{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:59:08Z","timestamp":1790956748739,"version":"4.1.0"},"reference-count":0,"publisher":"Doc Design and Informatics Co. Ltd.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Objective: Although HIV RNA can be suppressed with antiretroviral therapy (ART), chronic inflammation may persist in people living with HIV (PLWH). Because a low CD4+\/CD8+ ratio is associated with morbidity and mortality, this study aimed to evaluate factors associated with CD4+\/CD8+ ratio normalization, defined as a CD4+\/CD8+ ratio \u22651.\n\nMaterials and Methods: This retrospective cohort study included PLWH aged \u226518 years who were diagnosed between 2010 and 2017 and achieved viral suppression within the first year after starting ART. Data were retrospectively obtained from a tertiary care infectious diseases clinic.\n\nResults: Among 217 patients who received ART for at least 5 years, 187 (86.2%) had a CD4+ T-cell count &gt;500 cells\/\u03bcL at year 5, and 87 (40.1%) achieved a CD4+\/CD8+ ratio \u22651. In multivariable logistic regression, higher baseline CD4+ T-cell count and a higher baseline CD4+\/CD8+ ratio were independently associated with CD4+\/CD8+ ratio normalization.\n\nConclusion: Including immunological markers alongside viral suppression may better reflect treatment success. Baseline immunological status appears to be associated with long-term CD4+\/CD8+ ratio normalization in PLWH receiving suppressive ART. Monitoring these markers may help inform long-term follow-up strategies.<\/jats:p>","DOI":"10.36519\/idcm.2026.1061","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:46:22Z","timestamp":1790955982000},"page":"461","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated with CD4\u207a\/CD8\u207a Ratio Normalization in People Living with HIV During Long-Term ART"],"prefix":"10.36519","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-1309","authenticated-orcid":false,"given":"Gamze","family":"Konyal\u0131","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-0168","authenticated-orcid":false,"given":"Fatma Merve","family":"Ko\u00e7ak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-3343","authenticated-orcid":false,"given":"Ayse","family":"\u0130nci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22401","published-online":{"date-parts":[[2026,9,30]]},"container-title":["Infectious Diseases and Clinical Microbiology"],"original-title":[],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:46:22Z","timestamp":1790955982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.idcmjournal.org\/cd4-cd8-ratio-normalization-in-plwh"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.36519\/idcm.2026.1061","relation":{},"ISSN":["2667-646X"],"issn-type":[{"value":"2667-646X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"article-number":"1061"}}