{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:23:52Z","timestamp":1791559432832,"version":"4.3.4"},"reference-count":0,"publisher":"Doc Design and Informatics Co. Ltd.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Immune checkpoint inhibitor therapy has transformed the prognosis of multiple solid-organ malignancies; however, such advances are not without significant adverse events known as immune-related adverse events. A novel pattern of autoimmune-like hepatitis following exposure to certain medications, including statins, isoniazid, nitrofurantoin, anti-tumor necrosis factor-alpha therapy and minocycline, has recently been recognized. We present the case of a 66-year-old male patient with extensive-stage small-cell lung carcinoma who developed acute liver injury while receiving concomitant atezolizumab therapy and isoniazid prophylaxis for latent tuberculosis. The patient subsequently developed grade 4 hepatotoxicity, which improved after discontinuation of isoniazid therapy and initiation of corticosteroid treatment. The aim of this report is to contribute to the literature by presenting a rare case of grade 4 immune-related hepatotoxicity under atezolizumab therapy in a patient receiving isoniazid prophylaxis for latent tuberculosis.<\/jats:p>","DOI":"10.36519\/idcm.2026.926","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:30:11Z","timestamp":1785331811000},"page":"413","source":"Crossref","is-referenced-by-count":1,"title":["Immune-Related Hepatotoxicity After Atezolizumab and Isoniazid"],"prefix":"10.36519","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4860-0594","authenticated-orcid":false,"given":"Enes","family":"Karakaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7676-9675","authenticated-orcid":false,"given":"Erdem","family":"\u00c7\u0131\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2043-2041","authenticated-orcid":false,"given":"Burcu","family":"Saka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9840-7703","authenticated-orcid":false,"given":"Hilal","family":"Ka\u011f\u0131zmanl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-2746","authenticated-orcid":false,"given":"Sidar","family":"\u00c7\u00f6p\u00fcr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5856-5384","authenticated-orcid":false,"given":"Genco","family":"Gen\u00e7dal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"22401","published-online":{"date-parts":[[2026,7,28]]},"container-title":["Infectious Diseases and Clinical Microbiology"],"original-title":[],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:30:11Z","timestamp":1785331811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.idcmjournal.org\/atezolizumab-related-hepatotoxicity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.36519\/idcm.2026.926","relation":{},"ISSN":["2667-646X"],"issn-type":[{"value":"2667-646X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"article-number":"926"}}