{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:25:13Z","timestamp":1785414313034,"version":"3.56.0"},"reference-count":22,"publisher":"The Journal of Health Economics and Outcomes Research","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["jheor.org"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background<\/jats:title>\n Continuous diffusion of oxygen (CDO) to wounds has demonstrated better effectiveness in healing wounds than negative-pressure wound therapy (NPWT). However, there is limited evidence regarding the cost-effectiveness of CDO therapy and its comparison with NPWT.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n The purpose of this analysis is to report on the cost-effectiveness of CDO and NPWT using published clinical results as well as real-world clinical outcomes and cost information. The objectives included analyzing the cost-effectiveness of CDO therapy across multiple wound types and anatomical locations, testing the data for robustness, and comparing the cost-effectiveness using results from controlled clinical studies for CDO and NPWT.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective patients database using real-world clinical results of 764 patients treated using CDO therapy in a broad range of clinical practices across a wide range of wound types and wound locations was analyzed. The clinical data were combined with real world billing data to draw statistically valid cost comparisons. Using 3 methodologies, the cost savings were demonstrated across 2 healthcare systems.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In the US, the average cost savings of CDO was US $14\u2009238 vs NPWT to heal a wound. Kaplan-Meier analysis showed that CDO use in clinical practice had 79.2% full closure in 112 days compared with NPWT, which has 43.2% full closure in the same timeframe for similar wound sizes and severity.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n There are two primary reasons for the significant cost savings. First, CDO therapy is much easier to apply and maintain than traditional NPWT, as CDO dressings can easily be changed by patients at home without the assistance of a nurse. The second reason is the substantially higher efficacy of CDO therapy.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n CDO is highly efficacious in clinical practice and cost-effective compared with NPWT and other therapies such as moist wound therapy and hyperbaric oxygen.<\/jats:p>\n <\/jats:sec>","DOI":"10.36469\/001c.155760","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:28:27Z","timestamp":1770755307000},"update-policy":"https:\/\/doi.org\/10.36469\/00001","source":"Crossref","is-referenced-by-count":0,"title":["Cost-Effectiveness of Continuously Diffused Oxygen Therapy Compared with Negative-Pressure Wound Therapy"],"prefix":"10.36469","volume":"13","author":[{"given":"Matthew","family":"Mercurio","sequence":"first","affiliation":[{"name":"MGM Applied Economic Consulting, Rohnert Park, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-9952","authenticated-orcid":false,"given":"Lawrence A.","family":"Lavery","sequence":"additional","affiliation":[{"name":"UT Health San Antonio, San Antonio, Texas","department":["Orthopedics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3287-3052","authenticated-orcid":false,"given":"Animesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"UT Health San Antonio, San Antonio, Texas","department":["Orthopedics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9192-541X","authenticated-orcid":false,"given":"Alisha","family":"Oropallo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02bxt4m23","id-type":"ROR","asserted-by":"publisher"}],"name":"Donald and Barbara Zucker School of Medicine, Hofstra\/Northwell Health, Hempstead, New York","department":["Vascular Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22273","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"issue":"suppl 1","key":"ref1","doi-asserted-by":"publisher","first-page":"S203","DOI":"10.2337\/dc23-S012","article-title":"Retinopathy, neuropathy, and foot care: standards of care in diabetes\u20142023","volume":"46","author":"N. 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Chan","year":"2020","journal-title":"Int Wound J"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.51731\/cjht.2024.978","article-title":"Continuous diffused oxygen therapy for wound healing","volume":"4","year":"2024","journal-title":"Can J Health Technol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e14960","DOI":"10.1111\/iwj.14960","article-title":"The efficacy of topical oxygen therapy for wound healing: a meta-analysis of randomized controlled trials and observational studies","volume":"21","author":"I. L. Putri","year":"2024","journal-title":"Int Wound J"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1089\/wound.2022.0041","article-title":"Efficacy of topical wound oxygen therapy in healing chronic diabetic foot ulcers: systematic review and meta-analysis","volume":"12","author":"M. J. 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Chen","year":"2024","journal-title":"Diabetes Metab Res Rev"}],"container-title":["Journal of Health Economics and Outcomes Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jheor.org\/article\/155760-cost-effectiveness-of-continuously-diffused-oxygen-therapy-compared-with-negative-pressure-wound-therapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:35:45Z","timestamp":1779885345000},"score":1,"resource":{"primary":{"URL":"https:\/\/jheor.org\/article\/155760-cost-effectiveness-of-continuously-diffused-oxygen-therapy-compared-with-negative-pressure-wound-therapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,10]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.36469\/001c.155760","relation":{},"ISSN":["2327-2236"],"issn-type":[{"value":"2327-2236","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,10]]}}}