{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:10:58Z","timestamp":1755216658942,"version":"3.43.0"},"reference-count":18,"publisher":"The Journal of Health Economics and Outcomes Research","issue":"2","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["jheor.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"background\"> <jats:title>Background<\/jats:title> <jats:p>Postoperative urinary retention (POUR) is a common and distressing surgical complication that may be associated with the pharmacological reversal technique of neuromuscular blockade (NMB).<\/jats:p> <\/jats:sec> <jats:sec id=\"objective\"> <jats:title>Objective<\/jats:title> <jats:p>This study aimed to investigate the impact that POUR has on medical charges.<\/jats:p> <\/jats:sec> <jats:sec id=\"methods\"> <jats:title>Methods<\/jats:title> <jats:p>This was a retrospective observational study of adult patients undergoing select surgeries who were administered neuromuscular blockade agent (NMBA), which was pharmacologically reversed between February 2017 and November 2021 using data from the PINC-AI\u2122 Healthcare Database. Patients were divided into 2 groups: those experiencing POUR (composite of retention of urine, insertion of temporary indwelling bladder catheter, insertion of non-indwelling bladder catheter) during index hospitalization following surgery and those without POUR. Surgeries in inpatient and outpatient settings were analyzed separately. A cross-sectional comparison was performed to report total hospital charges for the 2 groups. Furthermore, patients experiencing subsequent POUR events within three days after discharge from index hospitalization were studied.<\/jats:p> <\/jats:sec> <jats:sec id=\"results\"> <jats:title>Results<\/jats:title> <jats:p>A total of 330\u202f838 inpatients and 437\u202f063 outpatients were included. POUR developed in 13\u202f020 inpatients and 2756 outpatients. Unadjusted results showed that POUR was associated with greater charges in both inpatient ($92\u202f529 with POUR vs $78\u202f556 without POUR, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and outpatient ($48\u202f996 with POUR vs $35\u202f433 without POUR, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) settings. After adjusting for confounders, POUR was found to be associated with greater charges with an overall mean adjusted difference of $10\u202f668 (95% confidence interval [CI] $95\u2009760-$11\u202f760, p\u2009&lt;\u2009.001) in inpatient and $13\u202f160 (95% CI $11\u202f750-$14\u2009\u202f571, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) in outpatient settings. Charges associated with subsequent POUR events following discharge ranged from $9418 inpatient charges to $1694 outpatient charges.<\/jats:p> <\/jats:sec> <jats:sec id=\"conclusions\"> <jats:title>Conclusions<\/jats:title> <jats:p>Surgical patients who were pharmacologically reversed for NMB and developed a POUR event incurred greater charges than patients without POUR. These findings support the use of NMB reversal agents associated with a lower incidence of POUR.<\/jats:p> <\/jats:sec>","DOI":"10.36469\/001c.121641","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T12:37:10Z","timestamp":1723120630000},"update-policy":"https:\/\/doi.org\/10.36469\/00001","source":"Crossref","is-referenced-by-count":0,"title":["Economic Impact of Postoperative Urinary Retention in the US Hospital Setting"],"prefix":"10.36469","volume":"11","author":[{"given":"Weijia","family":"Wang","sequence":"first","affiliation":[{"name":"Outcomes Research, Merck & Co., Inc., Rahway, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arielle","family":"Marks-Anglin","sequence":"additional","affiliation":[{"name":"Outcomes Research, Merck & Co., Inc., Rahway, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Turzhitsky","sequence":"additional","affiliation":[{"name":"Outcomes Research, Merck & Co., Inc., Rahway, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Mark","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Merck & Co., Inc., Rahway, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Otero Rosales","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Merck & Co., Inc., Rahway, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel W.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Global Scientific Affairs, Merck & Co., Inc., Rahway, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Health Economics and Decision Science, Merck Sharp & Dohme (UK) Ltd., London, UK","department":["Biostatistics and Research Decision Sciences"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Abueg","sequence":"additional","affiliation":[{"name":"Global Medical Affairs, Merck & Co., Inc., Rahway, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira S.","family":"Hofer","sequence":"additional","affiliation":[{"name":"Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA","department":["Department of Anesthesiology, Pain, and Perioperative Medicine; Department of Medicine, Division of Data Driven Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby N.","family":"Weingarten","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine, Rochester, Minnesota, USA","department":["Department of Anesthesiology and Perioperative Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22273","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1213\/00000539-197703000-00004","article-title":"A comparison of glycopyrrolate and atropine during reversal of nondepolarizing neuromuscular block with neostigmine","volume":"56","author":"G. 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