{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T19:59:13Z","timestamp":1765915153493,"version":"3.48.0"},"reference-count":22,"publisher":"The Journal of Health Economics and Outcomes Research","issue":"1","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["jheor.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"background\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary vein isolation (PVI) is the main ablation strategy for the treatment of paroxysmal atrial fibrillation. Different technologies are available for PVI, including various cryoballoon catheters (CB-A). Compared with the Arctic Front Advance Pro\u2122, the novel POLARx FIT\u2122 CB-A might reduce costs for atrial fibrillation ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"objective\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to perform a health economic evaluation of two cryoballoon systems for PVI procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All patients undergoing their first PVI procedure with POLARx FIT\u2122 CB-A or the Arctic Front Advance Pro\u2122 CB-A were prospectively enrolled. The health economic analysis was performed on the index hospitalization and procedure. The primary safety endpoint included procedure-related adverse events within the index hospitalization. A decision tree model was built to estimate downstream costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 80 patients with paroxysmal atrial fibrillation undergoing PVI were analyzed, with 40 patients in each arm. Compared with the Arctic Front Advance Pro\u2122 CB-A, POLARx FIT\u2122 CB-A showed a lower procedure time, left-atrium dwell time, and fluoroscopy time. The complication rate was low (6.3%) and included 3 reversible phrenic nerve palsies in the POLARx FIT\u2122 CB-A group vs 2 in the Arctic Front Advance Pro\u2122 CB-A group. Compared with the Arctic Front Advance Pro, the POLARx FIT\u2122 CB-A was associated with lower procedural costs (\u20ac2069.7\u2009\u00b1\u2009\u20ac165.2 vs \u20ac2239.5\u2009\u00b1\u2009 \u20ac366.0;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"conclusion\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The POLARx FIT\u2122 CB-A was associated with a shorter procedure time, translating into lower procedural costs, compared with the Arctic Front Advance Pro. Complications were rare and comparable between the two technologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.36469\/001c.133223","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T09:45:00Z","timestamp":1745228700000},"update-policy":"https:\/\/doi.org\/10.36469\/00001","source":"Crossref","is-referenced-by-count":0,"title":["Cryoballoon Ablation With the POLARx FIT or the Arctic Front Advance Pro for Paroxysmal Atrial Fibrillation: A Health Economic Analysis"],"prefix":"10.36469","volume":"12","author":[{"given":"Luigi","family":"Pannone","sequence":"first","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Uffenorde","sequence":"additional","affiliation":[{"name":"Boston Scientific Medizintechnik GmbH, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Bosworth Smith","sequence":"additional","affiliation":[{"name":"Coreva Scientific GmbH & Co KG, Koenigswinter, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico Giovanni","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Vergara","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Doundoulakis","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Sorgente","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvise","family":"Del Monte","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Talevi","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Overeinder","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gezim","family":"Bala","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Almorad","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Str\u00f6ker","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sieira","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Gharaviri","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"La Meir","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Brugada","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Sarkozy","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Battista","family":"Chierchia","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"de Asmundis","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel, European Reference Networks Guard-Heart, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22273","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1093\/europace\/eut380","article-title":"Cost-effectiveness of cryoballoon ablation for the management of paroxysmal atrial fibrillation","volume":"16","author":"M. 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Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1080\/13696998.2024.2369433","article-title":"A cost-consequence analysis comparing three cardiac ablation strategies for the treatment of paroxysmal atrial fibrillation","volume":"27","author":"M. van de Kar","year":"2024","journal-title":"J Med Econ"},{"key":"ref13","first-page":"20200455","article-title":"Procedural safety and efficacy for pulmonary vein isolation with the novel PolarxTM cryoablation system: a propensity score matched comparison with the Arctic FrontTM cryoballoon in the setting of paroxysmal atrial fibrillation","volume":"14","author":"J. 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Cronin","year":"2024","journal-title":"Circulation"},{"key":"ref20","first-page":"2235","article-title":"2016-FIRE and ICE-NEJM (cryoballoon or radiofrequency ablation for paroxysmal AF)","volume":"374","author":"K.-H. Kuck","year":"2016","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1056\/NEJMoa2307291","article-title":"Pulsed field or conventional thermal ablation for paroxysmal atrial fibrillation","volume":"389","author":"V. Y. Reddy","year":"2023","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"e002423","DOI":"10.1136\/openhrt-2023-002423","article-title":"Economic evaluation of first-line cryoballoon ablation versus antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation from an English National Health Service perspective","volume":"11","author":"J. Paisey","year":"2024","journal-title":"Open Heart"}],"container-title":["Journal of Health Economics and Outcomes Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jheor.org\/article\/133223-cryoballoon-ablation-with-the-polarx-fit-or-the-arctic-front-advance-pro-for-paroxysmal-atrial-fibrillation-a-health-economic-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T19:54:42Z","timestamp":1765914882000},"score":1,"resource":{"primary":{"URL":"https:\/\/jheor.org\/article\/133223-cryoballoon-ablation-with-the-polarx-fit-or-the-arctic-front-advance-pro-for-paroxysmal-atrial-fibrillation-a-health-economic-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.36469\/001c.133223","relation":{},"ISSN":["2327-2236"],"issn-type":[{"type":"electronic","value":"2327-2236"}],"subject":[],"published":{"date-parts":[[2025,4,21]]}}}