{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T15:02:52Z","timestamp":1726498972569},"reference-count":0,"publisher":"American Society of Interventional Pain Physicians","issue":"4;2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Phys"],"published-print":{"date-parts":[[2020,4,14]]},"abstract":"<jats:p>Background: Percutaneous endoscopic lumbar discectomy (PELD) can only relieve mechanical\ncompression but cannot directly reduce the inflammatory reaction of the adjacent nerve root,\nwhich contributes to persistent pain and physical disabilities postoperatively. Numerous studies\nhave explored the application of epidural steroids after an open lumbar discectomy in relieving pain\nby reducing local inflammatory reactions and further peridural scar formation.\nObjectives: To explore that whether \u201ccocktail treatment\u201d in which a gelatin sponge was\nimpregnated with ropivacaine, dexamethasone, and vitamin B12 promoted early postoperative\nrecovery after PELD.\nStudy Design: Retrospective, case-controlled study.\nSetting: All data were from Hong-Hui Hospital in Xi\u2019an.\nMethods: Between January 2016 and January 2017, 100 patients of single-level lumbar disc\nherniation were treated with PELD in our hospitals. The cocktail treatment was applied in the first\n50 patients (group cocktail), and an equal size gelatin sponge without drugs was used in the other\n50 patients as control (group noncocktail). The clinical outcome evaluation included the Visual\nAnalog Scale (VAS) score for back and leg pain and Oswestry Disability Index (ODI) score.\nResults: There was a significant difference in the mean periods of return to work (4.25 \u00b1 1.88\nweeks in the cocktail group and 5.18 \u00b1 2.19 weeks in the noncocktail group) (P &lt; 0.01). Compared\nwith the preoperative data, a significant improvement in VAS scores of back pain and sciatica\nand ODI were observed in each follow-up interval (P &lt; 0.05, respectively). In the noncocktail\ngroup, there were visible fluctuations in the 3 indicators within the first week after surgery. This\nphenomenon was not observed in the cocktail group, a difference that was statistically significant\n(P &lt; 0.05, respectively). In further follow-up, no significant differences were observed between the\n2 groups (P &gt; 0.05, respectively).\nLimitations: The nonrandomized, single-center, retrospective design is a major limitation of this\nstudy.\nConclusions: The \u201ccocktail treatment\u201d with a gelatin sponge impregnated with ropivacaine,\ndexamethasone, and vitamin B12 promotes early and satisfactory back and leg pain relief and fast\nfunctional recovery after PELD.\nKey words: Endoscopic lumbar discectomy, lumbar disc herniation, steroids, nerve root block,\ngelatin sponge<\/jats:p>","DOI":"10.36076\/ppj.2020\/23\/e211","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T10:12:21Z","timestamp":1616667141000},"page":"E211-E218","source":"Crossref","is-referenced-by-count":3,"title":["Cocktail Treatment with a Gelatin Sponge\nImpregnated with Ropivacaine, Dexamethasone,\nand Vitamin B12 Promotes Early Postoperative\nRecovery after Percutaneous Endoscopic Lumbar\nDiscectomy: A Retrospective, Case-Controlled Study"],"prefix":"10.36076","volume":"2;23","author":[{"suffix":"MD","given":"Ding-Jun","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, Honghui Hospital, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"21814","published-online":{"date-parts":[[2020,4,15]]},"container-title":["Pain Physician"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T10:12:22Z","timestamp":1616667142000},"score":1,"resource":{"primary":{"URL":"https:\/\/painphysicianjournal.com\/current\/pdf?article=NzA0Ng%3D%3D&journal=125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":0,"issue-title":["March 2020"],"journal-issue":{"issue":"4;2","published-online":{"date-parts":[[2020,3,5]]},"published-print":{"date-parts":[[2020,3,4]]}},"URL":"https:\/\/doi.org\/10.36076\/ppj.2020\/23\/e211","archive":["Internet Archive","Internet Archive"],"relation":{},"ISSN":["2150-1149","1533-3159"],"issn-type":[{"type":"electronic","value":"2150-1149"},{"type":"print","value":"1533-3159"}],"subject":[],"published":{"date-parts":[[2020,4,14]]}}}