{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:10:05Z","timestamp":1788876605958,"version":"build-2803163510"},"reference-count":15,"publisher":"Sociedade Brasileira de Pneumologia e Tisiologia","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.pt-br"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respir Res Clin Pract"],"DOI":"10.36416\/1806-3756\/e20260412","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:39:50Z","timestamp":1788874790000},"page":"e20260412","source":"Crossref","is-referenced-by-count":0,"title":["Adaptive clinical trials: key concepts for clinical researchers"],"prefix":"10.36416","author":[{"given":"Victor","family":"Zuniga Dourado","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k5swt12","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Patino","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k5swt12","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Carvalho Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22288","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref0","unstructured":"1. Simoes MDSMP, Proen\u00e7a NL, Lauria VT, do Nascimento MB,"},{"key":"ref1","unstructured":"Padovani RDC, Dourado VZ. Effects of Using a Smartphone App"},{"key":"ref2","unstructured":"Combined With Behavior Change Techniques on the Level of"},{"key":"ref3","unstructured":"Physical Activity Among Adults and Older Adults: Sequential Multiple"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Assignment Randomized Trial. J Med Internet Res. 2026;28:e73388.","DOI":"10.2196\/73388"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.2196\/73388","DOI":"10.2196\/73388"},{"key":"ref6","unstructured":"2. Morais Pereira Sim\u00f5es MDS, de Barros Gonze B, Leite Proen\u00e7a N,"},{"key":"ref7","unstructured":"Tonon Lauria V, Demarchi Silva Terra V, da Costa Padovani R, Zuniga"},{"key":"ref8","unstructured":"Dourado V. Use of a smartphone app combined with gamification"},{"key":"ref9","unstructured":"to increase the level of physical activity of adults and older adults:"},{"key":"ref10","unstructured":"protocol of a sequential multiple assignment randomized trial. Trials."},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"2019;20(1):780. https:\/\/doi.org\/10.1186\/s13063-019-3879-1","DOI":"10.1186\/s13063-019-3879-1"},{"key":"ref12","unstructured":"3. Ryan EG, Couturier DL, Heritier S. Bayesian adaptive clinical trial"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"designs for respiratory medicine. Respirology. 2022;27(10):834-843.","DOI":"10.1111\/resp.14337"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1111\/resp.14337","DOI":"10.1111\/resp.14337"}],"container-title":["Respiratory Research &amp; Clinical Practice"],"original-title":[],"link":[{"URL":"https:\/\/www.crossref.org\/categories\/similarity-check\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:39:54Z","timestamp":1788874794000},"score":1,"resource":{"primary":{"URL":"https:\/\/rrcpjournal.org\/article\/adaptive-clinical-trials-key-concepts-for-clinical-researchers\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":15,"URL":"https:\/\/doi.org\/10.36416\/1806-3756\/e20260412","relation":{},"ISSN":["3086-3910"],"issn-type":[{"value":"3086-3910","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"article-number":"2026-0412"}}