{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:28:18Z","timestamp":1783664898573,"version":"3.55.0"},"reference-count":8,"publisher":"Innovative Healthcare Institute","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Soft-tissue sarcomas associated with eosinophilia are rare, with limited cases reported in adults, and even fewer in the pediatric population. In this report, we highlight the importance of malignancy in the differential of hypereosinophilia in an adolescent. A 17-year-old boy presented with incidental findings of multiple bilateral pulmonary nodules on chest computed tomography (CT), and hypereosinophilia (absolute eosinophilic count [AEC] 7029 cells\/mm3, hypereosinophilia defined as AEC &amp;gt;1500 cells\/mm3). Lung biopsy showed high-grade metastatic sarcoma. A positron emission tomography\u2013computed tomography (PET-CT) demonstrated a 7.9-cm mass in the left thigh, with biopsy revealing dedifferentiated liposarcoma. Subsequently, the patient was diagnosed with liposarcoma, with lung, mediastinal, and brain metastases. He completed six cycles of ifosfamide\/doxorubicin, followed by surgical resection of primary thigh tumor and brain lesion. Given widely metastatic disease, he received palliative chemotherapy, and later transitioned to hospice. The patient died of respiratory failure from malignant pleural effusions. In conclusion, this case demonstrates the importance of a having a broad differential for hypereosinophilia, including malignancy, to expedite the diagnosis and initiate appropriate management promptly.<\/jats:p>","DOI":"10.36401\/jipo-20-23","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T18:41:49Z","timestamp":1603996909000},"page":"21-25","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Metastatic Dedifferentiated Liposarcoma Presenting as Hypereosinophilia in an Adolescent"],"prefix":"10.36401","volume":"4","author":[{"given":"Sadhana","family":"Balasubramanyam","sequence":"first","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joud","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX, USA"},{"name":"Texas Children's Hospital, Houston, TX, USA"},{"name":"William T. Shearer Center for Human Immunobiology, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22027","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"2022020319373111200_i2590-017X-4-1-21-b01","doi-asserted-by":"crossref","unstructured":"MacMohan\n              H,\n            \n            \n              Austin\n              JHM,\n            \n            \n              Gamsu\n              G,\n            \n            et al.\n\t\t\t\t\t\n          Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society.\n\t\t\t\t\tRadiology.\n\t\t\t\t\t2005;\n\t\t\t\t\t237:\n\t\t\t\t\t395\u2013\n\t\t\t\t\t400.","DOI":"10.1148\/radiol.2372041887"},{"key":"2022020319373111200_i2590-017X-4-1-21-b02","doi-asserted-by":"crossref","unstructured":"Klion\n              AD.\n            \n          \n          How I treat 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hypereosinophilia.\n\t\t\t\t\tCureus.\n\t\t\t\t\t2018;\n\t\t\t\t\t10:\n\t\t\t\t\te2866.","DOI":"10.7759\/cureus.2866"},{"key":"2022020319373111200_i2590-017X-4-1-21-b05","doi-asserted-by":"crossref","unstructured":"Snyder\n              MC,\n            \n            \n              Lauter\n              CB.\n            \n          \n          Eosinophilic and neutrophilic leukemoid reaction in a woman with spindle-cell sarcoma: a case report.\n\t\t\t\t\tJ Med Case Rep.\n\t\t\t\t\t2010;\n\t\t\t\t\t4:\n\t\t\t\t\t335.","DOI":"10.1186\/1752-1947-4-335"},{"key":"2022020319373111200_i2590-017X-4-1-21-b06","unstructured":"Latif\n              N,\n            \n            \n              Zaiden\n              R,\n            \n            \n              Pham\n              D,\n            \n            \n              Rana\n              F.\n            \n          \n          Soft tissue sarcoma mimicking eosinophilic leukemia.\n\t\t\t\t\tClin Adv Hematol Oncol.\n\t\t\t\t\t2010;\n\t\t\t\t\t8:\n\t\t\t\t\t899\u2013\n\t\t\t\t\t903."},{"key":"2022020319373111200_i2590-017X-4-1-21-b07","doi-asserted-by":"crossref","unstructured":"Davis\n              BP,\n            \n            \n              Rothenberg\n              ME.\n            \n          \n          Eosinophils and cancer.\n\t\t\t\t\tCancer Immunol Res.\n\t\t\t\t\t2014;\n\t\t\t\t\t2:\n\t\t\t\t\t1\u2013\n\t\t\t\t\t8.","DOI":"10.1158\/2326-6066.CIR-13-0196"},{"key":"2022020319373111200_i2590-017X-4-1-21-b08","doi-asserted-by":"crossref","unstructured":"Cormier\n              SA,\n            \n            \n              Taranova\n              AG,\n            \n            \n              Bedient\n              C,\n            \n            et al.\n\t\t\t\t\t\n          Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response.\n\t\t\t\t\tJ Leukoc Biol.\n\t\t\t\t\t2006;\n\t\t\t\t\t79:\n\t\t\t\t\t1131\u2013\n\t\t\t\t\t1139.","DOI":"10.1189\/jlb.0106027"}],"container-title":["Journal of Immunotherapy and Precision Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/meridian.allenpress.com\/innovationsjournals-JIPO\/article-pdf\/4\/1\/21\/3010577\/i2590-017x-4-1-21.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/meridian.allenpress.com\/innovationsjournals-JIPO\/article-pdf\/4\/1\/21\/3010577\/i2590-017x-4-1-21.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T17:48:42Z","timestamp":1765475322000},"score":1,"resource":{"primary":{"URL":"https:\/\/innovationsjournals-jipo.kglmeridian.com\/view\/journals\/jipo\/4\/1\/article-p21.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,10,29]]},"published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.36401\/jipo-20-23","relation":{},"ISSN":["2590-017X","2666-2345"],"issn-type":[{"value":"2590-017X","type":"electronic"},{"value":"2666-2345","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,29]]}}}