{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T19:35:12Z","timestamp":1725651312922},"reference-count":14,"publisher":"SGEM WORLD SCIENCE (SWS) Scholarly Society","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,25]]},"abstract":"<jats:p> Objectives: To identify quantitative variations of serum and saliva IL-1b related to the intensity of periodontal damage in patients associating thyroid autoantibodies. \nMaterial and method: The study group included a number of 70 patients with chronic autoimmune thyroiditis (CAT), that had oral examination and are classified by the presence and severity of chronic periodontitis (CP) lesions - mild (n = 20; 20.5%), medium (n = 14; 20%), severe (n = 12; 17%) and the absence of periodontal lesions (n = 24; 34.5%). Serum and salivary levels of IL-1b (ELISA) were assessed comparatively among the patients in the four study groups. \nResults: There were no significant differences between the median values of serum IL-b levels (pg\/ml) corresponding to the four study groups (2,44; 2,56; 1,97; 1,77) (p = 0,764), respectively the distribution of serum IL levels (pg \/ ml) are considered the same regardless of the presence or absence of periodontal lesions (p = 0,440). Significant differences were recorded between the median values of salivary IL levels (pg \/ ml) corresponding to the four studied groups (36,81; 51,22; 60,48; 21,47) (p less than 0.001, Median Test), respectively the distribution of mean values was different depending on the severity of periodontitis (p less than 0.001). \nConclusions: In patients with chronic autoimmune thyroiditis there is an intensified salivary inflammatory effect with a high degree of severity depending on the degree of periodontal damage. <\/jats:p>","DOI":"10.35603\/sws.iscss.2021\/s13.74","type":"proceedings-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T09:29:44Z","timestamp":1648805384000},"page":"677-694","source":"Crossref","is-referenced-by-count":0,"title":["INTERLEUKINE 1? - IN SERUM AND SALIVA IN PATIENTS WITH CHRONIC AUTOIMMUNE THYROIDITIS ASSOCIATING CHRONIC PERIODONTITIS \ufffd PARTICULARITIES OF EXPRESSION"],"prefix":"10.35603","volume":"8","author":[{"given":"Razvan","family":"Circo","sequence":"first","affiliation":[{"name":"Ovidius University of Constanta, Faculty of Dental Medicine","place":["Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seila","family":"Ibadula","sequence":"additional","affiliation":[{"name":"Ovidius University of Constanta, Faculty of Medicine","place":["Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Circo","sequence":"additional","affiliation":[{"name":"Ovidius University of Constanta, Faculty of Dental Medicine","place":["Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Badea","sequence":"additional","affiliation":[{"name":"Ovidius University of Constanta, Faculty of Medicine, Immunology Department","place":["Romania"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"21192","reference":[{"key":"ref=1","doi-asserted-by":"crossref","unstructured":"[1] Doa Elsayed Ramadanm, Ninuk Hariyani, Retno Indrawati, Rini Devijanti Ridwan, Indeswati Diyatri \ufffd \ufffdCytokines and Chemokines in Periodontitis\ufffd - Eur J Dent, 2020 Jul, 14.","DOI":"10.1055\/s-0040-1712718"},{"key":"ref=2","unstructured":"[2] Qingling, Guo, Ying, Wu, Yuanyuan, Hou, Yongping Liu, et al. \ufffd \ufffdCytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis\ufffd- Front Immunol, 218;9:1197."},{"key":"ref=3","doi-asserted-by":"crossref","unstructured":"[3] Zahra Heidari, Bita Moudi, Hamidreza Mahmoudzadeh-Sagheb \ufffd \ufffdImmunomodulatory factors gene polymorphisms in chronic periodontitis: an overview\ufffd- BMC Oral Health, 2019,19:29.","DOI":"10.1186\/s12903-019-0715-7"},{"key":"ref=4","unstructured":"[4] Vitaliy Shcherba, Mariia Kyryliv, Iryna Bekus, et al. \ufffd \ufffdA Comparative Study of Connective Tissue Metabolism Indices in Experimental Comorbidity-Free Periodontitis and Periodontitis Combined with Thyroid Dysfunction\ufffd \ufffd J Med Life, 2020;84(1):14- 23."},{"key":"ref=5","doi-asserted-by":"crossref","unstructured":"[5] Brodzikowska, A., Gorska, R., Kowalski, J. \ufffd \ufffdInterleukin-1 Genotype in Periodontitis\ufffd, Arch Immunol Ther Exp (warsz), 2019;67(6):367-373.","DOI":"10.1007\/s00005-019-00555-4"},{"key":"ref=6","doi-asserted-by":"crossref","unstructured":"[6] Josiane Bazzo de Alencar, Josns Maira Valentini Zacharias, Patricia Yumeko Tsuneto, Victor Hugo de Sonza et al. - \ufffdInfluence of Infammosome NLPRP3, and IL - 1? and IL-2 gene poloymorphisms in periodontitis susceptibility\ufffd \ufffd PlosOne, 2020;15(1):e0227905.","DOI":"10.1371\/journal.pone.0227905"},{"key":"ref=7","doi-asserted-by":"crossref","unstructured":"[7] Aldulayan, H.A, Coher, R.E., Stellrecht, E.M., Levine, L.M. \ufffd \ufffdRelationship between hypothyroidism and periodontitis: A scoping review\ufffd \ufffd Clin Exp Dent Res, 2020;6:147-157,10.1002\/crc 2.247.","DOI":"10.1002\/cre2.247"},{"key":"ref=8","doi-asserted-by":"crossref","unstructured":"[8] Jun Pei, Fei Li, Youhua Xie, Jing Liu, Tian Yu, Xiping Feng. \ufffd \ufffdMicrobial and metabolomic analysis of gingival crevicular fluid in general chronic periodontitis patients: lessons for a predictive, preventive, and personalized medical approach\ufffd, EPMA J, 2020;11(2):197-215.","DOI":"10.1007\/s13167-020-00202-5"},{"key":"ref=9","doi-asserted-by":"crossref","unstructured":"[9] Nirmita Dutta, Lillehoj, R.B, Estrela, P., Dutta,G. - ,, Electrochemical Biosensors for Cytokine Profiling: Recent Advancements and Possibilities in the Near Future\ufffd \ufffd Biosensors (Basel), 2021,Mar;11(3):94.","DOI":"10.3390\/bios11030094"},{"key":"ref=10","doi-asserted-by":"crossref","unstructured":"[10] Carlo Cafiero, Gianrico Spagnuolo, Gaetano Marenzi, Ranieri Martuscelli, Michele Colamaio, Stefania Leuci \ufffd \ufffdPredictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis\ufffd \ufffd J Clin Med, 2021, Apr:10(7):1488","DOI":"10.3390\/jcm10071488"},{"key":"ref=11","doi-asserted-by":"crossref","unstructured":"[11] Ran Cheng, Zhiwu Wu, Mingming Li, Meiying Shao, Tao Hu \ufffd \ufffdInterleukin-1? 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