{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:33:51Z","timestamp":1772253231669,"version":"3.50.1"},"reference-count":0,"publisher":"Doc Design and Informatics Co. Ltd.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect Dis Clin Microbiol"],"abstract":"<jats:p>Objective: This study aimed to define the predictors of critical illness development within 28 days postadmission during the first wave of the COVID-19 pandemic. \n\nMaterials and Methods: We conducted a prospective cohort study including 477 PCR-positive COVID-19 patients admitted to a tertiary care hospital in Istanbul from March 12 to May 12, 2020. \n\nResults: The most common presenting symptoms were cough, dyspnea, and fatigue. Critical illness developed in 45 (9.4%; 95% CI=7.0%-12.4%) patients. In the multivariable analysis, age (hazard ratio (HR)=1.05, p&lt;0.001), number of comorbidities (HR=1.33, p=0.02), procalcitonin \u22650.25 \u00b5g\/L (HR=2.12, p=0.03) and lactate dehydrogenase (LDH) \u2265350 U\/L (HR=2.04, p=0.03) were independently associated with critical illness development. The World Health Organization (WHO) ordinal scale for clinical improvement on admission was the strongest predictor of critical illness (HR=4.15, p&lt;0.001). The patients hospitalized at the end of the study period had a much better prognosis compared to the patients hospitalized at the beginning (HR=0.14; p=0.02). The C-index of the model was 0.92. \n\nConclusion: Age, comorbidity number, the WHO scale, LDH, and procalcitonin were independently associated with critical illness development. Mortality from COVID-19 seemed to be decreasing as the first wave of the pandemic advanced.\n\nKeywords: COVID-19, prospective cohort, critical illness, prognosis<\/jats:p>","DOI":"10.36519\/idcm.2023.206","type":"journal-article","created":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T12:22:31Z","timestamp":1688300551000},"page":"94-105","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated with 28-day Critical Illness Development During the First Wave of COVID-19"],"prefix":"10.36519","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-9298","authenticated-orcid":false,"given":"Uluhan","family":"Sili","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-1343","authenticated-orcid":false,"given":"Pinar","family":"Ay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-548X","authenticated-orcid":false,"given":"Ahmet","family":"Topuzoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5048-9970","authenticated-orcid":false,"given":"Huseyin","family":"Bilgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2027-4116","authenticated-orcid":false,"given":"Elif","family":"Tukenmez-Tigen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2182-4693","authenticated-orcid":false,"given":"Buket","family":"Ert\u00fcrk-Sengel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3473-8073","authenticated-orcid":false,"given":"Dilek","family":"Yagc\u0131-\u00c7aglayik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1804-1970","authenticated-orcid":false,"given":"Baran","family":"Balcan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-6813","authenticated-orcid":false,"given":"Derya","family":"Kocakaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3236-3995","authenticated-orcid":false,"given":"Sehnaz","family":"Olgun-Yildizeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6426-6436","authenticated-orcid":false,"given":"Fethi","family":"Gul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3466-0771","authenticated-orcid":false,"given":"Beliz","family":"Bilgili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-8659","authenticated-orcid":false,"given":"Rabia","family":"Can-Sarinoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1560-2624","authenticated-orcid":false,"given":"Aysegul","family":"Karahasan-Yagci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-473X","authenticated-orcid":false,"given":"Lutfiye","family":"Mulazimoglu-Durmusoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2194-8066","authenticated-orcid":false,"given":"Emel","family":"Eryuksel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-6999","authenticated-orcid":false,"given":"Zekaver","family":"Odabasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2598-5806","authenticated-orcid":false,"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-5798","authenticated-orcid":false,"given":"Sait","family":"Karakurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7595-1295","authenticated-orcid":false,"given":"Ismail","family":"Cinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9991-814X","authenticated-orcid":false,"given":"Volkan","family":"Korten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"22401","published-online":{"date-parts":[[2023,6,23]]},"container-title":["Infectious Diseases and Clinical Microbiology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T12:22:34Z","timestamp":1688300554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.idcmjournal.org\/critical-illness-development-in-covid-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,6,23]]}},"URL":"https:\/\/doi.org\/10.36519\/idcm.2023.206","archive":["Internet Archive","Internet Archive"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.10.09.20209775","asserted-by":"object"}]},"ISSN":["2667-646X"],"issn-type":[{"value":"2667-646X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]}}}