{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:27:45Z","timestamp":1793881665647,"version":"4.7.0"},"reference-count":0,"publisher":"HCA Healthcare","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HCA Healthcare Journal of Medicine"],"abstract":"<jats:p>Introduction \nThymomas are a rare form of slow-growing malignancy that originate from thymic epithelial cells presenting as an anterior mediastinal mass. Although most are asymptomatic, they can have a variety of presentations, such as local thoracic symptoms, superior vena cava syndrome, or paraneoplastic syndromes. Local compressive thoracic symptoms include shortness of breath, chest pain, and cough. Superior vena cava syndrome presents with respiratory, vascular, or neurologic symptoms. Paraneoplastic syndromes, such as myasthenia gravis, are due to abnormal T-cell maturation leading to an increased risk of autoimmune conditions.\nCase Presentation \nWe report a case of a 71-year-old White male with multiple comorbidities presenting to the emergency room after a mechanical fall with an incidental finding of a 3.8 cm x 6.0 cm anterior mediastinal mass. The patient had no local compressive symptoms or paraneoplastic syndromes. Due to the coronavirus disease 2019 (COVID-19) pandemic, the patient did not follow through with the discharge recommendations for surgical consultation. Over a year later, the patient presented to the emergency room for congestive heart failure exacerbation, and chest computed tomography revealed the mass had increased in size to 8.2 cm x 7.7 cm. A multidisciplinary approach was used to determine the patient\u2019s course of treatment. Due to the patient\u2019s debilitated state and concern for local invasion, radical thymectomy with mediastinal lymph node dissection was planned. Despite medical optimization and coordination with a multidisciplinary team, following surgery, the patient became symptomatically bradycardic with acute hypoxic respiratory failure. The patient ultimately passed away after pulseless electrical activity and the family\u2019s decision to discontinue resuscitation.\nConclusion \nIt is imperative to consider the negative impacts of the COVID-19 pandemic. Delay in treatment allowed the thymoma to rapidly grow, thus leading to a decreased chance for cure. An extensive surgery increased perioperative risks that led to unforeseen complications resulting in the untimely death of the patient.<\/jats:p>","DOI":"10.36518\/2689-0216.1458","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T13:21:02Z","timestamp":1698844862000},"source":"Crossref","is-referenced-by-count":0,"title":["Implications of COVID-19 On A Rapidly Growing Thymoma Case"],"prefix":"10.36518","volume":"4","author":[{"given":"Neeraja","family":"Narayanan","sequence":"first","affiliation":[{"name":"UNTHSC Texas College of Osteopathic Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaleh","family":"Motamedi","sequence":"additional","affiliation":[{"name":"UNTHSC Texas College of Osteopathic Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lalonde","sequence":"additional","affiliation":[{"name":"Medical City Arlington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Tauriainen","sequence":"additional","affiliation":[{"name":"Medical City Arlington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22435","published-online":{"date-parts":[[2023,10,31]]},"container-title":["HCA Healthcare Journal of Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:43:43Z","timestamp":1793879023000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.hcahealthcare.com\/hcahealthcarejournal\/vol4\/iss5\/8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,31]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,10,31]]}},"URL":"https:\/\/doi.org\/10.36518\/2689-0216.1458","relation":{},"ISSN":["2689-0216"],"issn-type":[{"value":"2689-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,31]]}}}