{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:25:51Z","timestamp":1747221951603,"version":"3.40.5"},"reference-count":40,"publisher":"Sociedade Brasileira de Pneumologia e Tisiologia","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bras Pneumol."],"abstract":"<jats:p>Objective: To assess the relative frequency of incident cases of interstitial lung diseases (ILDs) in Brazil. Methods: This was a retrospective survey of new cases of ILD in six referral centers between January of 2013 and January of 2020. The diagnosis of ILD followed the criteria suggested by international bodies or was made through multidisciplinary discussion (MDD). The condition was characterized as unclassifiable ILD when there was no specific final diagnosis following MDD or when there was disagreement between clinical, radiological, or histological data. Results: The sample comprised 1,406 patients (mean age = 61 \u00b1 14 years), and 764 (54%) were female. Of the 747 cases exposed to hypersensitivity pneumonitis (HP)-related antigens, 327 (44%) had a final diagnosis of HP. A family history of ILD was reported in 8% of cases. HRCT findings were indicative of fibrosis in 74% of cases, including honeycombing, in 21%. Relevant autoantibodies were detected in 33% of cases. Transbronchial biopsy was performed in 23% of patients, and surgical lung biopsy, in 17%. The final diagnoses were: connective tissue disease-associated ILD (in 27%), HP (in 23%), idiopathic pulmonary fibrosis (in 14%), unclassifiable ILD (in 10%), and sarcoidosis (in 6%). Diagnoses varied significantly among centers (?2 = 312.4; p &lt; 0.001). Conclusions: Our findings show that connective tissue disease-associated ILD is the most common ILD in Brazil, followed by HP. These results highlight the need for close collaboration between pulmonologists and rheumatologists, the importance of detailed questioning of patients in regard with potential exposure to antigens, and the need for public health campaigns to stress the importance of avoiding such exposure.<\/jats:p>","DOI":"10.36416\/1806-3756\/e20230232","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T15:49:25Z","timestamp":1709221765000},"page":"e20230232","source":"Crossref","is-referenced-by-count":1,"title":["Relative incidence of interstitial lung diseases in Brazil"],"prefix":"10.36416","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0953-5605","authenticated-orcid":false,"given":"Simone","family":"Lobo Krupok Matias1","sequence":"first","affiliation":[{"name":"1. Hospital S\u00e3o Paulo, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo (SP) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0352-9589","authenticated-orcid":false,"given":"Carlos","family":"Alberto de Castro Pereira1","sequence":"additional","affiliation":[{"name":"1. Hospital S\u00e3o Paulo, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo (SP) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-2533","authenticated-orcid":false,"given":"Maria","family":"Raquel Soares1","sequence":"additional","affiliation":[{"name":"1. Hospital S\u00e3o Paulo, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo (SP) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-2877","authenticated-orcid":false,"given":"Fl\u00e1via","family":"Castro Velasco Fernandes2","sequence":"additional","affiliation":[{"name":"2. Hospital das Cl\u00ednicas, Universidade Federal de Goi\u00e1s, Goi\u00e2nia (GO) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-2533","authenticated-orcid":false,"given":"Maria","family":"Auxiliadora Carmo Moreira2","sequence":"additional","affiliation":[{"name":"2. Hospital das Cl\u00ednicas, Universidade Federal de Goi\u00e1s, Goi\u00e2nia (GO) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4733-4282","authenticated-orcid":false,"given":"Fernanda","family":"Maciel de Aguiar Baptista3","sequence":"additional","affiliation":[{"name":"3. Hospital S\u00e3o Rafael, Instituto D\u2019Or de Ensino e Pesquisa em Salvador, Salvador (BA) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4765-2685","authenticated-orcid":false,"given":"Tarciane","family":"Aline Prata4","sequence":"additional","affiliation":[{"name":"4. Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais, Hospital J\u00falia Kubistchek, Belo Horizonte (MG) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2657-5481","authenticated-orcid":false,"given":"Gediel","family":"Cordeiro Junior4","sequence":"additional","affiliation":[{"name":"4. Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais, Hospital J\u00falia Kubistchek, Belo Horizonte (MG) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-875X","authenticated-orcid":false,"given":"Eliane","family":"Viana Mancuzo5","sequence":"additional","affiliation":[{"name":"5. Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, Belo Horizonte (MG) Brasil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22288","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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