{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:24:16Z","timestamp":1793960656445,"version":"4.8.0"},"reference-count":0,"publisher":"HCA Healthcare","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HCA Healthcare Journal of Medicine"],"abstract":"<jats:p>Background \nParkinson\u2019s disease is a primary neurological dysfunction syndrome in which the body\u2019s natural production of dopamine is reduced. Therapeutic intervention for this disease primarily includes medications that increase the body\u2019s natural production of dopamine. These medications can have side effects, requiring constant titration based on the patient\u2019s symptoms.\nCase Presentation \nWe report a case study of a 75-year-old man diagnosed with Parkinson\u2019s disease who had a profound acute exacerbation of psychological symptoms following modifications to his dopaminergic treatment regimen. Initially, the patient was prescribed carbidopa\/levodopa, rasagiline, and carbidopa\/levodopa\/entacapone. However, the treatment plan was adjusted due to the worsening of symptoms. The dose of carbidopa\/levodopa was reduced, and rasagiline and Stalevo were stopped. Although the patient initially saw a temporary improvement, the patient later had hallucinations, delusions, agitation, dyskinesias, and akathisia. The laboratory testing and CT scan results showed no significant abnormalities.\nConclusion \nThis case highlights the importance of accurate dosage and vigilant supervision of Parkinson\u2019s disease medications\u2019 \u201cwearing off\u201d phenomenon. The patient\u2019s varying reaction to changes in medication and the subsequent appearance of psychiatric symptoms highlights the need for an individualized approach to managing Parkinson\u2019s disease. Collectively, these symptoms suggest that clinicians should consider the possibility of non-linear connections between dopaminergic therapy and symptom control. To effectively address the intricate relationship between motor symptoms and psychiatric manifestations, it is imperative to implement a multidisciplinary team approach in future management. This approach would involve closely monitoring and adapting treatment strategies.<\/jats:p>","DOI":"10.36518\/2689-0216.1718","type":"journal-article","created":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T06:26:56Z","timestamp":1740896816000},"source":"Crossref","is-referenced-by-count":2,"title":["The \u201cWearing Off\u201d Phenomenon for Rasagiline, Entacapone, Carbidopa, and Levodopa in the Setting of Parkinson\u2019s Disease"],"prefix":"10.36518","volume":"6","author":[{"given":"Ryan","family":"Cromwell","sequence":"first","affiliation":[{"name":"HCA Florida Citrus Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevin","family":"Um","sequence":"additional","affiliation":[{"name":"HCA Florida Citrus Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22435","published-online":{"date-parts":[[2025,2,28]]},"container-title":["HCA Healthcare Journal of Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:26:17Z","timestamp":1793957177000},"score":1,"resource":{"primary":{"URL":"https:\/\/scholarlycommons.hcahealthcare.com\/hcahealthcarejournal\/vol6\/iss1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2,28]]}},"URL":"https:\/\/doi.org\/10.36518\/2689-0216.1718","relation":{},"ISSN":["2689-0216"],"issn-type":[{"value":"2689-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]}}}