{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:45:11Z","timestamp":1790725511132,"version":"4.1.0"},"reference-count":0,"publisher":"Doc Design and Informatics Co. Ltd.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect Dis Clin Microbiol"],"abstract":"<jats:p>Objective: Fournier\u2019s gangrene (FG) is a rare necrotizing fasciitis affecting genital and perianal areas. This study aimed to provide data on predicting factors, mortality rates, and factors affecting mortality in comparison of survivors and non-survivors in patients with FG. \n\nMaterials and Methods: This study included a retrospective analysis of patients diagnosed with FG between 2008 and 2018. \n\nResults: A total of 97 patients with FG were included in this study. Of the patients, 72 (74%) were male. The mean age was 56.03\u00b113.92 years, and the median was 57 (21-90). The mortality rate was 21.6%. The most frequently isolated microorganism from tissue and blood cultures was Escherichia coli (43%-42%). The median Fournier\u2019s Gangrene Severity Index (FGSI) and Uluda\u011f FGSI (UFGSI) scores were 4 (0-20) and 5 (1-22), respectively. In the univariate model, mortality risk increases 7.18 times (p=0.001) in patients with two or more comorbidities, 1.31 times as the FGSI score increases (p&lt;0.001), 1.28 times as the UFGSI score increases (p&lt;0.001). When the cut-off value was set as 8 for the FGSI score, the sensitivity was 71.43%, and the specificity was 73.68%. The sensitivity was 73.43%, and the specificity was 75% when the cut-off value was set as 6 for the UFGSI score. In the univariate model, the mortality risk of those with hypotension was 6.07 times higher (p=0.003); as the platelet count increased, mortality risk decreased (odds ratio [OR]=0.99; p=0.02). The mortality risk of those hospitalized in the intensive care unit (ICU) was 16.5 times higher than those followed in the ward (p&lt;0.001). In the multivariate model, this ratio was 6.49. \n\nConclusion: We concluded that FGSI and UFGSI scores could be used to predict mortality. Management of FG requires a multidisciplinary approach. Empiric treatment should include carbapenems and be de-escalated once getting the culture results. Authors from different centers should report their experiences to help reveal the ideal treatment and evaluate the consequences. \n\nKeywords: Fournier\u2019s gangrene, necrotizing fasciitis, severity index, FGSI, UFGSI<\/jats:p>","DOI":"10.36519\/idcm.2023.177","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T15:31:57Z","timestamp":1678807917000},"page":"13-22","source":"Crossref","is-referenced-by-count":11,"title":["Fournier\u2019s Gangrene: Microbiological Profile and Risk Factors for Mortality: Review of 97 Cases"],"prefix":"10.36519","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-1991","authenticated-orcid":false,"given":"Aynur","family":"Atilla","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Ondokuz May\u0131s University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-8242","authenticated-orcid":false,"given":"Fatih","family":"Temocin","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Ondokuz May\u0131s University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-367X","authenticated-orcid":false,"given":"Tuba","family":"Kuruoglu","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Ondokuz May\u0131s University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-9435","authenticated-orcid":false,"given":"Ayfer","family":"Kamali-Polat","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Ondokuz May\u0131s University School of Medicine, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22401","published-online":{"date-parts":[[2023,3,11]]},"container-title":["Infectious Diseases and Clinical Microbiology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T15:31:59Z","timestamp":1678807919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.idcmjournal.org\/fourniers-gangrene-review-of-97-cases"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,11]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,3,11]]}},"URL":"https:\/\/doi.org\/10.36519\/idcm.2023.177","archive":["Internet Archive"],"relation":{},"ISSN":["2667-646X"],"issn-type":[{"value":"2667-646X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,11]]}}}