstructured":"\u0422\u043a\u0430\u0447\u0435\u0432\u0430 \u041e.\u041d., \u041a\u043e\u0442\u043e\u0432\u0441\u043a\u0430\u044f \u042e.\u0412., \u0411\u043e\u0431\u043a\u043e\u0432\u0430 \u0418.\u041d. \u0438 \u0434\u0440. \u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u043e\u0447\u0435\u043a \u0443 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u043f\u043e\u0436\u0438\u043b\u043e\u0433\u043e \u0438 \u0441\u0442\u0430\u0440\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430. \u0421\u043e\u0433\u043b\u0430\u0441\u043e\u0432\u0430\u043d\u043d\u043e\u0435 \u043c\u043d\u0435\u043d\u0438\u0435 \u044d\u043a\u0441\u043f\u0435\u0440\u0442\u043e\u0432 \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u043e\u0439 \u0430\u0441\u0441\u043e\u0446\u0438\u0430\u0446\u0438\u0438 \u0433\u0435\u0440\u043e\u043d\u0442\u043e\u043b\u043e\u0433\u043e\u0432 \u0438 \u0433\u0435\u0440\u0438\u0430\u0442\u0440\u043e\u0432 \u0438 \u041d\u0430\u0443\u0447\u043d\u043e\u0433\u043e \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0430 \u043d\u0435\u0444\u0440\u043e\u043b\u043e\u0433\u043e\u0432 \u0420\u043e\u0441\u0441\u0438\u0438 \/\/ \u0420\u043e\u0441. \u0436\u0443\u0440\u043d. \u0433\u0435\u0440\u0438\u0430\u0442. \u043c\u0435\u0434. 2024. \u2116 2. \u0421. 4\u201324."},{"key":"4","unstructured":"\u0424\u043e\u043c\u0438\u043d \u0412.\u0412., \u041c\u0438\u043b\u043e\u0432\u0430\u043d\u043e\u0432 \u042e.\u0421., \u041c\u0438\u043b\u043e\u0432\u0430\u043d\u043e\u0432\u0430 \u041b.\u042e. \u0438 \u0434\u0440. \u0425\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u043e\u0447\u0435\u043a \u0443 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