{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:24:06Z","timestamp":1793960646144,"version":"4.8.0"},"reference-count":0,"publisher":"HCA Healthcare","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HCA Healthcare Journal of Medicine"],"abstract":"<jats:p>Background \nCOVID-19 infection, particularly with the Delta variant, has been associated with a heightened risk of thromboembolic events due to a profound hypercoagulable state. While venous thrombosis is more commonly reported, arterial thrombosis\u2014including acute limb ischemia\u2014has emerged as a serious complication with significant morbidity and mortality.\nCase Presentation \nWe report the case of a 53-year-old man with severe COVID-19 pneumonia who developed recurrent acute limb ischemia secondary to an aortic mural thrombus. Despite therapeutic anticoagulation and multiple surgical interventions\u2014including thrombectomy, angioplasty, and stenting\u2014the patient experienced repeated episodes of arterial thrombosis. His clinical course was further complicated by pneumothorax and hemothorax, ultimately resulting in cardiopulmonary arrest and death.\nConclusion \nThis case highlights the aggressive and resistant nature of arterial thrombosis in the setting of severe COVID-19. Recurrent arterial thrombosis in severe COVID-19 underscores the need for early recognition and aggressive anticoagulation strategies. Further research is warranted to establish protocols for thromboembolic prevention in this high-risk population.<\/jats:p>","DOI":"10.36518\/2689-0216.1580","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T15:03:32Z","timestamp":1756566212000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent, Acute Limb Ischemia Secondary to Arterial Thrombosis: A Devastating Complication in the Setting of Severe COVID-19 Infection"],"prefix":"10.36518","volume":"6","author":[{"given":"Shaikh","family":"Afaq","sequence":"first","affiliation":[{"name":"HCA Florida Oak Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle S","family":"Strouse","sequence":"additional","affiliation":[{"name":"HCA Florida Oak Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sini","family":"Saju","sequence":"additional","affiliation":[{"name":"HCA Florida Oak Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olugbenga","family":"Oyesanmi","sequence":"additional","affiliation":[{"name":"HCA Healthcare Graduate Medical Education"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Eid","sequence":"additional","affiliation":[{"name":"HCA Florida Oak Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Muddassir","sequence":"additional","affiliation":[{"name":"HCA Florida Oak Hill Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22435","published-online":{"date-parts":[[2025,8,29]]},"container-title":["HCA Healthcare Journal of Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:25:18Z","timestamp":1793957118000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.hcahealthcare.com\/hcahealthcarejournal\/vol6\/iss4\/5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,8,29]]}},"URL":"https:\/\/doi.org\/10.36518\/2689-0216.1580","relation":{},"ISSN":["2689-0216"],"issn-type":[{"value":"2689-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}