{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:12:01Z","timestamp":1790871121295,"version":"4.1.0"},"reference-count":20,"publisher":"National Center for Global Health and Medicine (JST)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GHM"],"published-print":{"date-parts":[[2025,2,28]]},"DOI":"10.35772\/ghm.2024.01097","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T22:11:13Z","timestamp":1737756673000},"page":"67-71","source":"Crossref","is-referenced-by-count":2,"title":["Current global applications of HBcrAg assays in the management of chronic hepatitis B"],"prefix":"10.35772","volume":"7","author":[{"given":"Takako","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Nagoya City University Hospital, Nagoya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"21485","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Ko C, Chakraborty A, Chou WM, Hasreiter J, Wettengel JM, Stadler D, Bester R, Asen T, Zhang K, Wisskirchen K, McKeating JA, Ryu WS, Protzer U. Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels. J Hepatol. 2018; 69:1231-1241.","DOI":"10.1016\/j.jhep.2018.08.012"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Inoue T, Tanaka Y. The role of hepatitis B core-related antigen. Genes (Basel). 2019; 10:357.","DOI":"10.3390\/genes10050357"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Inoue T, Matsui T, Tanaka Y. Novel strategies for the early diagnosis of hepatitis B virus reactivation. Hepatol Res. 2021; 51:1033-1043.","DOI":"10.1111\/hepr.13699"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. H\u00f6ner Zu Siederdissen C, Maasoumy B, Cornberg M. What is new on HBsAg and other diagnostic markers in HBV infection? Best Pract Res Clin Gastroenterol. 2017; 31:281-289.","DOI":"10.1016\/j.bpg.2017.04.009"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Inoue T, Kusumoto S, Iio E, Ogawa S, Suzuki T, Yagi S, Kaneko A, Matsuura K, Aoyagi K, Tanaka Y. Clinical efficacy of a novel, high-sensitivity HBcrAg assay in the management of chronic hepatitis B and HBV reactivation. J Hepatol. 2021; 75:302-310.","DOI":"10.1016\/j.jhep.2021.02.017"},{"key":"6","unstructured":"6. Yagi S. Fundamental performance and clinical utilities of LumipulsePresto<sup>\u00ae<\/sup> iTACT<sup>\u00ae<\/sup> HBcrAg, a novel highly sensitive immunoassay for hepatitis B core-related antigen. Seibutsu Shiryo Bunseki. 2023; 46:149-158. (in Japanese)"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Inoue T, Tanaka Y. Hepatitis B virus and its sexually transmitted infection - an update. Microb Cell. 2016; 3:420-437.","DOI":"10.15698\/mic2016.09.527"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Terrault NA, Lok ASF, McMahon BJ, Chang KM, Hwang JP, Jonas MM, Brown RS, Jr., Bzowej NH, Wong JB. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology. 2018; 67:1560-1599.","DOI":"10.1002\/hep.29800"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017; 67:370-398.","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"10","unstructured":"10. WHO Guidelines Approved by the Guidelines Review Committee. Prevention of mother-to-child transmission of hepatitis B virus: Guidelines on antiviral prophylaxis in pregnancy. Geneva: World Health Organization; 2020."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Shimakawa Y, Veillon P, Birguel J, Pivert A, Sauvage V, Guillou-Guillemette HL, Roger S, Njouom R, Ducancelle A, Amta P, Huraux JM, Adoukara JP, Lunel-Fabiani F. Residual risk of mother-to-child transmission of hepatitis B virus infection despite timely birth-dose vaccination in Cameroon (ANRS 12303): A single-centre, longitudinal observational study. Lancet Glob Health. 2022; 10:e521-e529.","DOI":"10.1016\/S2214-109X(22)00026-2"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Inoue T, Yagi S, Tanaka Y. Two concepts of hepatitis B core-related antigen assay: A highly sensitive and rapid assay or an effective tool for widespread screening. Viruses. 2024; 16:848.","DOI":"10.3390\/v16060848"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Rokuhara A, Tanaka E, Matsumoto A, Kimura T, Yamaura T, Orii K, Sun X, Yagi S, Maki N, Kiyosawa K. Clinical evaluation of a new enzyme immunoassay for hepatitis B virus core-related antigen; a marker distinct from viral DNA for monitoring lamivudine treatment. J Viral Hepat. 2003; 10:324-330.","DOI":"10.1046\/j.1365-2893.2003.00437.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Maasoumy B, Wiegand SB, Jaroszewicz J, Bremer B, Lehmann P, Deterding K, Taranta A, Manns MP, Wedemeyer H, Glebe D, Cornberg M. Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected with genotypes A and D. Clin Microbiol Infect. 2015; 21:606.e1-e10.","DOI":"10.1016\/j.cmi.2015.02.010"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Suzuki T, Inoue T, Matsuura K, Kusumoto S, Hagiwara S, Ogawa S, Yagi S, Kaneko A, Fujiwara K, Watanabe T, Aoyagi K, Urata Y, Tamori A, Kataoka H, Tanaka Y. Clinical usefulness of a novel high-sensitivity hepatitis B core-related antigen assay to determine the initiation of treatment for HBV reactivation. J Gastroenterol. 2022; 57:486-494.","DOI":"10.1007\/s00535-022-01872-w"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Hagiwara S, Kusumoto S, Inoue T, Ogawa S, Narita T, Ito A, Ri M, Komatsu H, Suzuki T, Matsuura K, Yagi S, Kaneko A, Aoyagi K, Iida S, Tanaka Y. Management of hepatitis B virus (HBV) reactivation in patients with resolved HBV infection based on a highly sensitive HB core-related antigen assay. Hepatol Res. 2022; 52:745-753.","DOI":"10.1111\/hepr.13761"},{"key":"17","unstructured":"17. World Health Organization. Global progress report on HIV, viral hepatitis and sexually transmitted infections. <i>https:\/\/www.globalhep.org\/sites\/default\/files\/content\/resource\/files\/2021-05\/WHO%20Progress%20Report%202021.pdf<\/i> (accessed December 29, 2024)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Mak LY, Hui RW, Cheung KS, Fung J, Seto WK, Yuen MF. Advances in determining new treatments for hepatitis B infection by utilizing existing and novel biomarkers. Expert Opin Drug Discov. 2023; 18:401-416.","DOI":"10.1080\/17460441.2023.2192920"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Shimakawa Y, Ndow G, Njie R, <i>et al.<\/i> Hepatitis B core-related antigen: An alternative to hepatitis B virus DNA to assess treatment eligibility in Africa. Clin Infect Dis. 2020; 70:1442-1452.","DOI":"10.1093\/cid\/ciz412"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Shimakawa Y, Ndow G, Kaneko A, Aoyagi K, Lemoine M, Tanaka Y; PROLIFICA\/HBCRAG-RDT STUDY GROUP. Rapid point-of-care test for hepatitis B core-related antigen to diagnose high viral load in resource-limited settings. Clin Gastroenterol Hepatol. 2023; 21:1943-1946.e2.","DOI":"10.1016\/j.cgh.2022.05.026"}],"container-title":["Global Health &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ghm\/7\/1\/7_2024.01097\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T04:11:05Z","timestamp":1741407065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/ghm\/7\/1\/7_2024.01097\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.35772\/ghm.2024.01097","relation":{},"ISSN":["2434-9186","2434-9194"],"issn-type":[{"value":"2434-9186","type":"print"},{"value":"2434-9194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"article-number":"2024.01097"}}