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Br J Clin Pharmacol. 2017;83(10):2274-82.","journal-title":"Br J Clin Pharmacol"},{"issue":"2","key":"key20201218142432_B48","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1124\/jpet.102.038240","article-title":"Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents","volume":"303","author":"Katchman","year":"2002","unstructured":". Katchman AN, McGroary KA, Kilborn MJ, Kornick CA, Manfredi PL, Woosley RL,  et al. Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents. J Pharmacol Exp Ther. 2002; 303(2):688\u201394.","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"key20201218142432_B49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4103\/0976-3147.91934","article-title":"Buprenorphine vs methadone treatment: A review of evidence in both developed and developingworlds","volume":"3","author":"Whelan","year":"2012","unstructured":". Whelan PJ, Remski K. Buprenorphine vs methadone treatment: A review of evidence in both developed and developingworlds. J Neurosci Rural Pract. 2012 Jan;3(1):45-50.","journal-title":"J Neurosci Rural Pract"},{"issue":"10","key":"key20201218142432_B50","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1111\/bcp.13326","article-title":"QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings","volume":"83","author":"Isbister","year":"2017","unstructured":". Isbister GK, Brown AL, Gill A, Scott AJ, Calver L, Dunlop AJ. QT interval prolongation in opioid agonist treatment: analysis of continuous 12-lead electrocardiogram recordings. Br J Clin Pharmacol. 2017;83(10):2274-82.","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"key20201218142432_B51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/00325481.2017.1270156","article-title":"Effects of buprenorphine on QT intervals in healthy subjects: results of 2 randomized positive- and placebo-controlled trials","volume":"129","author":"Harris","year":"2017","unstructured":". Harris SC, Morganroth J, Ripa SR, Thorn MD, Colucci S. Effects of buprenorphine on QT intervals in healthy subjects: results of 2 randomized positive- and placebo-controlled trials. Postgrad Med. 2017;129(1):69-80.","journal-title":"Postgrad Med"},{"key":"key20201218142432_B52","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.drugalcdep.2012.09.016","article-title":"Corrected QT interval during treatment with methadone and buprenorphine--relation to doses and serum concentrations","volume":"129","author":"Stallvik","year":"2013","unstructured":". Stallvik M, Nordstrand B, Kristensen \u00d8, Bathen J, Skogvoll E, Spigset O. Corrected QT interval during treatment with methadone and buprenorphine--relation to doses and serum concentrations. Drug Alcohol Depend. 2013;129(1-2):88-93.","journal-title":"Drug Alcohol Depend"},{"key":"key20201218142432_B53","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.drugalcdep.2016.12.001","article-title":"The Prescription Opioid Addiction Treatment Study: What have we learned","volume":"173","author":"Weiss","year":"2017","unstructured":". Weiss RD, Rao V. The Prescription Opioid Addiction Treatment Study: What have we learned. Drug Alcohol Depend. 2017 Apr 1;173 Suppl 1:S48-S54.","journal-title":"Drug Alcohol Depend"},{"issue":"1","key":"key20201218142432_B54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1742-7843.2006.pto_233.x","article-title":"Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients","volume":"98","author":"Rook","year":"2006","unstructured":". Rook, E.J, van Ree, J.M, van den Brink, W, Hillebrand, M.J, Huitema, A.D, Hendriks, V.M, et al. Pharmacokinetics and pharmacodynamics of high doses of pharmaceutically prepared heroin, by intravenous or by inhalation route in opioid-dependent patients. Basic Clin Pharmacol Toxicol. 2006;98(1):86\u201396.","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"7","key":"key20201218142432_B55","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/jat\/24.7.522","article-title":"Detection times and analytical performance of commercial urine opiate immunoassays following heroin administration","volume":"24","author":"Smith","year":"2000","unstructured":". Smith, M.L., Shimomura, E.T., Summers, J., Paul, B.D., Nichols, D., Shippee, R., et al. Detection times and analytical performance of commercial urine opiate immunoassays following heroin administration. J Analyt Toxicol. 2000; 24(7):522\u20139.","journal-title":"J Analyt Toxicol"},{"issue":"12","key":"key20201218142432_B56","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1007\/s11606-012-2089-2","article-title":"Cardiac complications of unwitting co-injection of quinine\/quinidine with heroin in an intravenous drug user","volume":"27","author":"Phillips","year":"2012","unstructured":". Phillips KA, Hirsch GA, Epstein DH, Preston KL. Cardiac complications of unwitting co-injection of quinine\/quinidine with heroin in an intravenous drug user. 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